The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome b5-like heme/steroid binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17: Fatty acid desaturase 1

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Acyl-CoA (8-3)-desaturase. [EC: 1.14.19.44]
(1) (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = arachidonoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O. (2) (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl- CoA + 2 ferricytochrome b5 + 2 H(2)O.
  • The enzyme introduces a cis double bond at carbon 5 of acyl-CoAs that contain a double bond at position 8.
  • The enzymes from algae, mosses, mammals and the protozoan Leishmania major catalyze the desaturation of dihomo-gamma-linoleate ((8Z,11Z,14Z)-icosa-8,11,14-trienoate) and (8Z,11Z,14Z,17Z)-icosa- 8,11,14,17-tetraenoate to generate arachidonate and (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate, respectively.
  • The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the desaturase active site and does not require an external cytochrome.
  • Cf. EC 1.14.19.37.
9 A0A2J8LDB7 A0A2J8LDB7 O60427 O60427 Q920L1 Q920L1 Q920R3 X2EXD0 X2EXD0
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