View in Gene3D

CATH Superfamily 2.60.40.1180

Golgi alpha-mannosidase II

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Golgi alpha-mannosidase II
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 22: Glucosidase II alpha subunit

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Mannosyl-oligosaccharide alpha-1,3-glucosidase. [EC: 3.2.1.207]
(1) Glc(2)Man(9)GlcNAc(2)-[protein] + H(2)O = GlcMan(9)GlcNAc(2)- [protein] + beta-D-glucopyranose. (2) GlcMan(9)GlcNAc(2)-[protein] + H(2)O = Man(9)GlcNAc(2)-[protein] + beta-D-glucopyranose.
  • This eukaryotic enzyme cleaves off sequentially the two alpha-1,3- linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature N-glycosylated proteins.
 5 Q14697 Q14697 Q4R4N7 V9HWJ0 V9HWJ0
Alpha-glucosidase. [EC: 3.2.1.20]
Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.
  • Group of enzymes whose specificity is directed mainly toward the exohydrolysis of 1,4-alpha-glucosidic linkages, and that hydrolyze oligosaccharides rapidly, relative to polysaccharides, which are hydrolyzed relatively slowly, or not at all.
  • The intestinal enzyme also hydrolyzes polysaccharides, catalyzing the reactions of EC 3.2.1.3, and, more slowly, hydrolyzes 1,6-alpha-D- glucose links.
 1 Q8BVW0
CATH-Gene3D is a Global Biodata Core Resource Learn more...