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CATH Superfamily 3.10.120.10

Cytochrome b5-like heme/steroid binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome b5-like heme/steroid binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: Delta-6 fatty acyl desaturase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Acyl-CoA 6-desaturase. [EC: 1.14.19.3]
(1) Linoleoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = gamma- linolenoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O. (2) Alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O.
  • The enzyme introduces a cis double bond at carbon 6 of acyl-CoAs.
  • It is a front-end desaturase, introducing the new double bond between a pre-existing double bond and the carboxyl-end of the fatty acid.
  • The human enzyme has a broad substrate range; it also acts on palmitoyl-CoA, generating sapienoyl-CoA, and on (9Z,12Z,15Z,18Z,21Z)- tetracosa-9,12,15,18,21-pentaenoyl-CoA, converting it to (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoyl-CoA as part of a pathway that produces docosahexaenoate.
  • The enzyme contains a cytochrome b5 domain that is assumed to act in vivo as the electron donor to the active site of the desaturase.
 16 A0A2J8SMN3 A0A2J8SMN3 A0A2R9BKZ6 A0A2R9BKZ6 A0A2R9BKZ6 H2Q3U8 H2Q3U8 H2Q3U8 O95864 O95864
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