The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 77: gamma-aminobutyric acid receptor-associated protei...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
110 P60520 (/IPI) P60520 (/IPI) P60520 (/IPI) P60520 (/IPI) P60520 (/IPI) P60520 (/IPI) P60520 (/IPI) P60520 (/IPI) P60520 (/IPI) P60520 (/IPI)
(100 more)
SNARE binding GO:0000149
Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
55 P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA)
(45 more)
SNARE binding GO:0000149
Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
55 P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS)
(45 more)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
55 P60520 (/NAS) P60520 (/NAS) P60520 (/NAS) P60520 (/NAS) P60520 (/NAS) P60520 (/NAS) P60520 (/NAS) P60520 (/NAS) P60520 (/NAS) P60520 (/NAS)
(45 more)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
55 P60520 (/IPI) P60520 (/IPI) P60520 (/IPI) P60520 (/IPI) P60520 (/IPI) P60520 (/IPI) P60520 (/IPI) P60520 (/IPI) P60520 (/IPI) P60520 (/IPI)
(45 more)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
55 P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO)
(45 more)
Beta-tubulin binding GO:0048487
Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.
55 P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS)
(45 more)
GABA receptor binding GO:0050811
Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor.
55 P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS)
(45 more)
GABA receptor binding GO:0050811
Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor.
55 P60520 (/NAS) P60520 (/NAS) P60520 (/NAS) P60520 (/NAS) P60520 (/NAS) P60520 (/NAS) P60520 (/NAS) P60520 (/NAS) P60520 (/NAS) P60520 (/NAS)
(45 more)
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
55 P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA)
(45 more)
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
55 P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS)
(45 more)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Intra-Golgi vesicle-mediated transport GO:0006891
The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network).
55 P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA)
(45 more)
Intra-Golgi vesicle-mediated transport GO:0006891
The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network).
55 P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO)
(45 more)
Intra-Golgi vesicle-mediated transport GO:0006891
The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network).
55 P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS)
(45 more)
Intra-Golgi vesicle-mediated transport GO:0006891
The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network).
55 P60519 (/NAS) P60519 (/NAS) P60519 (/NAS) P60519 (/NAS) P60519 (/NAS) P60519 (/NAS) P60519 (/NAS) P60519 (/NAS) P60519 (/NAS) P60519 (/NAS)
(45 more)
Autophagy GO:0006914
The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
55 P60520 (/NAS) P60520 (/NAS) P60520 (/NAS) P60520 (/NAS) P60520 (/NAS) P60520 (/NAS) P60520 (/NAS) P60520 (/NAS) P60520 (/NAS) P60520 (/NAS)
(45 more)
Macroautophagy GO:0016236
The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded.
55 P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS)
(45 more)
Positive regulation of ATPase activity GO:0032781
Any process that activates or increases the rate of ATP hydrolysis by an ATPase.
55 P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA)
(45 more)
Positive regulation of ATPase activity GO:0032781
Any process that activates or increases the rate of ATP hydrolysis by an ATPase.
55 P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS)
(45 more)
Autophagosome maturation GO:0097352
Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling.
55 P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS)
(45 more)
Negative regulation of proteasomal protein catabolic process GO:1901799
Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process.
55 P60520 (/IMP) P60520 (/IMP) P60520 (/IMP) P60520 (/IMP) P60520 (/IMP) P60520 (/IMP) P60520 (/IMP) P60520 (/IMP) P60520 (/IMP) P60520 (/IMP)
(45 more)
Negative regulation of proteasomal protein catabolic process GO:1901799
Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process.
55 P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO)
(45 more)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
165 P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA)
(155 more)
Autophagosome GO:0005776
A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.
165 P60519 (/ISS) P60519 (/ISS) P60519 (/ISS) P60519 (/ISS) P60519 (/ISS) P60519 (/ISS) P60519 (/ISS) P60519 (/ISS) P60519 (/ISS) P60519 (/ISS)
(155 more)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
55 P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO)
(45 more)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
55 P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS)
(45 more)
Autophagosome membrane GO:0000421
The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.
55 P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA)
(45 more)
Autophagosome membrane GO:0000421
The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.
55 P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO)
(45 more)
Autophagosome membrane GO:0000421
The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.
55 P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS)
(45 more)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
55 P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA)
(45 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
55 P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA)
(45 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
55 P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO)
(45 more)
Autophagosome GO:0005776
A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.
55 P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA) P60520 (/IDA)
(45 more)
Autophagosome GO:0005776
A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.
55 P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO) P60521 (/ISO)
(45 more)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
55 P60521 (/IDA) P60521 (/IDA) P60521 (/IDA) P60521 (/IDA) P60521 (/IDA) P60521 (/IDA) P60521 (/IDA) P60521 (/IDA) P60521 (/IDA) P60521 (/IDA)
(45 more)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
55 P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS)
(45 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
55 P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA) P60519 (/IDA)
(45 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
55 P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS) P60520 (/ISS)
(45 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
55 P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS) P60520 (/TAS)
(45 more)
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