The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
C2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 20: C2 calcium dependent domain containing 5

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium-dependent phospholipid binding GO:0005544
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
3 Q28BX9 (/ISS) Q5RDC8 (/ISS) Q7TPS5 (/ISS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 Q7TPS5 (/IDA) Q86YS7 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 Q28BX9 (/ISS) Q5RDC8 (/ISS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q7TPS5 (/ISO)
Calcium-dependent phospholipid binding GO:0005544
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
1 Q86YS7 (/IDA)
Calcium-dependent phospholipid binding GO:0005544
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
1 Q7TPS5 (/ISO)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of glucose transmembrane transport GO:0010828
Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 Q28BX9 (/ISS) Q5RDC8 (/ISS) Q86YS7 (/ISS)
Insulin receptor signaling pathway via phosphatidylinositol 3-kinase GO:0038028
The series of molecular signals generated as a consequence of the insulin receptor binding to its physiological ligand, where the signal is passed on via the phosphatidylinositol 3-kinase cascade.
3 Q28BX9 (/ISS) Q5RDC8 (/ISS) Q86YS7 (/ISS)
Intracellular protein transmembrane transport GO:0065002
The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.
3 Q28BX9 (/ISS) Q5RDC8 (/ISS) Q7TPS5 (/ISS)
Positive regulation of protein targeting to membrane GO:0090314
Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
3 Q28BX9 (/ISS) Q5RDC8 (/ISS) Q7TPS5 (/ISS)
Positive regulation of vesicle fusion GO:0031340
Any process that activates or increases the frequency, rate or extent of vesicle fusion.
2 Q7TPS5 (/IMP) Q86YS7 (/IMP)
Positive regulation of vesicle fusion GO:0031340
Any process that activates or increases the frequency, rate or extent of vesicle fusion.
2 Q28BX9 (/ISS) Q5RDC8 (/ISS)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
2 Q7TPS5 (/IDA) Q86YS7 (/IDA)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
2 Q28BX9 (/ISS) Q5RDC8 (/ISS)
Vesicle fusion GO:0006906
Fusion of the membrane of a transport vesicle with its target membrane.
1 Q7TPS5 (/IMP)
Positive regulation of glucose transmembrane transport GO:0010828
Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q7TPS5 (/IMP)
Positive regulation of vesicle fusion GO:0031340
Any process that activates or increases the frequency, rate or extent of vesicle fusion.
1 Q7TPS5 (/ISO)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 Q7TPS5 (/ISO)
Insulin receptor signaling pathway via phosphatidylinositol 3-kinase GO:0038028
The series of molecular signals generated as a consequence of the insulin receptor binding to its physiological ligand, where the signal is passed on via the phosphatidylinositol 3-kinase cascade.
1 Q7TPS5 (/IMP)
Positive regulation of glucose import GO:0046326
Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
1 Q7TPS5 (/IGI)
Positive regulation of glucose import GO:0046326
Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
1 Q7TPS5 (/IMP)
Intracellular protein transmembrane transport GO:0065002
The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.
1 Q86YS7 (/IMP)
Intracellular protein transmembrane transport GO:0065002
The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.
1 Q7TPS5 (/ISO)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
1 Q7TPS5 (/IGI)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
1 Q7TPS5 (/IMP)
Positive regulation of protein targeting to membrane GO:0090314
Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
1 Q86YS7 (/IMP)
Positive regulation of protein targeting to membrane GO:0090314
Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
1 Q7TPS5 (/ISO)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
3 Q28BX9 (/ISS) Q5RDC8 (/ISS) Q7TPS5 (/ISS)
Cytoplasmic vesicle membrane GO:0030659
The lipid bilayer surrounding a cytoplasmic vesicle.
3 Q28BX9 (/ISS) Q5RDC8 (/ISS) Q7TPS5 (/ISS)
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
3 Q28BX9 (/ISS) Q5RDC8 (/ISS) Q7TPS5 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q7TPS5 (/IDA) Q86YS7 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q28BX9 (/ISS) Q5RDC8 (/ISS)
Microtubule organizing center GO:0005815
An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
1 Q86YS7 (/IDA)
Microtubule organizing center GO:0005815
An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
1 Q7TPS5 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q86YS7 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q7TPS5 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q7TPS5 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q7TPS5 (/TAS)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
1 Q86YS7 (/IDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
1 Q7TPS5 (/ISO)
Cytoplasmic vesicle membrane GO:0030659
The lipid bilayer surrounding a cytoplasmic vesicle.
1 Q86YS7 (/IDA)
Cytoplasmic vesicle membrane GO:0030659
The lipid bilayer surrounding a cytoplasmic vesicle.
1 Q7TPS5 (/ISO)
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
1 Q86YS7 (/IDA)
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
1 Q7TPS5 (/ISO)
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