The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12: Serine/threonine-protein kinase WNK1 isoform 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 27 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P83741 (/IPI) Q9H4A3 (/IPI) Q9JIH7 (/IPI)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
3 P83741 (/ISS) Q6R2V0 (/ISS) Q9JIH7 (/ISS)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
2 Q9H4A3 (/IDA) Q9JIH7 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
2 Q9H4A3 (/ISS) Q9Y3S1 (/ISS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 Q9H4A3 (/IDA) Q9JIH7 (/IDA)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 Q9H4A3 (/IPI) Q9JIH7 (/IPI)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 Q9JIH7 (/IMP)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 P83741 (/ISO)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 P83741 (/IDA)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 Q9H4A3 (/IMP)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 P83741 (/ISO)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 P83741 (/IMP)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 P83741 (/ISO)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 Q9H4A3 (/TAS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P83741 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q9Y3S1 (/ISS)
Chloride channel inhibitor activity GO:0019869
Stops, prevents, or reduces the activity of a chloride channel.
1 Q9H4A3 (/IDA)
Chloride channel inhibitor activity GO:0019869
Stops, prevents, or reduces the activity of a chloride channel.
1 P83741 (/ISO)
Potassium channel inhibitor activity GO:0019870
Stops, prevents, or reduces the activity of a potassium channel.
1 Q9JIH7 (/IDA)
Potassium channel inhibitor activity GO:0019870
Stops, prevents, or reduces the activity of a potassium channel.
1 P83741 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 P83741 (/ISO)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
1 Q9H4A3 (/IDA)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
1 P83741 (/ISO)
Protein serine/threonine kinase inhibitor activity GO:0030291
Stops, prevents or reduces the activity of a protein serine/threonine kinase.
1 Q9JIH7 (/IDA)
Protein serine/threonine kinase inhibitor activity GO:0030291
Stops, prevents or reduces the activity of a protein serine/threonine kinase.
1 P83741 (/ISO)
Protein kinase activator activity GO:0030295
Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.
1 Q9H4A3 (/IMP)
Protein kinase activator activity GO:0030295
Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.
1 P83741 (/ISO)

There are 63 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
5 E7F2F9 (/IMP) F1Q6T6 (/IMP) F1R801 (/IMP) Q5RI61 (/IMP) X1WG08 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
5 P83741 (/IDA) Q3UH66 (/IDA) Q9H4A3 (/IDA) Q9JIH7 (/IDA) Q9Y3S1 (/IDA)
Negative regulation of phosphatase activity GO:0010923
Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
3 P83741 (/ISS) Q6R2V0 (/ISS) Q9JIH7 (/ISS)
Posterior lateral line neuromast development GO:0048919
The process whose specific outcome is the progression of the posterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals.
3 F1Q6T6 (/IGI) F1R801 (/IGI) Q5RI61 (/IGI)
Posterior lateral line neuromast development GO:0048919
The process whose specific outcome is the progression of the posterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals.
3 F1Q6T6 (/IMP) F1R801 (/IMP) Q5RI61 (/IMP)
Regulation of sodium ion transport GO:0002028
Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P83741 (/ISS) Q9H4A3 (/ISS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 P83741 (/ISO) Q3UH66 (/ISO)
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q9H4A3 (/ISS) Q9JIH7 (/ISS)
Negative regulation of GTPase activity GO:0034260
Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
2 P83741 (/IMP) Q9H4A3 (/IMP)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
2 Q9H4A3 (/IDA) Q9JIH7 (/IDA)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
2 Q9JIH7 (/IDA) Q9Y3S1 (/IDA)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
2 P83741 (/ISO) Q3UH66 (/ISO)
Regulation of cellular process GO:0050794
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
2 Q9H4A3 (/ISS) Q9JIH7 (/ISS)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
2 Q9H4A3 (/IMP) Q9Y3S1 (/IMP)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
2 P83741 (/ISO) Q3UH66 (/ISO)
Cellular response to chemokine GO:1990869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus.
2 P83741 (/IMP) Q9H4A3 (/IMP)
Regulation of sodium ion transport GO:0002028
Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9JIH7 (/IDA)
Regulation of sodium ion transport GO:0002028
Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P83741 (/ISO)
Positive regulation of systemic arterial blood pressure GO:0003084
The process that increases the force with which blood travels through the systemic arterial circulatory system.
1 P83741 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 Q9H4A3 (/IMP)
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P83741 (/IDA)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q9Y3S1 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q3UH66 (/ISO)
Negative regulation of sodium ion transport GO:0010766
Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P83741 (/ISO)
Positive regulation of T cell chemotaxis GO:0010820
Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.
1 Q9H4A3 (/IMP)
Positive regulation of T cell chemotaxis GO:0010820
Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.
1 P83741 (/ISO)
Negative regulation of phosphatase activity GO:0010923
Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
1 Q9H4A3 (/IDA)
Negative regulation of phosphatase activity GO:0010923
Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
1 P83741 (/ISO)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
1 P83741 (/IMP)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
1 Q9H4A3 (/ISS)
Peptidyl-threonine phosphorylation GO:0018107
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
1 Q9H4A3 (/TAS)
Signal transduction by trans-phosphorylation GO:0023016
A process in which the transfer of one or more phosphate groups by a kinase to a residue in a different protein molecule transmits a signal.
1 Q9H4A3 (/IDA)
Signal transduction by trans-phosphorylation GO:0023016
A process in which the transfer of one or more phosphate groups by a kinase to a residue in a different protein molecule transmits a signal.
1 P83741 (/ISO)
Negative regulation of cell-cell adhesion mediated by integrin GO:0033633
Any process that stops, prevents, or reduces the frequency, rate, or extent of cell-cell adhesion mediated by integrin.
1 Q9H4A3 (/IMP)
Negative regulation of cell-cell adhesion mediated by integrin GO:0033633
Any process that stops, prevents, or reduces the frequency, rate, or extent of cell-cell adhesion mediated by integrin.
1 P83741 (/ISO)
Negative regulation of kinase activity GO:0033673
Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
1 Q9JIH7 (/IDA)
Negative regulation of kinase activity GO:0033673
Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
1 P83741 (/ISO)
Negative regulation of heterotypic cell-cell adhesion GO:0034115
Any process that stops, prevents, or reduces the frequency, rate, or extent of heterotypic cell-cell adhesion.
1 Q9H4A3 (/IMP)
Negative regulation of heterotypic cell-cell adhesion GO:0034115
Any process that stops, prevents, or reduces the frequency, rate, or extent of heterotypic cell-cell adhesion.
1 P83741 (/ISO)
Negative regulation of GTPase activity GO:0034260
Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
1 P83741 (/ISO)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 P83741 (/ISO)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 Q9Y3S1 (/ISS)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 Q9H4A3 (/TAS)
Chemokine (C-C motif) ligand 21 signaling pathway GO:0038116
A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P83741 (/IMP)
Chemokine (C-C motif) ligand 21 signaling pathway GO:0038116
A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q9H4A3 (/ISS)
Neuron development GO:0048666
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
1 Q9H4A3 (/NAS)
Regulation of cellular process GO:0050794
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
1 P83741 (/IDA)
Ion homeostasis GO:0050801
Any process involved in the maintenance of an internal steady state of ions within an organism or cell.
1 Q9Y3S1 (/IMP)
Ion homeostasis GO:0050801
Any process involved in the maintenance of an internal steady state of ions within an organism or cell.
1 Q3UH66 (/ISO)
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
1 P83741 (/IMP)
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
1 Q9H4A3 (/ISS)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q9Y3S1 (/IMP)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q3UH66 (/ISO)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
1 Q9JIH7 (/IDA)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
1 P83741 (/ISO)
Negative regulation of pancreatic juice secretion GO:0090188
Any process that decreases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine.
1 P83741 (/IMP)
Lymphocyte migration into lymph node GO:0097022
The movement of a lymphocyte within the lymphatic system into a lymph node, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen.
1 P83741 (/IMP)
Lymphocyte migration into lymph node GO:0097022
The movement of a lymphocyte within the lymphatic system into a lymph node, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen.
1 Q9H4A3 (/ISS)
Negative regulation of leukocyte cell-cell adhesion GO:1903038
Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion.
1 Q9H4A3 (/IMP)
Negative regulation of leukocyte cell-cell adhesion GO:1903038
Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion.
1 P83741 (/ISO)
Cellular response to chemokine GO:1990869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus.
1 P83741 (/ISO)
Positive regulation of sodium ion transmembrane transporter activity GO:2000651
Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity.
1 Q9Y3S1 (/IMP)
Positive regulation of sodium ion transmembrane transporter activity GO:2000651
Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity.
1 Q3UH66 (/ISO)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 F5GWT4 (/IDA) F8W9F9 (/IDA) H0Y7R3 (/IDA) H0Y7T5 (/IDA) Q9H4A3 (/IDA) Q9JIH7 (/IDA) Q9Y3S1 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 P83741 (/IDA) Q9H4A3 (/IDA) Q9JIH7 (/IDA) Q9Y3S1 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P83741 (/ISO) Q3UH66 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P83741 (/ISO) Q3UH66 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9H4A3 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9JIH7 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P83741 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9H4A3 (/ISS)
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