CATH Superfamily 3.10.20.90
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
".
FunFam 67: E3 ubiquitin-protein ligase RING2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
25 |
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
(15 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
25 |
Q99496 (/IPI)
Q99496 (/IPI)
Q99496 (/IPI)
Q99496 (/IPI)
Q99496 (/IPI)
Q99496 (/IPI)
Q99496 (/IPI)
Q99496 (/IPI)
Q99496 (/IPI)
Q99496 (/IPI)
(15 more) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
16 |
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
(6 more) |
|
RING-like zinc finger domain binding GO:0071535
Interacting selectively and non-covalently with a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain.
|
16 |
Q99496 (/IPI)
Q99496 (/IPI)
Q99496 (/IPI)
Q99496 (/IPI)
Q99496 (/IPI)
Q99496 (/IPI)
Q99496 (/IPI)
Q99496 (/IPI)
Q99496 (/IPI)
Q99496 (/IPI)
(6 more) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
12 |
Q4KLY4 (/ISS)
Q4KLY4 (/ISS)
Q5R9J5 (/ISS)
Q9CQJ4 (/ISS)
Q9CQJ4 (/ISS)
Q9CQJ4 (/ISS)
Q9CQJ4 (/ISS)
Q9CQJ4 (/ISS)
Q9CQJ4 (/ISS)
Q9CQJ4 (/ISS)
(2 more) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
9 | Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
9 | Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
9 | Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) |
|
RING-like zinc finger domain binding GO:0071535
Interacting selectively and non-covalently with a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain.
|
9 | Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) |
There are 22 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
21 |
Q4KLY4 (/ISS)
Q4KLY4 (/ISS)
Q5R9J5 (/ISS)
Q803I4 (/ISS)
Q803I4 (/ISS)
Q99496 (/ISS)
Q99496 (/ISS)
Q99496 (/ISS)
Q99496 (/ISS)
Q99496 (/ISS)
(11 more) |
|
Histone H2A-K119 monoubiquitination GO:0036353
The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms.
|
21 |
Q4KLY4 (/ISS)
Q4KLY4 (/ISS)
Q5R9J5 (/ISS)
Q803I4 (/ISS)
Q803I4 (/ISS)
Q99496 (/ISS)
Q99496 (/ISS)
Q99496 (/ISS)
Q99496 (/ISS)
Q99496 (/ISS)
(11 more) |
|
Histone H2A monoubiquitination GO:0035518
The modification of histone H2A by addition of a single ubiquitin group.
|
16 |
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
(6 more) |
|
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
16 |
Q99496 (/IMP)
Q99496 (/IMP)
Q99496 (/IMP)
Q99496 (/IMP)
Q99496 (/IMP)
Q99496 (/IMP)
Q99496 (/IMP)
Q99496 (/IMP)
Q99496 (/IMP)
Q99496 (/IMP)
(6 more) |
|
Negative regulation of G0 to G1 transition GO:0070317
A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase.
|
16 |
Q99496 (/TAS)
Q99496 (/TAS)
Q99496 (/TAS)
Q99496 (/TAS)
Q99496 (/TAS)
Q99496 (/TAS)
Q99496 (/TAS)
Q99496 (/TAS)
Q99496 (/TAS)
Q99496 (/TAS)
(6 more) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
9 | Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) |
|
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
|
9 | Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) |
|
Gastrulation with mouth forming second GO:0001702
A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.
|
9 | Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) |
|
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
|
9 | Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) |
|
Anterior/posterior axis specification GO:0009948
The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
|
9 | Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) |
|
Histone ubiquitination GO:0016574
The modification of histones by addition of ubiquitin groups.
|
9 | Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) |
|
Histone ubiquitination GO:0016574
The modification of histones by addition of ubiquitin groups.
|
9 | Q9CQJ4 (/IGI) Q9CQJ4 (/IGI) Q9CQJ4 (/IGI) Q9CQJ4 (/IGI) Q9CQJ4 (/IGI) Q9CQJ4 (/IGI) Q9CQJ4 (/IGI) Q9CQJ4 (/IGI) Q9CQJ4 (/IGI) |
|
Histone H2A monoubiquitination GO:0035518
The modification of histone H2A by addition of a single ubiquitin group.
|
9 | Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) |
|
Histone H2A-K119 monoubiquitination GO:0036353
The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms.
|
9 | Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) Q9CQJ4 (/IMP) |
|
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
9 | Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) |
|
Spinal cord development GO:0021510
The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues.
|
2 | Q4KLY4 (/IEP) Q4KLY4 (/IEP) |
|
Regulation of chondrocyte differentiation GO:0032330
Any process that modulates the frequency, rate or extent of chondrocyte differentiation.
|
2 | Q803I4 (/IMP) Q803I4 (/IMP) |
|
Response to retinoic acid GO:0032526
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
|
2 | Q4KLY4 (/IEP) Q4KLY4 (/IEP) |
|
Pectoral fin development GO:0033339
The process whose specific outcome is the progression of the pectoral fin over time, from its formation to the mature structure.
|
2 | Q803I4 (/IMP) Q803I4 (/IMP) |
|
Embryonic cranial skeleton morphogenesis GO:0048701
The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase.
|
2 | Q803I4 (/IMP) Q803I4 (/IMP) |
|
Retina morphogenesis in camera-type eye GO:0060042
The process in which the anatomical structure of the retina is generated and organized.
|
2 | Q803I4 (/IGI) Q803I4 (/IGI) |
|
Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902254
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator.
|
2 | Q803I4 (/IMP) Q803I4 (/IMP) |
There are 22 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ubiquitin ligase complex GO:0000151
A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
|
25 |
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
(15 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
25 |
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
(15 more) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
25 |
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
(15 more) |
|
PcG protein complex GO:0031519
A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.
|
25 |
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
(15 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
16 |
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
(6 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
16 |
Q99496 (/TAS)
Q99496 (/TAS)
Q99496 (/TAS)
Q99496 (/TAS)
Q99496 (/TAS)
Q99496 (/TAS)
Q99496 (/TAS)
Q99496 (/TAS)
Q99496 (/TAS)
Q99496 (/TAS)
(6 more) |
|
PRC1 complex GO:0035102
A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling.
|
16 |
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
(6 more) |
|
MLL1 complex GO:0071339
A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
|
16 |
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
Q99496 (/IDA)
(6 more) |
|
MLL1 complex GO:0071339
A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
|
14 |
Q4KLY4 (/ISS)
Q4KLY4 (/ISS)
Q5R9J5 (/ISS)
Q803I4 (/ISS)
Q803I4 (/ISS)
Q9CQJ4 (/ISS)
Q9CQJ4 (/ISS)
Q9CQJ4 (/ISS)
Q9CQJ4 (/ISS)
Q9CQJ4 (/ISS)
(4 more) |
|
Ubiquitin ligase complex GO:0000151
A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
|
12 |
Q4KLY4 (/ISS)
Q4KLY4 (/ISS)
Q5R9J5 (/ISS)
Q9CQJ4 (/ISS)
Q9CQJ4 (/ISS)
Q9CQJ4 (/ISS)
Q9CQJ4 (/ISS)
Q9CQJ4 (/ISS)
Q9CQJ4 (/ISS)
Q9CQJ4 (/ISS)
(2 more) |
|
Ubiquitin ligase complex GO:0000151
A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
|
9 | Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) |
|
Euchromatin GO:0000791
A dispersed and relatively uncompacted form of chromatin.
|
9 | Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) |
|
Heterochromatin GO:0000792
A compact and highly condensed form of chromatin.
|
9 | Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) |
|
Sex chromatin GO:0001739
Chromatin that is part of a sex chromosome.
|
9 | Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) Q9CQJ4 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
9 | Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
9 | Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
9 | Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) |
|
PcG protein complex GO:0031519
A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.
|
9 | Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) |
|
PRC1 complex GO:0035102
A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling.
|
9 | Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) |
|
MLL1 complex GO:0071339
A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
|
9 | Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) Q9CQJ4 (/ISO) |
|
PcG protein complex GO:0031519
A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.
|
5 | Q4KLY4 (/ISS) Q4KLY4 (/ISS) Q5R9J5 (/ISS) Q803I4 (/ISS) Q803I4 (/ISS) |
|
PRC1 complex GO:0035102
A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling.
|
5 | Q4KLY4 (/ISS) Q4KLY4 (/ISS) Q5R9J5 (/ISS) Q803I4 (/ISS) Q803I4 (/ISS) |