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CATH Superfamily 3.10.129.10

Hotdog Thioesterase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Hotdog Thioesterase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 201: Fluoroacetyl-CoA thioesterase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Fluoroacetyl-CoA thioesterase. [EC: 3.1.2.29]
Fluoroacetyl-CoA + H(2)O = fluoroacetate + CoA.
  • Fluoroacetate is extremely toxic.
  • It reacts with CoA to form fluoroacetyl-CoA, which substitutes for acetyl CoA and reacts with EC 2.3.3.1 to produce fluorocitrate, a metabolite of which binds very tightly to EC 4.2.1.3 and halts the TCA cycle.
  • This enzyme hydrolyzes fluoroacetyl-CoA before it can react with citrate synthase, and thus confers fluoroacetate resistance on the organisms that produce it.
  • It has been described in the poisonous plant Dichapetalum cymosum and the bacterium Streptomyces cattleya, both of which are fluoroacetate producers.
 4 F8JPF9 F8JPF9 Q1EMV2 Q1EMV2