The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Immunoglobulins
".
FunFam 693: IgG receptor FcRn large subunit p51
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
IgG binding GO:0019864
Interacting selectively and non-covalently with an immunoglobulin of an IgG isotype.
|
3 | P55899 (/IDA) P55899 (/IDA) P55899 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | P13599 (/IPI) |
|
IgG receptor activity GO:0019770
Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
1 | P13599 (/TAS) |
|
IgG binding GO:0019864
Interacting selectively and non-covalently with an immunoglobulin of an IgG isotype.
|
1 | Q61559 (/ISO) |
|
Beta-2-microglobulin binding GO:0030881
Interacting selectively and non-covalently with beta-2-microglobulin.
|
1 | P13599 (/IDA) |
|
Beta-2-microglobulin binding GO:0030881
Interacting selectively and non-covalently with beta-2-microglobulin.
|
1 | Q61559 (/ISO) |
There are 2 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor GO:0002416
The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals.
|
3 | P55899 (/NAS) P55899 (/NAS) P55899 (/NAS) |
|
Humoral immune response GO:0006959
An immune response mediated through a body fluid.
|
1 | P13599 (/TAS) |
There are 0 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
