The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ubiquitin Conjugating Enzyme
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Ubiquitin-conjugating enzyme 28, E2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
29 F4JKF3 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15732 (/IDA) P15732 (/IDA)
(19 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
17 P15731 (/IPI) P15731 (/IPI) P15731 (/IPI) P15731 (/IPI) P15731 (/IPI) P15731 (/IPI) P15731 (/IPI) P15732 (/IPI) P15732 (/IPI) P15732 (/IPI)
(7 more)
Proteasome binding GO:0070628
Interacting selectively and non-covalently with a proteasome, a large multisubunit protein complex that catalyzes protein degradation.
11 P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15732 (/IDA) P15732 (/IDA) P15732 (/IDA)
(1 more)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
8 A0A1D8PU40 (/ISS) A0A1D8PU40 (/ISS) A0A1D8PU40 (/ISS) A0A1D8PU40 (/ISS) A0A1D8PU40 (/ISS) P35131 (/ISS) P35131 (/ISS) P43102 (/ISS)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
7 P15731 (/IMP) P15731 (/IMP) P15731 (/IMP) P15731 (/IMP) P15731 (/IMP) P15731 (/IMP) P15731 (/IMP)
Protein binding, bridging GO:0030674
The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
7 P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA)
Ubiquitin binding GO:0043130
Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
7 P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA)
Ubiquitin binding GO:0043130
Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
7 P15731 (/IMP) P15731 (/IMP) P15731 (/IMP) P15731 (/IMP) P15731 (/IMP) P15731 (/IMP) P15731 (/IMP)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
5 P35133 (/IPI) P35133 (/IPI) P35133 (/IPI) P35133 (/IPI) P35133 (/IPI)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
2 Q84K64 (/IGI) Q84K93 (/IGI)
Showing 1 to 10 of 11 entries

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
14 F4JKF3 (/IDA) P35131 (/IDA) P35131 (/IDA) P35133 (/IDA) P35133 (/IDA) P35133 (/IDA) P35133 (/IDA) P35133 (/IDA) P35134 (/IDA) P35134 (/IDA)
(4 more)
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
11 P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15732 (/IDA) P15732 (/IDA) P15732 (/IDA)
(1 more)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
11 P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) Q8S919 (/IDA) Q8S920 (/IDA) Q8S920 (/IDA)
(1 more)
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
11 P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15732 (/IDA) P15732 (/IDA) P15732 (/IDA)
(1 more)
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
7 P15731 (/IMP) P15731 (/IMP) P15731 (/IMP) P15731 (/IMP) P15731 (/IMP) P15731 (/IMP) P15731 (/IMP)
Protein monoubiquitination GO:0006513
Addition of a single ubiquitin group to a protein.
7 P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA)
Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162
The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation.
7 P15731 (/IMP) P15731 (/IMP) P15731 (/IMP) P15731 (/IMP) P15731 (/IMP) P15731 (/IMP) P15731 (/IMP)
Cytoplasm protein quality control by the ubiquitin-proteasome system GO:0071629
The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are targeted to cytoplasmic proteasomes for degradation.
7 P15731 (/IMP) P15731 (/IMP) P15731 (/IMP) P15731 (/IMP) P15731 (/IMP) P15731 (/IMP) P15731 (/IMP)
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
2 Q84K64 (/IGI) Q84K93 (/IGI)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
2 P35131 (/TAS) P35131 (/TAS)
Showing 1 to 10 of 19 entries

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P35131 (/IDA) P35131 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P15731 (/IDA) P35131 (/IDA) P35131 (/IDA)
Proteasome complex GO:0000502
A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
2 Q84K64 (/IGI) Q84K93 (/IGI)
Showing 1 to 3 of 3 entries
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