The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
C2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 121: Synaptotagmin-like 4, isoform CRA_a

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 Q8VHQ7 (/IPI) Q96C24 (/IPI) Q96C24 (/IPI) Q96C24 (/IPI) Q9R0Q1 (/IPI) Q9R0Q1 (/IPI)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
5 Q71SF7 (/ISS) Q8VHQ7 (/ISS) Q96C24 (/ISS) Q96C24 (/ISS) Q96C24 (/ISS)
Neurexin family protein binding GO:0042043
Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals.
5 Q71SF7 (/ISS) Q8VHQ7 (/ISS) Q96C24 (/ISS) Q96C24 (/ISS) Q96C24 (/ISS)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
2 Q9R0Q1 (/IDA) Q9R0Q1 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 Q9R0Q1 (/NAS) Q9R0Q1 (/NAS)
Neurexin family protein binding GO:0042043
Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals.
2 Q9R0Q1 (/IDA) Q9R0Q1 (/IDA)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane repair GO:0001778
The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress.
3 Q96C24 (/IDA) Q96C24 (/IDA) Q96C24 (/IDA)
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
3 Q96C24 (/TAS) Q96C24 (/TAS) Q96C24 (/TAS)
Lysosome localization GO:0032418
Any process in which a lysosome is transported to, and/or maintained in, a specific location.
3 Q96C24 (/IMP) Q96C24 (/IMP) Q96C24 (/IMP)
Positive regulation of exocytosis GO:0045921
Any process that activates or increases the frequency, rate or extent of exocytosis.
3 Q96C24 (/IMP) Q96C24 (/IMP) Q96C24 (/IMP)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
3 Q96C24 (/IMP) Q96C24 (/IMP) Q96C24 (/IMP)
Multivesicular body sorting pathway GO:0071985
A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded.
3 Q96C24 (/IMP) Q96C24 (/IMP) Q96C24 (/IMP)
Regulation of plasma membrane repair GO:1905684
Any process that modulates the frequency, rate or extent of plasma membrane repair.
3 Q96C24 (/IMP) Q96C24 (/IMP) Q96C24 (/IMP)
Plasma membrane repair GO:0001778
The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress.
2 Q9R0Q1 (/ISO) Q9R0Q1 (/ISO)
Exocytosis GO:0006887
A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
2 Q9R0Q1 (/IDA) Q9R0Q1 (/IDA)
Exocytosis GO:0006887
A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
2 Q71SF7 (/ISS) Q8VHQ7 (/ISS)
Lysosome localization GO:0032418
Any process in which a lysosome is transported to, and/or maintained in, a specific location.
2 Q9R0Q1 (/ISO) Q9R0Q1 (/ISO)
Positive regulation of exocytosis GO:0045921
Any process that activates or increases the frequency, rate or extent of exocytosis.
2 Q9R0Q1 (/ISO) Q9R0Q1 (/ISO)
Negative regulation of insulin secretion GO:0046676
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
2 Q9R0Q1 (/IMP) Q9R0Q1 (/IMP)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
2 Q9R0Q1 (/ISO) Q9R0Q1 (/ISO)
Multivesicular body sorting pathway GO:0071985
A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded.
2 Q9R0Q1 (/ISO) Q9R0Q1 (/ISO)
Regulation of plasma membrane repair GO:1905684
Any process that modulates the frequency, rate or extent of plasma membrane repair.
2 Q9R0Q1 (/ISO) Q9R0Q1 (/ISO)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
6 A0A024RCF8 (/IDA) A0A024RCF8 (/IDA) A0A024RCF8 (/IDA) Q96C24 (/IDA) Q96C24 (/IDA) Q96C24 (/IDA)
Microtubule organizing center GO:0005815
An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
6 A0A024RCF8 (/IDA) A0A024RCF8 (/IDA) A0A024RCF8 (/IDA) Q96C24 (/IDA) Q96C24 (/IDA) Q96C24 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 A0A024RCF8 (/IDA) A0A024RCF8 (/IDA) A0A024RCF8 (/IDA) Q96C24 (/IDA) Q96C24 (/IDA) Q96C24 (/IDA)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
5 Q71SF7 (/ISS) Q8VHQ7 (/ISS) Q96C24 (/ISS) Q96C24 (/ISS) Q96C24 (/ISS)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
3 Q96C24 (/IDA) Q96C24 (/IDA) Q96C24 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q96C24 (/TAS) Q96C24 (/TAS) Q96C24 (/TAS)
Platelet alpha granule membrane GO:0031092
The lipid bilayer surrounding the platelet alpha granule.
3 Q96C24 (/TAS) Q96C24 (/TAS) Q96C24 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q9R0Q1 (/ISO) Q9R0Q1 (/ISO)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
2 Q9R0Q1 (/ISO) Q9R0Q1 (/ISO)
Microtubule organizing center GO:0005815
An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
2 Q9R0Q1 (/ISO) Q9R0Q1 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9R0Q1 (/ISO) Q9R0Q1 (/ISO)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 Q9R0Q1 (/ISO) Q9R0Q1 (/ISO)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
2 Q9R0Q1 (/IDA) Q9R0Q1 (/IDA)
Secretory granule GO:0030141
A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
2 Q9R0Q1 (/IDA) Q9R0Q1 (/IDA)
Secretory granule membrane GO:0030667
The lipid bilayer surrounding a secretory granule.
2 Q9R0Q1 (/ISO) Q9R0Q1 (/ISO)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 Q8VHQ7 (/IDA)
Secretory granule membrane GO:0030667
The lipid bilayer surrounding a secretory granule.
1 Q8VHQ7 (/IDA)
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