CATH Superfamily 3.10.20.90
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
".
FunFam 62: talin-2 isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
8 | M9NDM3 (/IPI) M9PBW9 (/IPI) M9PEJ8 (/IPI) M9PF06 (/IPI) M9PF06 (/IPI) Q71LX4 (/IPI) Q9VSL8 (/IPI) Q9Y4G6 (/IPI) |
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
|
6 | M9NDM3 (/IPI) M9PBW9 (/IPI) M9PEJ8 (/IPI) M9PF06 (/IPI) M9PF06 (/IPI) Q9VSL8 (/IPI) |
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
1 | Q9Y4G6 (/NAS) |
Structural molecule activity GO:0005198
The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.
|
1 | Q9Y4G6 (/NAS) |
There are 26 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
|
8 | A0A0R4IDZ8 (/IMP) M9NDM3 (/IMP) M9PBW9 (/IMP) M9PEJ8 (/IMP) M9PF06 (/IMP) M9PF06 (/IMP) Q5U7N6 (/IMP) Q9VSL8 (/IMP) |
Cytoskeletal anchoring at plasma membrane GO:0007016
A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane.
|
6 | M9NDM3 (/ISS) M9PBW9 (/ISS) M9PEJ8 (/ISS) M9PF06 (/ISS) M9PF06 (/ISS) Q9VSL8 (/ISS) |
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
6 | M9NDM3 (/IMP) M9PBW9 (/IMP) M9PEJ8 (/IMP) M9PF06 (/IMP) M9PF06 (/IMP) Q9VSL8 (/IMP) |
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
6 | M9NDM3 (/TAS) M9PBW9 (/TAS) M9PEJ8 (/TAS) M9PF06 (/TAS) M9PF06 (/TAS) Q9VSL8 (/TAS) |
Border follicle cell migration GO:0007298
The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
|
6 | M9NDM3 (/IMP) M9PBW9 (/IMP) M9PEJ8 (/IMP) M9PF06 (/IMP) M9PF06 (/IMP) Q9VSL8 (/IMP) |
Germ-band shortening GO:0007390
The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo.
|
6 | M9NDM3 (/IMP) M9PBW9 (/IMP) M9PEJ8 (/IMP) M9PF06 (/IMP) M9PF06 (/IMP) Q9VSL8 (/IMP) |
Apposition of dorsal and ventral imaginal disc-derived wing surfaces GO:0007475
The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing.
|
6 | M9NDM3 (/IMP) M9PBW9 (/IMP) M9PEJ8 (/IMP) M9PF06 (/IMP) M9PF06 (/IMP) Q9VSL8 (/IMP) |
Larval somatic muscle development GO:0007526
The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure.
|
6 | M9NDM3 (/IMP) M9PBW9 (/IMP) M9PEJ8 (/IMP) M9PF06 (/IMP) M9PF06 (/IMP) Q9VSL8 (/IMP) |
Muscle attachment GO:0016203
The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).
|
6 | M9NDM3 (/IMP) M9PBW9 (/IMP) M9PEJ8 (/IMP) M9PF06 (/IMP) M9PF06 (/IMP) Q9VSL8 (/IMP) |
Cell adhesion mediated by integrin GO:0033627
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
|
6 | M9NDM3 (/IMP) M9PBW9 (/IMP) M9PEJ8 (/IMP) M9PF06 (/IMP) M9PF06 (/IMP) Q9VSL8 (/IMP) |
Maintenance of epithelial integrity, open tracheal system GO:0035160
Ensuring that tracheal tubes in an open tracheal system maintain their epithelial structure during the cell shape changes and movements that occur during the branching process.
|
6 | M9NDM3 (/IMP) M9PBW9 (/IMP) M9PEJ8 (/IMP) M9PF06 (/IMP) M9PF06 (/IMP) Q9VSL8 (/IMP) |
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
6 | M9NDM3 (/IMP) M9PBW9 (/IMP) M9PEJ8 (/IMP) M9PF06 (/IMP) M9PF06 (/IMP) Q9VSL8 (/IMP) |
Cardiac muscle cell-cardiac muscle cell adhesion GO:0086042
The attachment of one cardiomyocyte to another cardiomyocyte via adhesion molecules.
|
6 | M9NDM3 (/IMP) M9PBW9 (/IMP) M9PEJ8 (/IMP) M9PF06 (/IMP) M9PF06 (/IMP) Q9VSL8 (/IMP) |
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
|
2 | A0A0R4IDZ8 (/IMP) Q5U7N6 (/IMP) |
Neural crest cell differentiation GO:0014033
The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.
|
2 | A0A0R4IDZ8 (/IMP) Q5U7N6 (/IMP) |
Embryonic viscerocranium morphogenesis GO:0048703
The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones.
|
2 | A0A0R4IDZ8 (/IMP) Q5U7N6 (/IMP) |
Cardiac muscle cell development GO:0055013
The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.
|
2 | A0A0R4IDZ8 (/IGI) Q5U7N6 (/IGI) |
Cardiac muscle cell development GO:0055013
The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.
|
2 | A0A0R4IDZ8 (/IMP) Q5U7N6 (/IMP) |
Closure of optic fissure GO:0061386
The closure of the temporary ventral gap in the optic cup that contributes to its shaping.
|
2 | A0A0R4IDZ8 (/IMP) Q5U7N6 (/IMP) |
Cell-cell junction assembly GO:0007043
The aggregation, arrangement and bonding together of a set of components to form a junction between cells.
|
1 | Q9Y4G6 (/TAS) |
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
1 | Q9Y4G6 (/NAS) |
Terminal branching, open tracheal system GO:0007430
Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster.
|
1 | Q9VSL8 (/HMP) |
Lumen formation, open tracheal system GO:0035149
Creation of the central hole of a tube in an open tracheal system through which gases flow.
|
1 | Q9VSL8 (/HMP) |
Regulation of vulval development GO:0040028
Any process that modulates the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
|
1 | G5EGK1 (/IGI) |
Negative regulation of epidermal growth factor receptor signaling pathway GO:0042059
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
|
1 | G5EGK1 (/IMP) |
Vulval cell fate specification GO:0072327
The process in which a cell becomes capable of differentiating autonomously into a nematode vulval cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes.
|
1 | G5EGK1 (/IGI) |
There are 14 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
6 | M9NDM3 (/IDA) M9PBW9 (/IDA) M9PEJ8 (/IDA) M9PF06 (/IDA) M9PF06 (/IDA) Q9VSL8 (/IDA) |
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
6 | M9NDM3 (/ISS) M9PBW9 (/ISS) M9PEJ8 (/ISS) M9PF06 (/ISS) M9PF06 (/ISS) Q9VSL8 (/ISS) |
M band GO:0031430
The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.
|
2 | G5EGK1 (/IDA) Q95XN3 (/IDA) |
Striated muscle dense body GO:0055120
A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere.
|
2 | G5EGK1 (/IDA) Q95XN3 (/IDA) |
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
|
1 | G5EGK1 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | G5EGK1 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q9VSL8 (/HDA) |
Fascia adherens GO:0005916
A cell-cell adherens junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighboring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes.
|
1 | Q71LX4 (/IDA) |
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
1 | Q9Y4G6 (/HDA) |
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
1 | Q9Y4G6 (/NAS) |
Lateral plasma membrane GO:0016328
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
|
1 | G5EGK1 (/IDA) |
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
|
1 | Q9VSL8 (/HDA) |
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
|
1 | Q71LX4 (/IDA) |
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
|
1 | Q9Y4G6 (/NAS) |