View in Gene3D

CATH Superfamily 3.10.129.10

Hotdog Thioesterase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Hotdog Thioesterase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 61: Probable dehydrogenase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Enoyl-CoA hydratase 2. [EC: 4.2.1.119]
(3R)-3-hydroxyacyl-CoA = (2E)-2-enoyl-CoA + H(2)O.
  • This enzyme catalyzes a hydration step in peroxisomal beta-oxidation.
  • The human multifunctional enzyme type 2 (MFE-2) is a 79000 Da enzyme composed of three functional units: (3R)-hydroxyacyl-CoA dehydrogenase, 2-enoyl-CoA hydratase 2 and sterol carrier protein 2-like units.
  • The enzymes from Aeromonas caviae and Arabidopsis thaliana are monofunctional enzymes.
  • 2-enoyl-CoA hydratase 3 from Candida tropicalis is a part from multifunctional enzyme type 2.
 5 Q8VYI3 Q9VXJ0 Q9VXJ0 X2JFD6 X2JFD6
(3R)-hydroxyacyl-CoA dehydrogenase. [EC: 1.1.1.n12]
(R)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
    		 4 Q9VXJ0 Q9VXJ0 X2JFD6 X2JFD6