The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Immunoglobulins
".
FunFam 952: PZP, alpha-2-macroglobulin like
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
|
1 | P01023 (/IPI) |
|
Endopeptidase inhibitor activity GO:0004866
Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
|
1 | P20742 (/TAS) |
|
Serine-type endopeptidase inhibitor activity GO:0004867
Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.
|
1 | P01023 (/IDA) |
|
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | P01023 (/IMP) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | P01023 (/IPI) |
|
Growth factor binding GO:0019838
Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
|
1 | P01023 (/IDA) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
1 | P01023 (/IPI) |
|
Interleukin-8 binding GO:0019959
Interacting selectively and non-covalently with interleukin-8.
|
1 | P01023 (/IPI) |
|
Interleukin-1 binding GO:0019966
Interacting selectively and non-covalently with interleukin-1.
|
1 | P01023 (/IDA) |
|
Tumor necrosis factor binding GO:0043120
Interacting selectively and non-covalently with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages.
|
1 | P01023 (/IDA) |
|
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
|
1 | P01023 (/IPI) |
There are 6 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of complement activation, lectin pathway GO:0001869
Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway.
|
1 | P01023 (/IDA) |
|
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
|
1 | P01023 (/TAS) |
|
Female pregnancy GO:0007565
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
|
1 | P20742 (/TAS) |
|
Blood coagulation, intrinsic pathway GO:0007597
A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X.
|
1 | P01023 (/TAS) |
|
Extracellular matrix disassembly GO:0022617
A process that results in the breakdown of the extracellular matrix.
|
1 | P01023 (/TAS) |
|
Regulation of small GTPase mediated signal transduction GO:0051056
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
|
1 | P01023 (/TAS) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
2 | P01023 (/NAS) P20742 (/NAS) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
2 | P01023 (/HDA) P20742 (/HDA) |
|
Blood microparticle GO:0072562
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.
|
2 | P01023 (/HDA) P20742 (/HDA) |
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
1 | P01023 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P01023 (/TAS) |
|
Platelet alpha granule lumen GO:0031093
The volume enclosed by the membrane of the platelet alpha granule.
|
1 | P01023 (/TAS) |
|
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
|
1 | P01023 (/HDA) |
