The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Immunoglobulins
".
FunFam 521: leukocyte surface antigen CD47
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | Q08722 (/IPI) Q61735 (/IPI) Q61735 (/IPI) |
|
Thrombospondin receptor activity GO:0070053
Combining with thrombospondin and transmitting the signal to initiate a change in cell activity.
|
2 | Q61735 (/ISO) Q61735 (/ISO) |
|
Protein binding involved in heterotypic cell-cell adhesion GO:0086080
Interacting selectively and non-covalently with any protein or protein complex contributing to the adhesion of two different types of cells.
|
2 | Q61735 (/ISO) Q61735 (/ISO) |
|
Cell-cell adhesion mediator activity GO:0098632
The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell.
|
2 | Q61735 (/ISO) Q61735 (/ISO) |
|
Thrombospondin receptor activity GO:0070053
Combining with thrombospondin and transmitting the signal to initiate a change in cell activity.
|
1 | Q08722 (/IPI) |
|
Protein binding involved in heterotypic cell-cell adhesion GO:0086080
Interacting selectively and non-covalently with any protein or protein complex contributing to the adhesion of two different types of cells.
|
1 | P97829 (/IPI) |
|
Protein binding involved in heterotypic cell-cell adhesion GO:0086080
Interacting selectively and non-covalently with any protein or protein complex contributing to the adhesion of two different types of cells.
|
1 | Q08722 (/ISS) |
|
Cell-cell adhesion mediator activity GO:0098632
The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell.
|
1 | Q08722 (/IPI) |
There are 48 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Opsonization GO:0008228
The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody.
|
2 | Q61735 (/IDA) Q61735 (/IDA) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
2 | Q61735 (/ISO) Q61735 (/ISO) |
|
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
|
2 | Q61735 (/IMP) Q61735 (/IMP) |
|
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
2 | Q61735 (/ISO) Q61735 (/ISO) |
|
Positive regulation of cell-cell adhesion GO:0022409
Any process that activates or increases the rate or extent of cell adhesion to another cell.
|
2 | Q61735 (/ISO) Q61735 (/ISO) |
|
Regulation of interferon-gamma production GO:0032649
Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
|
2 | Q61735 (/ISO) Q61735 (/ISO) |
|
Regulation of interleukin-10 production GO:0032653
Any process that modulates the frequency, rate, or extent of interleukin-10 production.
|
2 | Q61735 (/ISO) Q61735 (/ISO) |
|
Regulation of interleukin-12 production GO:0032655
Any process that modulates the frequency, rate, or extent of interleukin-12 production.
|
2 | Q61735 (/ISO) Q61735 (/ISO) |
|
Regulation of interleukin-6 production GO:0032675
Any process that modulates the frequency, rate, or extent of interleukin-6 production.
|
2 | Q61735 (/ISO) Q61735 (/ISO) |
|
Regulation of tumor necrosis factor production GO:0032680
Any process that modulates the frequency, rate, or extent of tumor necrosis factor production.
|
2 | Q61735 (/ISO) Q61735 (/ISO) |
|
Monocyte extravasation GO:0035696
The migration of a monocyte from the blood vessels into the surrounding tissue.
|
2 | Q61735 (/ISO) Q61735 (/ISO) |
|
Regulation of nitric oxide biosynthetic process GO:0045428
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
|
2 | Q61735 (/IDA) Q61735 (/IDA) |
|
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
|
2 | Q61735 (/IMP) Q61735 (/IMP) |
|
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
|
2 | Q61735 (/IDA) Q61735 (/IDA) |
|
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
|
2 | Q61735 (/ISO) Q61735 (/ISO) |
|
Positive regulation of T cell activation GO:0050870
Any process that activates or increases the frequency, rate or extent of T cell activation.
|
2 | Q61735 (/ISO) Q61735 (/ISO) |
|
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
|
2 | Q61735 (/ISO) Q61735 (/ISO) |
|
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
|
2 | Q61735 (/ISO) Q61735 (/ISO) |
|
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
|
2 | Q61735 (/ISO) Q61735 (/ISO) |
|
Cellular response to interleukin-12 GO:0071349
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus.
|
2 | Q61735 (/ISO) Q61735 (/ISO) |
|
Negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis GO:1905450
Any process that stops, prevents or reduces the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis.
|
2 | Q61735 (/ISO) Q61735 (/ISO) |
|
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q08722 (/TAS) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | Q08722 (/IDA) |
|
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
1 | P97829 (/IDA) |
|
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
1 | Q08722 (/ISS) |
|
Positive regulation of cell-cell adhesion GO:0022409
Any process that activates or increases the rate or extent of cell adhesion to another cell.
|
1 | Q08722 (/IDA) |
|
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
|
1 | Q08722 (/TAS) |
|
Regulation of interferon-gamma production GO:0032649
Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
|
1 | Q08722 (/IMP) |
|
Regulation of interleukin-10 production GO:0032653
Any process that modulates the frequency, rate, or extent of interleukin-10 production.
|
1 | Q08722 (/IMP) |
|
Regulation of interleukin-12 production GO:0032655
Any process that modulates the frequency, rate, or extent of interleukin-12 production.
|
1 | Q08722 (/IMP) |
|
Regulation of interleukin-6 production GO:0032675
Any process that modulates the frequency, rate, or extent of interleukin-6 production.
|
1 | Q08722 (/IMP) |
|
Regulation of tumor necrosis factor production GO:0032680
Any process that modulates the frequency, rate, or extent of tumor necrosis factor production.
|
1 | Q08722 (/IMP) |
|
Monocyte extravasation GO:0035696
The migration of a monocyte from the blood vessels into the surrounding tissue.
|
1 | P97829 (/IMP) |
|
Monocyte extravasation GO:0035696
The migration of a monocyte from the blood vessels into the surrounding tissue.
|
1 | Q08722 (/ISS) |
|
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
|
1 | Q08722 (/TAS) |
|
Regulation of nitric oxide biosynthetic process GO:0045428
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
|
1 | Q08722 (/ISS) |
|
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
|
1 | P97829 (/IMP) |
|
Positive regulation of T cell activation GO:0050870
Any process that activates or increases the frequency, rate or extent of T cell activation.
|
1 | Q08722 (/IDA) |
|
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
|
1 | Q08722 (/TAS) |
|
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
|
1 | P97829 (/IMP) |
|
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
|
1 | Q08722 (/ISS) |
|
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
|
1 | P97829 (/IMP) |
|
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
|
1 | Q08722 (/ISS) |
|
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
|
1 | P97829 (/IMP) |
|
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
|
1 | Q08722 (/ISS) |
|
Cellular response to interleukin-12 GO:0071349
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus.
|
1 | Q08722 (/IMP) |
|
Negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis GO:1905450
Any process that stops, prevents or reduces the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis.
|
1 | P97829 (/IMP) |
|
Negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis GO:1905450
Any process that stops, prevents or reduces the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis.
|
1 | Q08722 (/ISS) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | Q08722 (/TAS) Q61735 (/TAS) Q61735 (/TAS) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | Q61735 (/IDA) Q61735 (/IDA) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
2 | P97829 (/IDA) Q08722 (/IDA) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
2 | Q61735 (/ISO) Q61735 (/ISO) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
2 | Q61735 (/IDA) Q61735 (/IDA) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q08722 (/TAS) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | Q08722 (/ISS) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | Q08722 (/NAS) |
|
Specific granule membrane GO:0035579
The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
|
1 | Q08722 (/TAS) |
|
Tertiary granule membrane GO:0070821
The lipid bilayer surrounding a tertiary granule.
|
1 | Q08722 (/TAS) |
