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CATH Superfamily 3.10.120.10

Cytochrome b5-like heme/steroid binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome b5-like heme/steroid binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 41: Acyl-lipid omega-13 desaturase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Acyl-lipid omega-(9-4) desaturase. [EC: 1.14.19.12]
(1) Linoleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) = pinolenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H(2)O. (2) Alpha-linolenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) = coniferonoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H(2)O.
  • The enzyme, characterized from the green alga Chlamydomonas reinhardtii, is a front-end desaturase that introduces a cis double bond in omega(9) unsaturated C(18) or C(20) fatty acids incorporated into lipids, at a position 4 carbon atoms from the existing omega(9) bond, toward the carboxy end of the fatty acid (at the omega(13) position).
  • When acting on 20:2-Delta-(11,14) and 20:3-Delta-(11,14,17) substrates it introduces the new double bond between carbons 7 and 8.
  • The enzyme contains a cytochrome b5 domain that acts as the direct electron donor for the active site of the desaturase.
 4 A0A2K3DBB8 A0A2K3DBB8 Q2HWK7 Q2HWK7
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