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CATH Superfamily 2.70.20.10

Topoisomerase I, domain 3

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Topoisomerase I, domain 3
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: DNA topoisomerase 3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA topoisomerase type I activity GO:0003917
Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
 29 P14294 (/IDA) P14294 (/IDA) P14294 (/IDA) P14294 (/IDA) P14294 (/IDA) P14294 (/IDA) P14294 (/IDA) P14294 (/IDA) P14294 (/IDA) P14294 (/IDA)
(19 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 29 P14294 (/IPI) P14294 (/IPI) P14294 (/IPI) P14294 (/IPI) P14294 (/IPI) P14294 (/IPI) P14294 (/IPI) P14294 (/IPI) P14294 (/IPI) P14294 (/IPI)
(19 more)

There are 2 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA recombination GO:0006310
Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
 29 P14294 (/IMP) P14294 (/IMP) P14294 (/IMP) P14294 (/IMP) P14294 (/IMP) P14294 (/IMP) P14294 (/IMP) P14294 (/IMP) P14294 (/IMP) P14294 (/IMP)
(19 more)
Chromosome separation GO:0051304
The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II).
 29 P14294 (/IMP) P14294 (/IMP) P14294 (/IMP) P14294 (/IMP) P14294 (/IMP) P14294 (/IMP) P14294 (/IMP) P14294 (/IMP) P14294 (/IMP) P14294 (/IMP)
(19 more)

There are 0 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.