The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Integrin domains. Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: integrin alpha-3 isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 18 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 D3ZCG9 (/IPI) D3ZQM3 (/IPI) P26006 (/IPI) P26006 (/IPI) Q62470 (/IPI)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
3 F1MMS9 (/ISS) P17852 (/ISS) Q62470 (/ISS)
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
2 D3ZCG9 (/IDA) D3ZQM3 (/IDA)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
2 P26006 (/IPI) P26006 (/IPI)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
2 D3ZCG9 (/IPI) D3ZQM3 (/IPI)
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
2 D3ZCG9 (/IDA) D3ZQM3 (/IDA)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
2 D3ZCG9 (/IMP) D3ZQM3 (/IMP)
Laminin binding GO:0043236
Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.
2 D3ZCG9 (/IDA) D3ZQM3 (/IDA)
Laminin binding GO:0043236
Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.
2 D3ZCG9 (/IMP) D3ZQM3 (/IMP)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 P26006 (/IDA) P26006 (/IDA)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 D3ZCG9 (/IPI) D3ZQM3 (/IPI)
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
1 Q62470 (/ISO)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
1 Q62470 (/ISO)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 Q62470 (/ISO)
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
1 Q62470 (/ISO)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 Q62470 (/ISO)
Laminin binding GO:0043236
Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.
1 Q62470 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q62470 (/ISO)

There are 46 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
3 F1MMS9 (/ISS) P17852 (/ISS) Q62470 (/ISS)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
2 D3ZCG9 (/IMP) D3ZQM3 (/IMP)
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
2 P26006 (/TAS) P26006 (/TAS)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
2 D3ZCG9 (/IEP) D3ZQM3 (/IEP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 D3ZCG9 (/IDA) D3ZQM3 (/IDA)
Positive regulation of epithelial cell migration GO:0010634
Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
2 D3ZCG9 (/IMP) D3ZQM3 (/IMP)
Positive regulation of cell-substrate adhesion GO:0010811
Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
2 D3ZCG9 (/IMP) D3ZQM3 (/IMP)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
2 D3ZCG9 (/IMP) D3ZQM3 (/IMP)
Regulation of transforming growth factor beta receptor signaling pathway GO:0017015
Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway.
2 P26006 (/IMP) P26006 (/IMP)
Regulation of Wnt signaling pathway GO:0030111
Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway.
2 P26006 (/IMP) P26006 (/IMP)
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
2 P26006 (/TAS) P26006 (/TAS)
Lung development GO:0030324
The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
2 P26006 (/IMP) P26006 (/IMP)
Regulation of BMP signaling pathway GO:0030510
Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.
2 P26006 (/IMP) P26006 (/IMP)
Negative regulation of cell projection organization GO:0031345
Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
2 D3ZCG9 (/IMP) D3ZQM3 (/IMP)
Response to gonadotropin GO:0034698
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus.
2 D3ZCG9 (/IEP) D3ZQM3 (/IEP)
Negative regulation of Rho protein signal transduction GO:0035024
Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
2 P26006 (/ISS) P26006 (/ISS)
Exploration behavior GO:0035640
The specific behavior of an organism in response to a novel environment or stimulus.
2 P26006 (/ISS) P26006 (/ISS)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
2 D3ZCG9 (/IEP) D3ZQM3 (/IEP)
Skin development GO:0043588
The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.
2 P26006 (/IMP) P26006 (/IMP)
Mesodermal cell differentiation GO:0048333
The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell.
2 P26006 (/IEP) P26006 (/IEP)
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
2 P26006 (/TAS) P26006 (/TAS)
Maternal process involved in female pregnancy GO:0060135
A reproductive process occurring in the mother that allows an embryo or fetus to develop within it.
2 D3ZCG9 (/IEP) D3ZQM3 (/IEP)
Nephron development GO:0072006
The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney.
2 P26006 (/IMP) P26006 (/IMP)
Dendritic spine maintenance GO:0097062
The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.
2 P26006 (/ISS) P26006 (/ISS)
Renal filtration GO:0097205
A renal system process in which fluid circulating through the body is filtered through a barrier system.
2 P26006 (/IMP) P26006 (/IMP)
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
2 P26006 (/IDA) P26006 (/IDA)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
1 Q62470 (/IMP)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 Q62470 (/ISO)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
1 Q62470 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q62470 (/ISO)
Positive regulation of epithelial cell migration GO:0010634
Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
1 Q62470 (/ISO)
Positive regulation of cell-substrate adhesion GO:0010811
Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
1 Q62470 (/ISO)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q62470 (/ISO)
Regulation of transforming growth factor beta receptor signaling pathway GO:0017015
Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway.
1 Q62470 (/ISO)
Regulation of Wnt signaling pathway GO:0030111
Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway.
1 Q62470 (/ISO)
Lung development GO:0030324
The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
1 Q62470 (/ISO)
Regulation of BMP signaling pathway GO:0030510
Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.
1 Q62470 (/ISO)
Negative regulation of cell projection organization GO:0031345
Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
1 Q62470 (/ISO)
Negative regulation of Rho protein signal transduction GO:0035024
Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
1 Q62470 (/IGI)
Exploration behavior GO:0035640
The specific behavior of an organism in response to a novel environment or stimulus.
1 Q62470 (/IGI)
Skin development GO:0043588
The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.
1 Q62470 (/ISO)
Nephron development GO:0072006
The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney.
1 Q62470 (/ISO)
Dendritic spine maintenance GO:0097062
The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.
1 Q62470 (/IGI)
Dendritic spine maintenance GO:0097062
The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.
1 Q62470 (/IMP)
Renal filtration GO:0097205
A renal system process in which fluid circulating through the body is filtered through a barrier system.
1 Q62470 (/ISO)
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
1 Q62470 (/ISO)

There are 35 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 D3ZCG9 (/IDA) D3ZQM3 (/IDA) P26006 (/IDA) P26006 (/IDA) Q62470 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
4 D3ZCG9 (/IDA) D3ZQM3 (/IDA) P26006 (/IDA) P26006 (/IDA)
Integrin alpha3-beta1 complex GO:0034667
An integrin complex that comprises one alpha3 subunit and one beta1 subunit.
4 D3ZCG9 (/IDA) D3ZQM3 (/IDA) P26006 (/IDA) P26006 (/IDA)
Filopodium membrane GO:0031527
The portion of the plasma membrane surrounding a filopodium.
3 F1MMS9 (/ISS) P17852 (/ISS) Q62470 (/ISS)
Invadopodium membrane GO:0071438
The portion of the plasma membrane surrounding an invadopodium.
3 F1MMS9 (/ISS) P17852 (/ISS) Q62470 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P26006 (/TAS) P26006 (/TAS)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
2 P26006 (/HDA) P26006 (/HDA)
Integrin complex GO:0008305
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
2 P26006 (/TAS) P26006 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 P26006 (/HDA) P26006 (/HDA)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
2 D3ZCG9 (/IDA) D3ZQM3 (/IDA)
Filopodium membrane GO:0031527
The portion of the plasma membrane surrounding a filopodium.
2 P26006 (/IDA) P26006 (/IDA)
Integrin alpha3-beta1 complex GO:0034667
An integrin complex that comprises one alpha3 subunit and one beta1 subunit.
2 P26006 (/IMP) P26006 (/IMP)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2 P26006 (/IDA) P26006 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 D3ZCG9 (/IDA) D3ZQM3 (/IDA)
Excitatory synapse GO:0060076
A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.
2 P26006 (/ISS) P26006 (/ISS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P26006 (/HDA) P26006 (/HDA)
Invadopodium membrane GO:0071438
The portion of the plasma membrane surrounding an invadopodium.
2 P26006 (/IDA) P26006 (/IDA)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
2 P26006 (/IDA) P26006 (/IDA)
Synaptic membrane GO:0097060
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
2 P26006 (/ISS) P26006 (/ISS)
Growth cone filopodium GO:1990812
A thin, stiff protrusion extended by the leading edge of an axonal or dendritic growth cone.
2 D3ZCG9 (/IDA) D3ZQM3 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q62470 (/ISO)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 Q62470 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q62470 (/ISO)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 Q62470 (/IDA)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
1 Q62470 (/ISO)
Filopodium membrane GO:0031527
The portion of the plasma membrane surrounding a filopodium.
1 Q62470 (/ISO)
Integrin alpha3-beta1 complex GO:0034667
An integrin complex that comprises one alpha3 subunit and one beta1 subunit.
1 Q62470 (/ISO)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q62470 (/ISO)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 Q62470 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q62470 (/ISO)
Excitatory synapse GO:0060076
A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.
1 Q62470 (/IDA)
Invadopodium membrane GO:0071438
The portion of the plasma membrane surrounding an invadopodium.
1 Q62470 (/ISO)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
1 Q62470 (/ISO)
Synaptic membrane GO:0097060
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
1 Q62470 (/IDA)
Growth cone filopodium GO:1990812
A thin, stiff protrusion extended by the leading edge of an axonal or dendritic growth cone.
1 Q62470 (/ISO)
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