The binding of a peptide to the antigen binding groove of an MHC class II protein complex.

The binding of a peptide to the antigen binding groove of an MHC class II protein complex.

Any process that activates or increases the frequency, rate, or extent of germinal center formation.

Any process that activates or increases the frequency, rate, or extent of a humoral immune response.

The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

An immune response mediated by immunoglobulins, whether cell-bound or in solution.

The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.

The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.

The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death.

Any process that activates or increases the frequency, rate or extent of T cell differentiation.

The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release.

The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release.

The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.

The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.

A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.

A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.

The external part of the cell wall and/or plasma membrane.

The external part of the cell wall and/or plasma membrane.

The lipid bilayer surrounding an endosome.

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen.

A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen.

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.