The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"ntegrin, alpha v. Chain A, domain 4
".
FunFam 14: Integrin alpha 2b
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | P08514 (/IPI) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | P08514 (/IPI) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q9QUM0 (/ISO) |
|
Extracellular matrix binding GO:0050840
Interacting selectively and non-covalently with a component of the extracellular matrix.
|
1 | Q9QUM0 (/IMP) |
|
Fibrinogen binding GO:0070051
Interacting selectively and non-covalently with fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade.
|
1 | D3ZAC0 (/IDA) |
|
Fibrinogen binding GO:0070051
Interacting selectively and non-covalently with fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade.
|
1 | Q9QUM0 (/ISO) |
There are 9 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
|
1 | P08514 (/TAS) |
|
Positive regulation of leukocyte migration GO:0002687
Any process that activates or increases the frequency, rate, or extent of leukocyte migration.
|
1 | D3ZAC0 (/IMP) |
|
Positive regulation of leukocyte migration GO:0002687
Any process that activates or increases the frequency, rate, or extent of leukocyte migration.
|
1 | Q9QUM0 (/ISO) |
|
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
|
1 | Q9QUM0 (/IMP) |
|
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | P08514 (/HDA) |
|
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
|
1 | P08514 (/TAS) |
|
Regulation of megakaryocyte differentiation GO:0045652
Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.
|
1 | P08514 (/TAS) |
|
Platelet aggregation GO:0070527
The adhesion of one platelet to one or more other platelets via adhesion molecules.
|
1 | D3ZAC0 (/IMP) |
|
Platelet aggregation GO:0070527
The adhesion of one platelet to one or more other platelets via adhesion molecules.
|
1 | Q9QUM0 (/ISO) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
2 | D3ZAC0 (/IDA) Q9QUM0 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P08514 (/TAS) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
1 | Q9QUM0 (/IDA) |
|
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
1 | Q9QUM0 (/IDA) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | P08514 (/HDA) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | Q9QUM0 (/ISO) |
|
Platelet alpha granule membrane GO:0031092
The lipid bilayer surrounding the platelet alpha granule.
|
1 | P08514 (/TAS) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | P08514 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q9QUM0 (/ISO) |
|
Blood microparticle GO:0072562
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.
|
1 | P08514 (/HDA) |
