The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 264: ISG15 ubiquitin-like modifier

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
5 O02741 (/ISS) O02741 (/ISS) O02741 (/ISS) Q64339 (/ISS) Q64339 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P05161 (/IPI) Q64339 (/IPI) Q64339 (/IPI)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
2 Q64339 (/ISO) Q64339 (/ISO)
Protein tag GO:0031386
A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation.
2 Q64339 (/IDA) Q64339 (/IDA)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 P05161 (/IPI)

There are 42 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to type I interferon GO:0034340
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
6 O02741 (/ISS) O02741 (/ISS) O02741 (/ISS) Q64339 (/ISS) Q64339 (/ISS) Q8AXA2 (/ISS)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
5 O02741 (/ISS) O02741 (/ISS) O02741 (/ISS) Q64339 (/ISS) Q64339 (/ISS)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
5 O02741 (/ISS) O02741 (/ISS) O02741 (/ISS) Q64339 (/ISS) Q64339 (/ISS)
Regulation of interferon-gamma production GO:0032649
Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
5 O02741 (/ISS) O02741 (/ISS) O02741 (/ISS) Q64339 (/ISS) Q64339 (/ISS)
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
5 O02741 (/ISS) O02741 (/ISS) O02741 (/ISS) Q64339 (/ISS) Q64339 (/ISS)
Interleukin-10 secretion GO:0072608
The regulated release of interleukin-10 from a cell.
5 O02741 (/ISS) O02741 (/ISS) O02741 (/ISS) Q64339 (/ISS) Q64339 (/ISS)
Interferon-gamma secretion GO:0072643
The regulated release of interferon-gamma from a cell.
5 O02741 (/ISS) O02741 (/ISS) O02741 (/ISS) Q64339 (/ISS) Q64339 (/ISS)
Positive regulation of bone mineralization GO:0030501
Any process that activates or increases the frequency, rate or extent of bone mineralization.
4 O02741 (/ISS) O02741 (/ISS) O02741 (/ISS) P05161 (/ISS)
ISG15-protein conjugation GO:0032020
The covalent addition to a protein of ISG15, a ubiquitin-like protein.
3 P05161 (/IDA) Q64339 (/IDA) Q64339 (/IDA)
ISG15-protein conjugation GO:0032020
The covalent addition to a protein of ISG15, a ubiquitin-like protein.
3 O02741 (/ISS) O02741 (/ISS) O02741 (/ISS)
Response to type I interferon GO:0034340
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
3 B5XFU9 (/IDA) P05161 (/IDA) Q29W12 (/IDA)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
3 P05161 (/IMP) Q64339 (/IMP) Q64339 (/IMP)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
3 O02741 (/ISS) O02741 (/ISS) O02741 (/ISS)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
3 P05161 (/IMP) Q64339 (/IMP) Q64339 (/IMP)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
3 O02741 (/ISS) O02741 (/ISS) O02741 (/ISS)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 Q64339 (/ISO) Q64339 (/ISO)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
2 Q64339 (/IEP) Q64339 (/IEP)
Modification-dependent protein catabolic process GO:0019941
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein.
2 Q64339 (/IDA) Q64339 (/IDA)
Positive regulation of bone mineralization GO:0030501
Any process that activates or increases the frequency, rate or extent of bone mineralization.
2 Q64339 (/IMP) Q64339 (/IMP)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
2 Q64339 (/ISO) Q64339 (/ISO)
ISG15-protein conjugation GO:0032020
The covalent addition to a protein of ISG15, a ubiquitin-like protein.
2 Q64339 (/ISO) Q64339 (/ISO)
Regulation of interferon-gamma production GO:0032649
Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
2 Q64339 (/ISO) Q64339 (/ISO)
Response to type I interferon GO:0034340
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
2 Q64339 (/ISO) Q64339 (/ISO)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
2 Q64339 (/ISO) Q64339 (/ISO)
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
2 Q64339 (/ISO) Q64339 (/ISO)
Positive regulation of erythrocyte differentiation GO:0045648
Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
2 Q64339 (/IMP) Q64339 (/IMP)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
2 B5XFU9 (/IDA) Q29W12 (/IDA)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
2 Q64339 (/ISO) Q64339 (/ISO)
Cellular response to type I interferon GO:0071357
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
2 B5XFU9 (/IDA) Q29W12 (/IDA)
Interleukin-10 secretion GO:0072608
The regulated release of interleukin-10 from a cell.
2 Q64339 (/ISO) Q64339 (/ISO)
Interferon-gamma secretion GO:0072643
The regulated release of interferon-gamma from a cell.
2 Q64339 (/ISO) Q64339 (/ISO)
Cellular response to virus GO:0098586
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
2 B5XFU9 (/IDA) Q29W12 (/IDA)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P05161 (/IDA)
Translesion synthesis GO:0019985
The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.
1 P05161 (/TAS)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
1 P05161 (/IDA)
ISG15-protein conjugation GO:0032020
The covalent addition to a protein of ISG15, a ubiquitin-like protein.
1 P05161 (/IMP)
Negative regulation of type I interferon production GO:0032480
Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
1 P05161 (/TAS)
Regulation of interferon-gamma production GO:0032649
Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
1 P05161 (/IMP)
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
1 P05161 (/IMP)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
1 P05161 (/TAS)
Interleukin-10 secretion GO:0072608
The regulated release of interleukin-10 from a cell.
1 P05161 (/IDA)
Interferon-gamma secretion GO:0072643
The regulated release of interferon-gamma from a cell.
1 P05161 (/IDA)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
5 O02741 (/ISS) O02741 (/ISS) O02741 (/ISS) Q64339 (/ISS) Q64339 (/ISS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 Q64339 (/ISO) Q64339 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 B5XFU9 (/IDA) Q29W12 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P05161 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P05161 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P05161 (/TAS)