CATH Superfamily 3.10.20.90
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
".
FunFam 65: Cordon-bleu WH2 repeat protein
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | D3ZUI5 (/IPI) O75128 (/IPI) Q5NBX1 (/IPI) |
Actin monomer binding GO:0003785
Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
|
1 | Q5NBX1 (/IDA) |
Actin monomer binding GO:0003785
Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
|
1 | O75128 (/ISS) |
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
1 | Q53SF7 (/HDA) |
There are 28 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Embryonic axis specification GO:0000578
The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo.
|
1 | Q5NBX1 (/IEP) |
Embryonic axis specification GO:0000578
The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo.
|
1 | O75128 (/ISS) |
Somite specification GO:0001757
The process in which individual somites establish identity during embryogenesis.
|
1 | Q5NBX1 (/IEP) |
Somite specification GO:0001757
The process in which individual somites establish identity during embryogenesis.
|
1 | O75128 (/ISS) |
Neural tube closure GO:0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
|
1 | Q5NBX1 (/IGI) |
Neural tube closure GO:0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
|
1 | O75128 (/ISS) |
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
|
1 | Q5NBX1 (/IEP) |
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
|
1 | O75128 (/ISS) |
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
|
1 | E7F568 (/IMP) |
Heart jogging GO:0003146
The morphogenetic process in which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis.
|
1 | E7F568 (/IMP) |
Actin filament polymerization GO:0030041
Assembly of actin filaments by the addition of actin monomers to a filament.
|
1 | Q5NBX1 (/IMP) |
Actin filament polymerization GO:0030041
Assembly of actin filaments by the addition of actin monomers to a filament.
|
1 | O75128 (/ISS) |
Notochord development GO:0030903
The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.
|
1 | Q5NBX1 (/IEP) |
Notochord development GO:0030903
The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.
|
1 | O75128 (/ISS) |
Floor plate development GO:0033504
The progression of the floor plate over time from its initial formation until its mature state.
|
1 | Q5NBX1 (/IEP) |
Floor plate development GO:0033504
The progression of the floor plate over time from its initial formation until its mature state.
|
1 | O75128 (/ISS) |
Digestive tract development GO:0048565
The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.
|
1 | Q5NBX1 (/IEP) |
Digestive tract development GO:0048565
The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.
|
1 | O75128 (/ISS) |
Collateral sprouting in absence of injury GO:0048669
The process in which outgrowths develop from the axons of intact undamaged neurons.
|
1 | Q5NBX1 (/IMP) |
Collateral sprouting in absence of injury GO:0048669
The process in which outgrowths develop from the axons of intact undamaged neurons.
|
1 | O75128 (/ISS) |
Actin filament network formation GO:0051639
The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments.
|
1 | Q5NBX1 (/IDA) |
Actin filament network formation GO:0051639
The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments.
|
1 | O75128 (/ISS) |
Actin crosslink formation GO:0051764
The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes.
|
1 | Q5NBX1 (/NAS) |
Auditory receptor cell stereocilium organization GO:0060088
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells.
|
1 | E7F568 (/IMP) |
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
|
1 | E7F568 (/IMP) |
Positive regulation of dendrite development GO:1900006
Any process that activates or increases the frequency, rate or extent of dendrite development.
|
1 | Q5NBX1 (/IDA) |
Positive regulation of dendrite development GO:1900006
Any process that activates or increases the frequency, rate or extent of dendrite development.
|
1 | O75128 (/ISS) |
Positive regulation of ruffle assembly GO:1900029
Any process that activates or increases the frequency, rate or extent of ruffle assembly.
|
1 | Q5NBX1 (/IDA) |
There are 24 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
2 | D3ZUI5 (/IDA) Q5NBX1 (/IDA) |
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
|
1 | Q5NBX1 (/IDA) |
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
|
1 | O75128 (/ISS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | D3ZUI5 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q5NBX1 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | O75128 (/ISS) |
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
1 | Q5NBX1 (/ISO) |
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
1 | O75128 (/ISS) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q5NBX1 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | O75128 (/ISS) |
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
1 | Q5NBX1 (/IDA) |
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
1 | O75128 (/ISS) |
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
1 | Q5NBX1 (/IDA) |
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
1 | O75128 (/ISS) |
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
1 | Q5NBX1 (/IDA) |
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
1 | O75128 (/ISS) |
Dendritic growth cone GO:0044294
The migrating motile tip of a growing nerve cell dendrite.
|
1 | Q5NBX1 (/IDA) |
Dendritic growth cone GO:0044294
The migrating motile tip of a growing nerve cell dendrite.
|
1 | O75128 (/ISS) |
Axonal growth cone GO:0044295
The migrating motile tip of a growing nerve cell axon.
|
1 | Q5NBX1 (/IDA) |
Axonal growth cone GO:0044295
The migrating motile tip of a growing nerve cell axon.
|
1 | O75128 (/ISS) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | Q5NBX1 (/IDA) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | O75128 (/ISS) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q53SF7 (/HDA) |
Terminal web GO:1990357
An actin-rich cytoskeletal network located beneath the microvilli of the apical plasma membrane of polarized epithelial cells. In addition to actin filaments, the terminal web may contain actin-binding proteins, myosin motor proteins, and intermediate filaments. The terminal web can function as a contractile structure that influences the spatial distribution of microvilli as well as the development and morphogenesis of tissues containing polarized epithelial cells.
|
1 | G5E8P4 (/IDA) |