CATH Superfamily 2.60.450.20
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 1: Centromere protein J
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | E7FCY1 (/IPI) Q569L8 (/IPI) Q9HC77 (/IPI) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | Q569L8 (/ISO) |
|
Tubulin binding GO:0015631
Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules.
|
1 | Q9HC77 (/IDA) |
|
Tubulin binding GO:0015631
Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules.
|
1 | Q569L8 (/ISO) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | Q9HC77 (/IPI) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | Q569L8 (/ISO) |
|
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
1 | Q9HC77 (/IPI) |
|
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
1 | Q569L8 (/ISO) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q9HC77 (/IPI) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q569L8 (/ISO) |
|
Gamma-tubulin binding GO:0043015
Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin.
|
1 | Q569L8 (/ISO) |
There are 32 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Centriole replication GO:0007099
The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0.
|
2 | Q569L8 (/ISS) Q5BQN8 (/ISS) |
|
Regulation of centriole replication GO:0046599
Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole.
|
2 | Q569L8 (/ISS) Q5BQN8 (/ISS) |
|
Centriole elongation GO:0061511
The centrosome organization process by which a centriole increases in length as part of the process of replication.
|
2 | Q569L8 (/ISS) Q5BQN8 (/ISS) |
|
Positive regulation of centriole elongation GO:1903724
Any process that activates or increases the frequency, rate or extent of centriole elongation.
|
2 | Q569L8 (/ISS) Q5BQN8 (/ISS) |
|
Positive regulation of establishment of protein localization GO:1904951
Any process that activates or increases the frequency, rate or extent of establishment of protein localization.
|
2 | Q569L8 (/ISS) Q5BQN8 (/ISS) |
|
G2/M transition of mitotic cell cycle GO:0000086
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
|
1 | Q9HC77 (/TAS) |
|
Microtubule nucleation GO:0007020
The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation).
|
1 | Q9HC77 (/TAS) |
|
Centriole replication GO:0007099
The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0.
|
1 | Q9HC77 (/IMP) |
|
Centriole replication GO:0007099
The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0.
|
1 | Q569L8 (/ISO) |
|
Smoothened signaling pathway GO:0007224
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
|
1 | Q569L8 (/IMP) |
|
Regulation of G2/M transition of mitotic cell cycle GO:0010389
Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
|
1 | Q9HC77 (/TAS) |
|
Astral microtubule nucleation GO:0030954
The 'de novo' formation of an astral microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule.
|
1 | Q569L8 (/ISO) |
|
Motile cilium assembly GO:0044458
The aggregation, arrangement and bonding together of a set of components to form a motile cilium.
|
1 | Q569L8 (/IMP) |
|
Positive regulation of receptor signaling pathway via JAK-STAT GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
|
1 | Q569L8 (/ISO) |
|
Regulation of centriole replication GO:0046599
Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole.
|
1 | Q9HC77 (/IMP) |
|
Regulation of centriole replication GO:0046599
Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole.
|
1 | Q569L8 (/ISO) |
|
Microtubule polymerization GO:0046785
The addition of tubulin heterodimers to one or both ends of a microtubule.
|
1 | Q9HC77 (/IMP) |
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Microtubule polymerization GO:0046785
The addition of tubulin heterodimers to one or both ends of a microtubule.
|
1 | Q569L8 (/ISO) |
|
Protein complex oligomerization GO:0051259
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
|
1 | E7FCY1 (/IDA) |
|
Centrosome duplication GO:0051298
The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
|
1 | Q569L8 (/IMP) |
|
Cell division GO:0051301
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
|
1 | Q9HC77 (/NAS) |
|
Centriole elongation GO:0061511
The centrosome organization process by which a centriole increases in length as part of the process of replication.
|
1 | Q9HC77 (/IDA) |
|
Centriole elongation GO:0061511
The centrosome organization process by which a centriole increases in length as part of the process of replication.
|
1 | Q569L8 (/ISO) |
|
Ciliary basal body-plasma membrane docking GO:0097711
The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane.
|
1 | Q9HC77 (/TAS) |
|
Centriole assembly GO:0098534
A cellular process that results in the assembly of one or more centrioles.
|
1 | Q569L8 (/IMP) |
|
Positive regulation of non-motile cilium assembly GO:1902857
Any process that activates or increases the frequency, rate or extent of non-motile cilium assembly.
|
1 | Q569L8 (/IMP) |
|
Mitotic spindle pole body duplication GO:1903087
Any spindle pole body duplication that is involved in the mitotic cell cycle.
|
1 | Q569L8 (/IMP) |
|
Positive regulation of centriole elongation GO:1903724
Any process that activates or increases the frequency, rate or extent of centriole elongation.
|
1 | Q9HC77 (/IMP) |
|
Positive regulation of centriole elongation GO:1903724
Any process that activates or increases the frequency, rate or extent of centriole elongation.
|
1 | Q569L8 (/ISO) |
|
Positive regulation of establishment of protein localization GO:1904951
Any process that activates or increases the frequency, rate or extent of establishment of protein localization.
|
1 | Q9HC77 (/IMP) |
|
Positive regulation of establishment of protein localization GO:1904951
Any process that activates or increases the frequency, rate or extent of establishment of protein localization.
|
1 | Q569L8 (/ISO) |
|
Non-motile cilium assembly GO:1905515
The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium.
|
1 | Q569L8 (/IMP) |
There are 13 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Centriole GO:0005814
A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
|
2 | Q569L8 (/IDA) Q9HC77 (/IDA) |
|
Centriole GO:0005814
A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
|
2 | Q569L8 (/ISS) Q5BQN8 (/ISS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q9HC77 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q569L8 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q569L8 (/ISO) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
1 | Q9HC77 (/IDA) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
1 | Q569L8 (/ISO) |
|
Centriole GO:0005814
A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
|
1 | Q569L8 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9HC77 (/TAS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q9HC77 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q569L8 (/ISO) |
|
Gamma-tubulin small complex GO:0008275
A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex.
|
1 | Q9HC77 (/NAS) |
|
Ciliary basal body GO:0036064
A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
|
1 | Q569L8 (/IDA) |