The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Transcription factor, T-box
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: T-box transcription factor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
6 B8JL25 (/IDA) O93303 (/IDA) O93389 (/IDA) P87377 (/IDA) P87377 (/IDA) Q504I8 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
5 B8JL25 (/IDA) O93303 (/IDA) O93389 (/IDA) P70327 (/IDA) Q504I8 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
4 O62535 (/IDA) P87377 (/IDA) P87377 (/IDA) Q9W3F4 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 O95947 (/IPI) P87377 (/IPI) P87377 (/IPI) Q8AV66 (/IPI)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
2 P87377 (/IPI) P87377 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 P87377 (/IDA) P87377 (/IDA)
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
1 P70327 (/IDA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 O95947 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 O95947 (/ISM)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 O95947 (/NAS)
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
1 P70327 (/IPI)
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
1 O95947 (/ISS)
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
1 P70327 (/IPI)
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
1 O95947 (/ISS)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 P70327 (/IC)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 O95947 (/TAS)

There are 58 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Somatic muscle development GO:0007525
The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle.
6 B8JL25 (/IMP) O62535 (/IMP) O93303 (/IMP) O93389 (/IMP) Q504I8 (/IMP) Q9W3F4 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
6 O62535 (/IDA) P70327 (/IDA) P87377 (/IDA) P87377 (/IDA) Q8AV66 (/IDA) Q9W3F4 (/IDA)
Paraxial mesoderm formation GO:0048341
The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
5 B8JL25 (/IGI) O93303 (/IGI) O93389 (/IGI) P79742 (/IGI) Q504I8 (/IGI)
Somite development GO:0061053
The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
5 B8JL25 (/IGI) O93303 (/IGI) O93389 (/IGI) P79742 (/IGI) Q504I8 (/IGI)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
4 B8JL25 (/IMP) O93303 (/IMP) O93389 (/IMP) Q504I8 (/IMP)
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
4 B8JL25 (/IMP) O93303 (/IMP) O93389 (/IMP) Q504I8 (/IMP)
Mesoderm formation GO:0001707
The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
4 P70327 (/IMP) P87377 (/IMP) P87377 (/IMP) Q8AV66 (/IMP)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
4 B8JL25 (/IGI) O93303 (/IGI) O93389 (/IGI) Q504I8 (/IGI)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
4 B8JL25 (/IMP) O93303 (/IMP) O93389 (/IMP) Q504I8 (/IMP)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
4 B8JL25 (/IGI) O93303 (/IGI) O93389 (/IGI) Q504I8 (/IGI)
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
4 B8JL25 (/IMP) O93303 (/IMP) O93389 (/IMP) Q504I8 (/IMP)
Embryonic heart tube morphogenesis GO:0003143
The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
4 B8JL25 (/IMP) O93303 (/IMP) O93389 (/IMP) Q504I8 (/IMP)
Determination of left/right symmetry GO:0007368
The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
4 B8JL25 (/IMP) O93303 (/IMP) O93389 (/IMP) Q504I8 (/IMP)
Mesoderm development GO:0007498
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
4 B8JL25 (/IGI) O93303 (/IGI) O93389 (/IGI) Q504I8 (/IGI)
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
4 B8JL25 (/IMP) O93303 (/IMP) O93389 (/IMP) Q504I8 (/IMP)
Pancreas development GO:0031016
The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes.
4 B8JL25 (/IGI) O93303 (/IGI) O93389 (/IGI) Q504I8 (/IGI)
Pronephric glomerulus morphogenesis GO:0035775
The process in which the anatomical structures of the pronephric glomerulus are generated and organized. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment.
4 B8JL25 (/IMP) O93303 (/IMP) O93389 (/IMP) Q504I8 (/IMP)
Pronephric duct morphogenesis GO:0039023
The process in which the anatomical structures of the pronephric duct are generated and organized. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the kidney.
4 B8JL25 (/IMP) O93303 (/IMP) O93389 (/IMP) Q504I8 (/IMP)
Regulation of endodermal cell fate specification GO:0042663
Any process that mediates the specification of a cell into an endoderm cell.
4 B8JL25 (/IGI) O93303 (/IGI) O93389 (/IGI) Q504I8 (/IGI)
Intermediate mesoderm development GO:0048389
The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads.
4 B8JL25 (/IMP) O93303 (/IMP) O93389 (/IMP) Q504I8 (/IMP)
Digestive tract development GO:0048565
The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.
4 B8JL25 (/IGI) O93303 (/IGI) O93389 (/IGI) Q504I8 (/IGI)
Pronephros development GO:0048793
The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.
4 B8JL25 (/IMP) O93303 (/IMP) O93389 (/IMP) Q504I8 (/IMP)
Erythrocyte development GO:0048821
The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure.
4 B8JL25 (/IMP) O93303 (/IMP) O93389 (/IMP) Q504I8 (/IMP)
Convergent extension involved in axis elongation GO:0060028
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism.
4 B8JL25 (/IMP) O93303 (/IMP) O93389 (/IMP) Q504I8 (/IMP)
Hematopoietic stem cell differentiation GO:0060218
The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
4 B8JL25 (/IMP) O93303 (/IMP) O93389 (/IMP) Q504I8 (/IMP)
Mesodermal to mesenchymal transition involved in gastrulation GO:0060809
The epithelial to mesenchymal transition process in which a mesodermal cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell as part of the process of gastrulation.
4 B8JL25 (/IMP) O93303 (/IMP) O93389 (/IMP) Q504I8 (/IMP)
Myeloid cell development GO:0061515
The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure.
4 B8JL25 (/IMP) O93303 (/IMP) O93389 (/IMP) Q504I8 (/IMP)
Kupffer's vesicle development GO:0070121
The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period.
4 B8JL25 (/IGI) O93303 (/IGI) O93389 (/IGI) Q504I8 (/IGI)
Convergent extension involved in nephron morphogenesis GO:0072045
The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron.
4 B8JL25 (/IMP) O93303 (/IMP) O93389 (/IMP) Q504I8 (/IMP)
Regulation of BMP signaling pathway involved in heart jogging GO:2000223
Any process that modulates the frequency, rate or extent of BMP signaling pathway involved in heart jogging.
4 B8JL25 (/IMP) O93303 (/IMP) O93389 (/IMP) Q504I8 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
3 P87377 (/IDA) P87377 (/IDA) Q8AV66 (/IDA)
Cell fate specification GO:0001708
The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.
2 P70327 (/IMP) P90971 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 P87377 (/IDA) P87377 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 P87377 (/IMP) P87377 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P70327 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 O95947 (/ISS)
Mesoderm formation GO:0001707
The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
1 Q66JL1 (/ISS)
Mesoderm development GO:0007498
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
1 O95947 (/TAS)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
1 Q8AV66 (/IPI)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
1 Q66JL1 (/ISS)
Anatomical structure morphogenesis GO:0009653
The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
1 O95947 (/TAS)
Embryonic pattern specification GO:0009880
The process that results in the patterns of cell differentiation that will arise in an embryo.
1 Q8AV66 (/IMP)
Embryonic pattern specification GO:0009880
The process that results in the patterns of cell differentiation that will arise in an embryo.
1 Q66JL1 (/ISS)
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
1 Q8AV66 (/IMP)
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
1 Q66JL1 (/ISS)
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P70327 (/IGI)
Negative regulation of neuron maturation GO:0014043
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation.
1 P70327 (/IGI)
Signal transduction involved in regulation of gene expression GO:0023019
Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another.
1 P70327 (/IDA)
Positive regulation of Wnt signaling pathway GO:0030177
Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
1 Q8AV66 (/IMP)
Positive regulation of Wnt signaling pathway GO:0030177
Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
1 Q66JL1 (/ISS)
Somite rostral/caudal axis specification GO:0032525
The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary.
1 P70327 (/IDA)
Locomotion GO:0040011
Self-propelled movement of a cell or organism from one location to another.
1 P90971 (/IMP)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 P70327 (/IDA)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 O95947 (/ISS)
Nematode male tail tip morphogenesis GO:0045138
The process in which the anatomical structure of the adult male tail tip is generated and organized. In some species of rhabitid nematodes, the male tail tip undergoes a morphological change such that the most posterior hypodermal cells in the tail (hyp8-11 in C. elegans) fuse and retract anteriorly, changing the shape of the tail from a pointed, tapered cone, or spike, to a rounded, blunt dome.
1 P90971 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q66JL1 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q66JL1 (/ISS)
Post-embryonic hindgut morphogenesis GO:0048620
The process in which the anatomical structures of the hindgut are generated and organized, during the post-embryonic phase.
1 P90971 (/IMP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 B8JL25 (/IDA) O93303 (/IDA) O93389 (/IDA) P70327 (/IDA) P87377 (/IDA) P87377 (/IDA) P90971 (/IDA) Q504I8 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
5 B8JL25 (/IDA) O93303 (/IDA) O93389 (/IDA) P70327 (/IDA) Q504I8 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O62535 (/IC) Q9W3F4 (/IC)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
2 P87377 (/IPI) P87377 (/IPI)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8AV66 (/NAS)
Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
1 Q8AV66 (/IPI)
Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
1 Q66JL1 (/ISS)
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