The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"C2 domain
".
FunFam 181: Synaptotagmin 4
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
SNARE binding GO:0000149
Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
|
3 | Q8SYD5 (/IPI) Q9U6P7 (/IPI) Q9U6P7 (/IPI) |
|
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
|
3 | Q8SYD5 (/IDA) Q9U6P7 (/IDA) Q9U6P7 (/IDA) |
|
Calcium-dependent phospholipid binding GO:0005544
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
|
3 | Q8SYD5 (/IDA) Q9U6P7 (/IDA) Q9U6P7 (/IDA) |
|
Calcium-dependent phospholipid binding GO:0005544
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
|
3 | Q8SYD5 (/NAS) Q9U6P7 (/NAS) Q9U6P7 (/NAS) |
There are 6 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
|
3 | Q8SYD5 (/NAS) Q9U6P7 (/NAS) Q9U6P7 (/NAS) |
|
Synaptic vesicle exocytosis GO:0016079
Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
|
3 | Q8SYD5 (/ISS) Q9U6P7 (/ISS) Q9U6P7 (/ISS) |
|
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
|
3 | Q8SYD5 (/NAS) Q9U6P7 (/NAS) Q9U6P7 (/NAS) |
|
Positive regulation of vesicle fusion GO:0031340
Any process that activates or increases the frequency, rate or extent of vesicle fusion.
|
3 | Q8SYD5 (/IDA) Q9U6P7 (/IDA) Q9U6P7 (/IDA) |
|
Regulation of neurotransmitter secretion GO:0046928
Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell.
|
3 | Q8SYD5 (/IMP) Q9U6P7 (/IMP) Q9U6P7 (/IMP) |
|
Regulation of synaptic plasticity GO:0048167
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
|
3 | Q8SYD5 (/IMP) Q9U6P7 (/IMP) Q9U6P7 (/IMP) |
There are 6 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
|
3 | Q8SYD5 (/ISS) Q9U6P7 (/ISS) Q9U6P7 (/ISS) |
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
3 | Q8SYD5 (/ISM) Q9U6P7 (/ISM) Q9U6P7 (/ISM) |
|
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
3 | Q8SYD5 (/IDA) Q9U6P7 (/IDA) Q9U6P7 (/IDA) |
|
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
|
3 | Q8SYD5 (/IDA) Q9U6P7 (/IDA) Q9U6P7 (/IDA) |
|
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
|
3 | Q8SYD5 (/IDA) Q9U6P7 (/IDA) Q9U6P7 (/IDA) |
|
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
|
3 | Q8SYD5 (/IDA) Q9U6P7 (/IDA) Q9U6P7 (/IDA) |
