The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Lamin Tail domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Lamin A/C

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 P02545 (/IPI) P02545 (/IPI) P02545 (/IPI) P48678 (/IPI) P48679 (/IPI) Q03252 (/IPI)
Protein phosphatase 1 binding GO:0008157
Interacting selectively and non-covalently with the enzyme protein phosphatase 1.
1 P48679 (/IPI)
Protein phosphatase 1 binding GO:0008157
Interacting selectively and non-covalently with the enzyme protein phosphatase 1.
1 P48678 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P48678 (/ISO)

There are 44 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein localization to nucleus GO:0034504
A process in which a protein transports or maintains the localization of another protein to the nucleus.
5 P02545 (/ISS) P02545 (/ISS) P02545 (/ISS) P48679 (/ISS) Q3ZD69 (/ISS)
Negative regulation of cardiac muscle hypertrophy in response to stress GO:1903243
Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle hypertrophy in response to stress.
5 P02545 (/ISS) P02545 (/ISS) P02545 (/ISS) P48679 (/ISS) Q3ZD69 (/ISS)
Mitotic nuclear envelope reassembly GO:0007084
The cell cycle process that results in reformation of the nuclear envelope during mitotic cell division.
3 P02545 (/TAS) P02545 (/TAS) P02545 (/TAS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
3 P02545 (/IMP) P02545 (/IMP) P02545 (/IMP)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
3 P02545 (/ISS) P02545 (/ISS) P02545 (/ISS)
Establishment or maintenance of microtubule cytoskeleton polarity GO:0030951
Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures.
3 P02545 (/ISS) P02545 (/ISS) P02545 (/ISS)
IRE1-mediated unfolded protein response GO:0036498
A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.
3 P02545 (/TAS) P02545 (/TAS) P02545 (/TAS)
Heart contraction GO:0060047
The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.
3 A0A2R8QPG3 (/IMP) B3DKC5 (/IMP) Q90XD7 (/IMP)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
3 P02545 (/IEP) P02545 (/IEP) P02545 (/IEP)
Regulation of cell aging GO:0090342
Any process that modulates the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan.
3 A0A2R8QPG3 (/IMP) B3DKC5 (/IMP) Q90XD7 (/IMP)
Positive regulation of cell aging GO:0090343
Any process that increases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan.
3 P02545 (/IDA) P02545 (/IDA) P02545 (/IDA)
Positive regulation of cell aging GO:0090343
Any process that increases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan.
3 P48678 (/ISS) P48679 (/ISS) Q3ZD69 (/ISS)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
1 P48678 (/IMP)
Nucleus organization GO:0006997
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.
1 P48678 (/IGI)
Nucleus organization GO:0006997
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.
1 P48678 (/IMP)
Nuclear envelope organization GO:0006998
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.
1 P48678 (/IGI)
Nuclear envelope organization GO:0006998
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.
1 P48678 (/ISO)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 P48679 (/IEP)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
1 P48678 (/ISO)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
1 P48678 (/ISS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 P48678 (/ISO)
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 P48679 (/IEP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P48678 (/IMP)
Establishment of cell polarity GO:0030010
The specification and formation of anisotropic intracellular organization or cell growth patterns.
1 P48678 (/NAS)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
1 P48678 (/IMP)
Establishment or maintenance of microtubule cytoskeleton polarity GO:0030951
Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures.
1 P48678 (/IMP)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
1 P48678 (/IMP)
Regulation of telomere maintenance GO:0032204
Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.
1 P48678 (/ISO)
Protein localization to nucleus GO:0034504
A process in which a protein transports or maintains the localization of another protein to the nucleus.
1 P48678 (/IMP)
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
1 P48678 (/ISO)
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
1 P48679 (/IMP)
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
1 P48678 (/ISO)
Ventricular cardiac muscle cell development GO:0055015
The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ.
1 P48678 (/IMP)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P48678 (/ISS)
Negative regulation of mesenchymal cell proliferation GO:0072201
Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.
1 P48678 (/IMP)
Negative regulation of release of cytochrome c from mitochondria GO:0090201
Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
1 P48678 (/IMP)
Positive regulation of cell aging GO:0090343
Any process that increases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan.
1 P48678 (/ISO)
Cellular senescence GO:0090398
A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.
1 P48679 (/IEP)
Positive regulation of histone H3-K9 trimethylation GO:1900114
Any process that activates or increases the frequency, rate or extent of histone H3-K9 trimethylation.
1 P48678 (/IMP)
Regulation of protein localization to nucleus GO:1900180
Any process that modulates the frequency, rate or extent of protein localization to nucleus.
1 P48678 (/IMP)
Negative regulation of cardiac muscle hypertrophy in response to stress GO:1903243
Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle hypertrophy in response to stress.
1 P48678 (/IMP)
Negative regulation of adipose tissue development GO:1904178
Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development.
1 P48679 (/IMP)
Negative regulation of adipose tissue development GO:1904178
Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development.
1 P48678 (/ISO)
Negative regulation of extrinsic apoptotic signaling pathway GO:2001237
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.
1 P48678 (/IMP)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
8 B3DFN3 (/IDA) P02545 (/IDA) P02545 (/IDA) P02545 (/IDA) P11048 (/IDA) P21619 (/IDA) P48678 (/IDA) Q9W6T5 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 P02545 (/IDA) P02545 (/IDA) P02545 (/IDA) P21619 (/IDA) P48678 (/IDA) P48679 (/IDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
4 P02545 (/TAS) P02545 (/TAS) P02545 (/TAS) P48678 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 P02545 (/TAS) P02545 (/TAS) P02545 (/TAS) P48678 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P02545 (/HDA) P02545 (/HDA) P02545 (/HDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 P02545 (/IDA) P02545 (/IDA) P02545 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P02545 (/TAS) P02545 (/TAS) P02545 (/TAS)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
3 P02545 (/HDA) P02545 (/HDA) P02545 (/HDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
2 P48679 (/ISS) Q3ZD69 (/ISS)
Lamin filament GO:0005638
Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C.
2 P21619 (/IDA) P48678 (/IDA)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
2 P48678 (/IDA) Q03252 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P48678 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q3ZD69 (/ISS)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 P48678 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P48678 (/ISO)
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
1 P48679 (/IDA)
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
1 P48678 (/ISO)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
1 P21619 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 P48678 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 P48678 (/ISS)
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