The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Na, k-atpase alpha subunit.
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: Sodium/potassium-transporting ATPase subunit beta

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sodium:potassium-exchanging ATPase activity GO:0005391
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
6 P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) Q63377 (/IDA)
Sodium:potassium-exchanging ATPase activity GO:0005391
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
6 P54709 (/TAS) P54709 (/TAS) P54709 (/TAS) P54709 (/TAS) P54709 (/TAS) Q63377 (/TAS)
ATPase activator activity GO:0001671
Binds to and increases the ATP hydrolysis activity of an ATPase.
5 P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA)
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
5 P54709 (/IPI) P54709 (/IPI) P54709 (/IPI) P54709 (/IPI) P54709 (/IPI)
ATPase activator activity GO:0001671
Binds to and increases the ATP hydrolysis activity of an ATPase.
2 P97370 (/ISO) P97370 (/ISO)
Sodium:potassium-exchanging ATPase activity GO:0005391
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
2 P97370 (/ISO) P97370 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P97370 (/IPI) P97370 (/IPI)
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
2 P97370 (/ISO) P97370 (/ISO)
Sodium:potassium-exchanging ATPase activity GO:0005391
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
1 Q63377 (/IC)

There are 31 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular sodium ion homeostasis GO:0006883
Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.
5 P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA)
Cellular potassium ion homeostasis GO:0030007
Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.
5 P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA)
Positive regulation of ATPase activity GO:0032781
Any process that activates or increases the rate of ATP hydrolysis by an ATPase.
5 P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
5 P54709 (/TAS) P54709 (/TAS) P54709 (/TAS) P54709 (/TAS) P54709 (/TAS)
Sodium ion export across plasma membrane GO:0036376
The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.
5 P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
5 P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA)
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
5 P54709 (/TAS) P54709 (/TAS) P54709 (/TAS) P54709 (/TAS) P54709 (/TAS)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
5 P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA)
Membrane repolarization GO:0086009
The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential.
5 P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA)
Positive regulation of potassium ion transmembrane transporter activity GO:1901018
Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity.
5 P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA)
Positive regulation of sodium ion export across plasma membrane GO:1903278
Any process that activates or increases the frequency, rate or extent of sodium ion export across the plasma membrane.
5 P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA)
Positive regulation of potassium ion import across plasma membrane GO:1903288
Any process that activates or increases the frequency, rate or extent of potassium ion import across the plasma membrane.
5 P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA)
Regulation of cardiac conduction GO:1903779
Any process that modulates the frequency, rate or extent of cardiac conduction.
5 P54709 (/TAS) P54709 (/TAS) P54709 (/TAS) P54709 (/TAS) P54709 (/TAS)
Potassium ion import across plasma membrane GO:1990573
The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
5 P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA)
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P97370 (/ISO) P97370 (/ISO)
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P97370 (/ISO) P97370 (/ISO)
Cellular sodium ion homeostasis GO:0006883
Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.
2 P97370 (/ISO) P97370 (/ISO)
Metal ion transport GO:0030001
The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P97370 (/ISO) P97370 (/ISO)
Cellular potassium ion homeostasis GO:0030007
Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.
2 P97370 (/ISO) P97370 (/ISO)
Positive regulation of ATPase activity GO:0032781
Any process that activates or increases the rate of ATP hydrolysis by an ATPase.
2 P97370 (/ISO) P97370 (/ISO)
Sodium ion export across plasma membrane GO:0036376
The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.
2 P97370 (/ISO) P97370 (/ISO)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
2 P97370 (/ISO) P97370 (/ISO)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
2 P97370 (/ISO) P97370 (/ISO)
Membrane repolarization GO:0086009
The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential.
2 P97370 (/ISO) P97370 (/ISO)
Positive regulation of potassium ion transmembrane transporter activity GO:1901018
Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity.
2 P97370 (/ISO) P97370 (/ISO)
Positive regulation of sodium ion export across plasma membrane GO:1903278
Any process that activates or increases the frequency, rate or extent of sodium ion export across the plasma membrane.
2 P97370 (/ISO) P97370 (/ISO)
Positive regulation of potassium ion import across plasma membrane GO:1903288
Any process that activates or increases the frequency, rate or extent of potassium ion import across the plasma membrane.
2 P97370 (/ISO) P97370 (/ISO)
Potassium ion import across plasma membrane GO:1990573
The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
2 P97370 (/ISO) P97370 (/ISO)
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q63377 (/IDA)
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q63377 (/IDA)
Metal ion transport GO:0030001
The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q63377 (/IDA)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) Q63377 (/IDA)
Sodium:potassium-exchanging ATPase complex GO:0005890
Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.
6 P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) P54709 (/IDA) Q63377 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P54709 (/TAS) P54709 (/TAS) P54709 (/TAS) P54709 (/TAS) P54709 (/TAS)
Sodium:potassium-exchanging ATPase complex GO:0005890
Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.
5 P54709 (/TAS) P54709 (/TAS) P54709 (/TAS) P54709 (/TAS) P54709 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
5 P54709 (/HDA) P54709 (/HDA) P54709 (/HDA) P54709 (/HDA) P54709 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P97370 (/IDA) P97370 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P97370 (/ISO) P97370 (/ISO)
Sodium:potassium-exchanging ATPase complex GO:0005890
Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.
2 P97370 (/ISO) P97370 (/ISO)
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
2 P97370 (/ISO) P97370 (/ISO)
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
1 Q63377 (/IDA)
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