The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 385: Neuroplastin a

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
13 P97300 (/IPI) Q6NZV3 (/IPI) Q9Y639 (/IPI) Q9Y639 (/IPI) Q9Y639 (/IPI) Q9Y639 (/IPI) Q9Y639 (/IPI) Q9Y639 (/IPI) Q9Y639 (/IPI) Q9Y639 (/IPI)
(3 more)
Type 1 fibroblast growth factor receptor binding GO:0005105
Interacting selectively and non-covalently with the type 1 fibroblast growth factor receptor (FGFR1).
12 P97300 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS)
(2 more)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
12 P97300 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS)
(2 more)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
1 P97546 (/IPI)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
1 P97546 (/IDA)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of cytokine production GO:0001818
Any process that stops, prevents, or reduces the rate of production of a cytokine.
12 P97546 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS)
(2 more)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
12 P97300 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS)
(2 more)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
12 P97300 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS)
(2 more)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
12 P97300 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS)
(2 more)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
12 P97300 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS)
(2 more)
Positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743
Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.
12 P97300 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS)
(2 more)
Positive regulation of long-term neuronal synaptic plasticity GO:0048170
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
12 P97300 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS)
(2 more)
Long-term synaptic potentiation GO:0060291
A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse.
12 P97300 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS)
(2 more)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
11 Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS)
(1 more)
Response to steroid hormone GO:0048545
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.
7 A4IGC1 (/IEP) Q08CP9 (/IEP) Q1JPX2 (/IEP) Q4V8T3 (/IEP) Q503N7 (/IEP) Q6DHD4 (/IEP) Q6P0R7 (/IEP)
Negative regulation of cytokine production GO:0001818
Any process that stops, prevents, or reduces the rate of production of a cytokine.
1 P97300 (/IMP)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
1 P97300 (/IMP)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
1 P97546 (/IDA)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
1 P97546 (/IDA)
Visual learning GO:0008542
Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.
1 P97546 (/IDA)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P97546 (/IDA)
Regulation of cell adhesion GO:0030155
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
1 P97546 (/TAS)
Positive regulation of long-term neuronal synaptic plasticity GO:0048170
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
1 P97546 (/IMP)
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
1 P97300 (/IMP)
Synapse organization GO:0050808
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
1 P97300 (/IMP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 P97546 (/IDA)
Trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission GO:0099557
Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse.
1 P97546 (/IDA)
Positive regulation of long-term synaptic potentiation GO:1900273
Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation.
1 P97546 (/IMP)
Regulation of receptor localization to synapse GO:1902683
Any process that modulates the frequency, rate or extent of receptor localization to synapse.
1 P97300 (/IMP)
Positive regulation of cellular protein localization GO:1903829
Any process that activates or increases the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
1 P97546 (/IMP)
Excitatory synapse assembly GO:1904861
The aggregation, arrangement and bonding together of a set of components to form an excitatory synapse.
1 P97300 (/IMP)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Immunological synapse GO:0001772
An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
12 P97546 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS)
(2 more)
Presynaptic membrane GO:0042734
A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
12 P97300 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS) Q9Y639 (/ISS)
(2 more)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
11 Q9Y639 (/HDA) Q9Y639 (/HDA) Q9Y639 (/HDA) Q9Y639 (/HDA) Q9Y639 (/HDA) Q9Y639 (/HDA) Q9Y639 (/HDA) Q9Y639 (/HDA) Q9Y639 (/HDA) Q9Y639 (/HDA)
(1 more)
Immunological synapse GO:0001772
An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
1 P97300 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P97546 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P97546 (/IDA)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 P97546 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P97546 (/TAS)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 P97546 (/IDA)
Presynaptic membrane GO:0042734
A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
1 P97546 (/IDA)
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
1 P97546 (/TAS)
Inhibitory synapse GO:0060077
A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell.
1 P97546 (/IDA)
Synaptic membrane GO:0097060
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
1 P97546 (/IDA)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
1 P97546 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P97546 (/EXP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P97546 (/IDA)
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
1 P97546 (/EXP)
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
1 P97546 (/IDA)
Integral component of presynaptic active zone membrane GO:0099059
The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P97546 (/EXP)
Integral component of presynaptic active zone membrane GO:0099059
The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P97546 (/IDA)
Integral component of postsynaptic density membrane GO:0099061
The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P97546 (/IDA)
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