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CATH Superfamily 3.10.110.10

Ubiquitin Conjugating Enzyme

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ubiquitin Conjugating Enzyme
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 22: Ubiquitin-conjugating enzyme E2 W

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
N-terminal E2 ubiquitin-conjugating enzyme. [EC: 2.3.2.25]
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L- cysteine + N-terminal-ubiquitinyl-[acceptor protein].
  • The enzyme ubiquitinylates the N-terminus of the acceptor protein.
  • It is not reactive toward free lysine.
 294 A0A0D9RM42 A0A0D9RM42 A0A0D9RM42 A0A0D9RM42 A0A0D9RM42 A0A0D9RM42 A0A0D9RM42 A0A0D9RM42 A0A0D9RM42 A0A0D9RM42
(284 more...)
E2 ubiquitin-conjugating enzyme. [EC: 2.3.2.23]
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L- cysteine.
  • The E2 ubiquitin-conjugating enzyme acquires the activated ubquitin from the E1 ubiquitin-activating enzyme (EC 6.2.1.45) and binds it via a transthioesterification reaction to itself.
  • In the human enzyme the catalytic center is located at Cys-87 where ubiquitin is bound via its C-terminal glycine in a thioester linkage.
  • Formerly EC 6.3.2.19.
 294 A0A0D9RM42 A0A0D9RM42 A0A0D9RM42 A0A0D9RM42 A0A0D9RM42 A0A0D9RM42 A0A0D9RM42 A0A0D9RM42 A0A0D9RM42 A0A0D9RM42
(284 more...)
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