The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 14: Retinoic acid receptor responder 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 Q99969 (/IPI) Q99969 (/IPI) Q99969 (/IPI) Q9DD06 (/IPI)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
3 Q99969 (/IPI) Q99969 (/IPI) Q99969 (/IPI)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q9DD06 (/ISO)

There are 31 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of fat cell differentiation GO:0045600
Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
8 Q29RS5 (/ISS) Q29RS5 (/ISS) Q5R551 (/ISS) Q5R551 (/ISS) Q8HDG8 (/ISS) Q99969 (/ISS) Q99969 (/ISS) Q99969 (/ISS)
Positive regulation of chemotaxis GO:0050921
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
8 Q29RS5 (/ISS) Q29RS5 (/ISS) Q5R551 (/ISS) Q5R551 (/ISS) Q8HDG8 (/ISS) Q99969 (/ISS) Q99969 (/ISS) Q99969 (/ISS)
Regulation of lipid catabolic process GO:0050994
Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids.
8 Q29RS5 (/ISS) Q29RS5 (/ISS) Q5R551 (/ISS) Q5R551 (/ISS) Q8HDG8 (/ISS) Q99969 (/ISS) Q99969 (/ISS) Q99969 (/ISS)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
5 Q29RS5 (/ISS) Q29RS5 (/ISS) Q5R551 (/ISS) Q5R551 (/ISS) Q8HDG8 (/ISS)
Regulation of insulin receptor signaling pathway GO:0046626
Any process that modulates the frequency, rate or extent of insulin receptor signaling.
5 Q29RS5 (/ISS) Q29RS5 (/ISS) Q5R551 (/ISS) Q5R551 (/ISS) Q8HDG8 (/ISS)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
4 Q99969 (/IDA) Q99969 (/IDA) Q99969 (/IDA) Q9DD06 (/IDA)
Retinoid metabolic process GO:0001523
The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
3 Q99969 (/IDA) Q99969 (/IDA) Q99969 (/IDA)
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
3 Q99969 (/TAS) Q99969 (/TAS) Q99969 (/TAS)
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
3 Q99969 (/IDA) Q99969 (/IDA) Q99969 (/IDA)
Positive regulation of macrophage chemotaxis GO:0010759
Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.
3 Q99969 (/IMP) Q99969 (/IMP) Q99969 (/IMP)
Antifungal humoral response GO:0019732
An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster.
3 Q99969 (/IMP) Q99969 (/IMP) Q99969 (/IMP)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
3 Q99969 (/IMP) Q99969 (/IMP) Q99969 (/IMP)
Embryonic digestive tract development GO:0048566
The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus.
3 Q99969 (/IMP) Q99969 (/IMP) Q99969 (/IMP)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
3 Q99969 (/IMP) Q99969 (/IMP) Q99969 (/IMP)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
3 Q99969 (/IMP) Q99969 (/IMP) Q99969 (/IMP)
Antifungal innate immune response GO:0061760
An defense response against a fungus mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens.
3 Q99969 (/IMP) Q99969 (/IMP) Q99969 (/IMP)
Retinoid metabolic process GO:0001523
The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
1 Q9DD06 (/ISO)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 Q9DD06 (/ISO)
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
1 Q9DD06 (/ISO)
Positive regulation of macrophage chemotaxis GO:0010759
Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.
1 Q9DD06 (/ISO)
Antifungal humoral response GO:0019732
An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster.
1 Q9DD06 (/ISO)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
1 Q9DD06 (/ISO)
Positive regulation of fat cell differentiation GO:0045600
Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
1 Q9DD06 (/IMP)
Regulation of insulin receptor signaling pathway GO:0046626
Any process that modulates the frequency, rate or extent of insulin receptor signaling.
1 Q9DD06 (/IDA)
Embryonic digestive tract development GO:0048566
The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus.
1 Q9DD06 (/ISO)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
1 Q9DD06 (/ISO)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
1 Q9DD06 (/ISO)
Brown fat cell differentiation GO:0050873
The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
1 Q9DD06 (/IDA)
Positive regulation of chemotaxis GO:0050921
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
1 Q9DD06 (/IDA)
Regulation of lipid catabolic process GO:0050994
Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids.
1 Q9DD06 (/IMP)
Antifungal innate immune response GO:0061760
An defense response against a fungus mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens.
1 Q9DD06 (/ISO)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
8 Q29RS5 (/ISS) Q29RS5 (/ISS) Q5R551 (/ISS) Q5R551 (/ISS) Q8HDG8 (/ISS) Q99969 (/ISS) Q99969 (/ISS) Q99969 (/ISS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 Q99969 (/TAS) Q99969 (/TAS) Q99969 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 Q99969 (/IDA) Q99969 (/IDA) Q99969 (/IDA)
Platelet dense granule lumen GO:0031089
The volume enclosed by the membrane of the platelet dense granule.
3 Q99969 (/TAS) Q99969 (/TAS) Q99969 (/TAS)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
3 Q99969 (/IDA) Q99969 (/IDA) Q99969 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q9DD06 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q9DD06 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q9DD06 (/ISO)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
1 Q9DD06 (/ISO)