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CATH Superfamily 2.70.240.20

Leukocidin/Hemolysin toxin, cytolysin domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Leukocidin/Hemolysin toxin, cytolysin domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Leukocidin/Hemolysin toxin, cytolysin domain

This superfamily includes the cytolysin domain and the beta-trefoil lectin domain characterised in Vibrio cholerae cytolysin (VCC) pro-toxin.

The cytolysin domain is the structural and functional core of the VCC molecule and has a fold strikingly similar to the Staph LukF water-soluble monomer and alpha-hemolysin protomer.

DOI:10.1016/j.jmb.2005.05.045

GO Diversity

Unique GO annotations
1 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
74 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 1
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Function
Unique EC:
Unique GO: 1
Taxonomy
Unique Species: 74
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