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CATH Superfamily 3.10.110.10

Ubiquitin Conjugating Enzyme

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ubiquitin Conjugating Enzyme
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 33: NEDD8-conjugating enzyme UBE2F

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 15 Q969M7 (/IPI) Q969M7 (/IPI) Q969M7 (/IPI) Q969M7 (/IPI) Q969M7 (/IPI) Q969M7 (/IPI) Q969M7 (/IPI) Q969M7 (/IPI) Q969M7 (/IPI) Q969M7 (/IPI)
(5 more)
NEDD8 transferase activity GO:0019788
Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.
 15 Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS)
(5 more)
NEDD8 conjugating enzyme activity GO:0061654
Isoenergetic transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y -> Y-NEDD8 + X, where both the X-NEDD8 and Y-NEDD8 linkages are thioester bonds between the C-terminal amino acid of NEDD8 and a sulfhydryl side group of a cysteine residue.
 15 Q969M7 (/IDA) Q969M7 (/IDA) Q969M7 (/IDA) Q969M7 (/IDA) Q969M7 (/IDA) Q969M7 (/IDA) Q969M7 (/IDA) Q969M7 (/IDA) Q969M7 (/IDA) Q969M7 (/IDA)
(5 more)
NEDD8 conjugating enzyme activity GO:0061654
Isoenergetic transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y -> Y-NEDD8 + X, where both the X-NEDD8 and Y-NEDD8 linkages are thioester bonds between the C-terminal amino acid of NEDD8 and a sulfhydryl side group of a cysteine residue.
 10 Q1RMW1 (/ISS) Q1RMW1 (/ISS) Q1RMW1 (/ISS) Q3UWQ3 (/ISS) Q5M8Y2 (/ISS) Q5U203 (/ISS) Q5ZKX6 (/ISS) Q6IRC7 (/ISS) Q6IRC7 (/ISS) Q6NY82 (/ISS)
NEDD8 transferase activity GO:0019788
Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.
 2 Q9CY34 (/IMP) Q9CY34 (/IMP)
NEDD8 conjugating enzyme activity GO:0061654
Isoenergetic transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y -> Y-NEDD8 + X, where both the X-NEDD8 and Y-NEDD8 linkages are thioester bonds between the C-terminal amino acid of NEDD8 and a sulfhydryl side group of a cysteine residue.
 2 Q9CY34 (/ISO) Q9CY34 (/ISO)
NEDD8 transferase activity GO:0019788
Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.
 1 Q9XVK5 (/IDA)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein neddylation GO:0045116
Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
 16 Q969M7 (/IDA) Q969M7 (/IDA) Q969M7 (/IDA) Q969M7 (/IDA) Q969M7 (/IDA) Q969M7 (/IDA) Q969M7 (/IDA) Q969M7 (/IDA) Q969M7 (/IDA) Q969M7 (/IDA)
(6 more)
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
 15 Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS)
(5 more)
Protein neddylation GO:0045116
Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
 10 Q1RMW1 (/ISS) Q1RMW1 (/ISS) Q1RMW1 (/ISS) Q3UWQ3 (/ISS) Q5M8Y2 (/ISS) Q5U203 (/ISS) Q5ZKX6 (/ISS) Q6IRC7 (/ISS) Q6IRC7 (/ISS) Q6NY82 (/ISS)
Protein neddylation GO:0045116
Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
 2 Q9CY34 (/IMP) Q9CY34 (/IMP)
Protein neddylation GO:0045116
Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
 2 Q9CY34 (/ISO) Q9CY34 (/ISO)
Negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518
Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
 1 Q9XVK5 (/IMP)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 15 Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS) Q969M7 (/TAS)
(5 more)