The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Protein-arginine deiminase, N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Protein-arginine deiminase type-2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-arginine deiminase activity GO:0004668
Catalysis of the reaction: protein L-arginine + H2O = protein L-citrulline + NH3.
5 P20717 (/IDA) Q9Y2J8 (/IDA) Q9Y2J8 (/IDA) Q9Y2J8 (/IDA) Q9Y2J8 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
4 Q9Y2J8 (/IDA) Q9Y2J8 (/IDA) Q9Y2J8 (/IDA) Q9Y2J8 (/IDA)
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
4 Q9Y2J8 (/IPI) Q9Y2J8 (/IPI) Q9Y2J8 (/IPI) Q9Y2J8 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
4 Q9Y2J8 (/IDA) Q9Y2J8 (/IDA) Q9Y2J8 (/IDA) Q9Y2J8 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 P20717 (/ISS) Q08642 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P20717 (/ISS) Q08642 (/ISS)
Protein-arginine deiminase activity GO:0004668
Catalysis of the reaction: protein L-arginine + H2O = protein L-citrulline + NH3.
1 Q08642 (/ISO)
Protein-arginine deiminase activity GO:0004668
Catalysis of the reaction: protein L-arginine + H2O = protein L-citrulline + NH3.
1 Q08642 (/ISS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q08642 (/ISO)
Arginine deiminase activity GO:0016990
Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3.
1 G1T837 (/IDA)
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
1 Q08642 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q08642 (/ISO)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein citrullination GO:0018101
The hydrolysis of peptidyl-arginine to form peptidyl-citrulline.
6 G1T837 (/IDA) P20717 (/IDA) Q9Y2J8 (/IDA) Q9Y2J8 (/IDA) Q9Y2J8 (/IDA) Q9Y2J8 (/IDA)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
4 Q9Y2J8 (/TAS) Q9Y2J8 (/TAS) Q9Y2J8 (/TAS) Q9Y2J8 (/TAS)
Regulation of chromatin disassembly GO:0010848
Any process that modulates the frequency, rate or extent of chromatin disassembly. Chromatin disassembly is the controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, and other proteins.
4 Q9Y2J8 (/IDA) Q9Y2J8 (/IDA) Q9Y2J8 (/IDA) Q9Y2J8 (/IDA)
Substantia nigra development GO:0021762
The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis).
4 Q9Y2J8 (/HEP) Q9Y2J8 (/HEP) Q9Y2J8 (/HEP) Q9Y2J8 (/HEP)
Intracellular estrogen receptor signaling pathway GO:0030520
Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription).
4 Q9Y2J8 (/IMP) Q9Y2J8 (/IMP) Q9Y2J8 (/IMP) Q9Y2J8 (/IMP)
Histone H3-R26 citrullination GO:0036413
The hydrolysis of peptidyl-arginine to form peptidyl-citrulline at position 26 in histone H3.
4 Q9Y2J8 (/IDA) Q9Y2J8 (/IDA) Q9Y2J8 (/IDA) Q9Y2J8 (/IDA)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
4 Q9Y2J8 (/TAS) Q9Y2J8 (/TAS) Q9Y2J8 (/TAS) Q9Y2J8 (/TAS)
Chromatin-mediated maintenance of transcription GO:0048096
Maintenance of transcription by remodelling of chromatin into an 'open configuration'. Once established, this regulation is mitotically stable and is maintained over many cell divisions. It is also heritable.
4 Q9Y2J8 (/IMP) Q9Y2J8 (/IMP) Q9Y2J8 (/IMP) Q9Y2J8 (/IMP)
Negative regulation of chemokine-mediated signaling pathway GO:0070100
Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor.
4 Q9Y2J8 (/IDA) Q9Y2J8 (/IDA) Q9Y2J8 (/IDA) Q9Y2J8 (/IDA)
Negative regulation of lymphocyte chemotaxis GO:1901624
Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte chemotaxis.
4 Q9Y2J8 (/IDA) Q9Y2J8 (/IDA) Q9Y2J8 (/IDA) Q9Y2J8 (/IDA)
Negative regulation of cell-matrix adhesion GO:0001953
Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix.
1 G1T837 (/IDA)
Regulation of chromatin disassembly GO:0010848
Any process that modulates the frequency, rate or extent of chromatin disassembly. Chromatin disassembly is the controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, and other proteins.
1 Q08642 (/ISO)
Protein citrullination GO:0018101
The hydrolysis of peptidyl-arginine to form peptidyl-citrulline.
1 Q08642 (/ISO)
Protein citrullination GO:0018101
The hydrolysis of peptidyl-arginine to form peptidyl-citrulline.
1 Q08642 (/ISS)
Intracellular estrogen receptor signaling pathway GO:0030520
Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription).
1 Q08642 (/ISO)
Histone H3-R26 citrullination GO:0036413
The hydrolysis of peptidyl-arginine to form peptidyl-citrulline at position 26 in histone H3.
1 Q08642 (/ISO)
Chromatin-mediated maintenance of transcription GO:0048096
Maintenance of transcription by remodelling of chromatin into an 'open configuration'. Once established, this regulation is mitotically stable and is maintained over many cell divisions. It is also heritable.
1 Q08642 (/ISO)
Negative regulation of chemokine-mediated signaling pathway GO:0070100
Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor.
1 Q08642 (/ISO)
Negative regulation of lymphocyte chemotaxis GO:1901624
Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte chemotaxis.
1 Q08642 (/ISO)
Cellular response to leukemia inhibitory factor GO:1990830
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
1 Q08642 (/IEP)
Negative regulation of integrin-mediated signaling pathway GO:2001045
Any process that stops, prevents or reduces the frequency, rate or extent of integrin-mediated signaling pathway.
1 G1T837 (/IDA)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
4 Q9Y2J8 (/TAS) Q9Y2J8 (/TAS) Q9Y2J8 (/TAS) Q9Y2J8 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q9Y2J8 (/IDA) Q9Y2J8 (/IDA) Q9Y2J8 (/IDA) Q9Y2J8 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 Q9Y2J8 (/TAS) Q9Y2J8 (/TAS) Q9Y2J8 (/TAS) Q9Y2J8 (/TAS)
Transcriptionally active chromatin GO:0035327
The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed.
4 Q9Y2J8 (/IDA) Q9Y2J8 (/IDA) Q9Y2J8 (/IDA) Q9Y2J8 (/IDA)
Azurophil granule lumen GO:0035578
The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
4 Q9Y2J8 (/TAS) Q9Y2J8 (/TAS) Q9Y2J8 (/TAS) Q9Y2J8 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
4 Q9Y2J8 (/HDA) Q9Y2J8 (/HDA) Q9Y2J8 (/HDA) Q9Y2J8 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q08642 (/ISO)
Transcriptionally active chromatin GO:0035327
The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed.
1 Q08642 (/ISO)
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