CATH Superfamily 3.10.20.90
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
".
FunFam 170: Polycomb group RING finger protein 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | P23798 (/IPI) P35227 (/IPI) P35227 (/IPI) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
2 | P35227 (/TAS) P35227 (/TAS) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
1 | P23798 (/IDA) |
There are 15 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | P35227 (/IMP) P35227 (/IMP) |
|
Histone H2A-K119 monoubiquitination GO:0036353
The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms.
|
2 | P35227 (/IMP) P35227 (/IMP) |
|
Negative regulation of G0 to G1 transition GO:0070317
A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase.
|
2 | P35227 (/TAS) P35227 (/TAS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | P23798 (/IGI) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | P23798 (/ISO) |
|
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
|
1 | P23798 (/IGI) |
|
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
|
1 | P23798 (/IGI) |
|
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
|
1 | P23798 (/IMP) |
|
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
|
1 | P23798 (/IGI) |
|
Histone H2A-K119 monoubiquitination GO:0036353
The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms.
|
1 | P23798 (/ISO) |
|
Histone H2A-K119 monoubiquitination GO:0036353
The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms.
|
1 | P23798 (/ISS) |
|
Embryonic skeletal system morphogenesis GO:0048704
The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.
|
1 | P23798 (/IGI) |
|
Embryonic skeletal system development GO:0048706
The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.
|
1 | P23798 (/IGI) |
|
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
1 | P23798 (/IDA) |
|
Negative regulation of apoptotic signaling pathway GO:2001234
Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.
|
1 | P23798 (/IGI) |
There are 12 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | A0A024R1V6 (/IDA) A0A024R1V6 (/IDA) P23798 (/IDA) P35227 (/IDA) P35227 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | P23798 (/TAS) P35227 (/TAS) P35227 (/TAS) |
|
PcG protein complex GO:0031519
A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.
|
3 | P23798 (/IDA) P35227 (/IDA) P35227 (/IDA) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
2 | P35227 (/IDA) P35227 (/IDA) |
|
PRC1 complex GO:0035102
A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling.
|
2 | P35227 (/IDA) P35227 (/IDA) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
1 | P23798 (/ISO) |
|
Sex chromatin GO:0001739
Chromatin that is part of a sex chromosome.
|
1 | P23798 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P23798 (/ISO) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
1 | P23798 (/IDA) |
|
PcG protein complex GO:0031519
A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.
|
1 | P23798 (/ISO) |
|
PRC1 complex GO:0035102
A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling.
|
1 | P23798 (/ISO) |
|
PRC1 complex GO:0035102
A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling.
|
1 | P23798 (/ISS) |
