The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ubiquitin Conjugating Enzyme
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: NEDD8-conjugating enzyme Ubc12

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
90 A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS)
(80 more)
NEDD8 transferase activity GO:0019788
Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.
90 A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS)
(80 more)
NEDD8 transferase activity GO:0019788
Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.
49 P52491 (/IDA) P52491 (/IDA) P52491 (/IDA) P52491 (/IDA) P61081 (/IDA) P61081 (/IDA) P61081 (/IDA) P61081 (/IDA) P61081 (/IDA) P61081 (/IDA)
(39 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
48 P52491 (/IPI) P52491 (/IPI) P52491 (/IPI) P52491 (/IPI) P61081 (/IPI) P61081 (/IPI) P61081 (/IPI) P61081 (/IPI) P61081 (/IPI) P61081 (/IPI)
(38 more)
NEDD8 transferase activity GO:0019788
Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.
44 P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS)
(34 more)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
41 P61081 (/IMP) P61081 (/IMP) P61081 (/IMP) P61081 (/IMP) P61081 (/IMP) P61081 (/IMP) P61081 (/IMP) P61081 (/IMP) P61081 (/IMP) P61081 (/IMP)
(31 more)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
41 P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO)
(31 more)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
41 P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS)
(31 more)
NEDD8 transferase activity GO:0019788
Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.
41 P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO)
(31 more)
NEDD8 transferase activity GO:0019788
Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.
4 P52491 (/IMP) P52491 (/IMP) P52491 (/IMP) P52491 (/IMP)
NEDD8 conjugating enzyme activity GO:0061654
Isoenergetic transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y -> Y-NEDD8 + X, where both the X-NEDD8 and Y-NEDD8 linkages are thioester bonds between the C-terminal amino acid of NEDD8 and a sulfhydryl side group of a cysteine residue.
1 O74549 (/ISO)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular protein modification process GO:0006464
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
90 A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS)
(80 more)
Protein neddylation GO:0045116
Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
90 A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS) A3KN22 (/ISS)
(80 more)
Protein neddylation GO:0045116
Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
49 P52491 (/IDA) P52491 (/IDA) P52491 (/IDA) P52491 (/IDA) P61081 (/IDA) P61081 (/IDA) P61081 (/IDA) P61081 (/IDA) P61081 (/IDA) P61081 (/IDA)
(39 more)
Protein neddylation GO:0045116
Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
42 O74549 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO)
(32 more)
Cellular protein modification process GO:0006464
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
41 P61081 (/IMP) P61081 (/IMP) P61081 (/IMP) P61081 (/IMP) P61081 (/IMP) P61081 (/IMP) P61081 (/IMP) P61081 (/IMP) P61081 (/IMP) P61081 (/IMP)
(31 more)
Cellular protein modification process GO:0006464
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
41 P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO)
(31 more)
Cellular protein modification process GO:0006464
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
41 P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS)
(31 more)
Positive regulation of neuron apoptotic process GO:0043525
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
41 D3ZNQ6 (/IMP) D3ZNQ6 (/IMP) D3ZNQ6 (/IMP) D3ZNQ6 (/IMP) D3ZNQ6 (/IMP) D3ZNQ6 (/IMP) D3ZNQ6 (/IMP) D3ZNQ6 (/IMP) D3ZNQ6 (/IMP) D3ZNQ6 (/IMP)
(31 more)
Positive regulation of neuron apoptotic process GO:0043525
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
41 P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO) P61082 (/ISO)
(31 more)
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
41 P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS)
(31 more)
Protein neddylation GO:0045116
Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
4 P52491 (/IMP) P52491 (/IMP) P52491 (/IMP) P52491 (/IMP)
Negative regulation of smoothened signaling pathway GO:0045879
Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
4 Q9VSF3 (/IMP) Q9VSF3 (/IMP) Q9VSF3 (/IMP) Q9VSF3 (/IMP)
Response to auxin GO:0009733
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus.
3 Q9SDY5 (/IMP) Q9SDY5 (/IMP) Q9SDY5 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
41 P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS)
(31 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
41 P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS) P61081 (/TAS)
(31 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O74549 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O74549 (/HDA)