The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 14: Alpha-2-macroglobulin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endopeptidase inhibitor activity GO:0004866
Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
9 P76578 (/IDA) P76578 (/IDA) P76578 (/IDA) P76578 (/IDA) P76578 (/IDA) P76578 (/IDA) P76578 (/IDA) P76578 (/IDA) P76578 (/IDA)

There are 1 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of endopeptidase activity GO:0010951
Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
9 P76578 (/IDA) P76578 (/IDA) P76578 (/IDA) P76578 (/IDA) P76578 (/IDA) P76578 (/IDA) P76578 (/IDA) P76578 (/IDA) P76578 (/IDA)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Anchored component of external side of plasma membrane GO:0031362
The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
9 P76578 (/IDA) P76578 (/IDA) P76578 (/IDA) P76578 (/IDA) P76578 (/IDA) P76578 (/IDA) P76578 (/IDA) P76578 (/IDA) P76578 (/IDA)