The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 354: Pro-neuregulin-2, membrane-bound isoform

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Epidermal growth factor-activated receptor activity GO:0005006
Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
1 O35569 (/IDA)
Epidermal growth factor-activated receptor activity GO:0005006
Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
1 P56974 (/ISO)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 O14511 (/TAS)
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
1 O35569 (/IDA)
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
1 P56974 (/ISO)
ErbB-3 class receptor binding GO:0043125
Interacting selectively and non-covalently with the protein-tyrosine kinase receptor ErbB-3/HER3.
1 O35569 (/IDA)
ErbB-3 class receptor binding GO:0043125
Interacting selectively and non-covalently with the protein-tyrosine kinase receptor ErbB-3/HER3.
1 P56974 (/ISO)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Neural crest cell migration GO:0001755
The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
8 A0A0R4IBM0 (/IGI) A0A0R4IDP7 (/IGI) A0A0R4IPH3 (/IGI) A0A1B4Z255 (/IGI) B3DK99 (/IGI) B9VQK7 (/IGI) B9VQK8 (/IGI) B9VQK9 (/IGI)
Ventricular trabecula myocardium morphogenesis GO:0003222
The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized.
8 A0A0R4IBM0 (/IMP) A0A0R4IDP7 (/IMP) A0A0R4IPH3 (/IMP) A0A1B4Z255 (/IMP) B3DK99 (/IMP) B9VQK7 (/IMP) B9VQK8 (/IMP) B9VQK9 (/IMP)
Peripheral nervous system development GO:0007422
The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
8 A0A0R4IBM0 (/IMP) A0A0R4IDP7 (/IMP) A0A0R4IPH3 (/IMP) A0A1B4Z255 (/IMP) B3DK99 (/IMP) B9VQK7 (/IMP) B9VQK8 (/IMP) B9VQK9 (/IMP)
Schwann cell development GO:0014044
The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.
8 A0A0R4IBM0 (/IMP) A0A0R4IDP7 (/IMP) A0A0R4IPH3 (/IMP) A0A1B4Z255 (/IMP) B3DK99 (/IMP) B9VQK7 (/IMP) B9VQK8 (/IMP) B9VQK9 (/IMP)
Eurydendroid cell differentiation GO:0021755
The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature eurydendroid cell. Differentiation includes the processes involved in commitment of a neuroblast to a eurydendroid cell fate. A eurydendroid cell is an efferent neuron found in the cerebellar cortex of teleosts.
8 A0A0R4IBM0 (/IMP) A0A0R4IDP7 (/IMP) A0A0R4IPH3 (/IMP) A0A1B4Z255 (/IMP) B3DK99 (/IMP) B9VQK7 (/IMP) B9VQK8 (/IMP) B9VQK9 (/IMP)
Oligodendrocyte cell fate specification GO:0021778
The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.
8 A0A0R4IBM0 (/IMP) A0A0R4IDP7 (/IMP) A0A0R4IPH3 (/IMP) A0A1B4Z255 (/IMP) B3DK99 (/IMP) B9VQK7 (/IMP) B9VQK8 (/IMP) B9VQK9 (/IMP)
Fin regeneration GO:0031101
The regrowth of fin tissue following its loss or destruction.
8 A0A0R4IBM0 (/IMP) A0A0R4IDP7 (/IMP) A0A0R4IPH3 (/IMP) A0A1B4Z255 (/IMP) B3DK99 (/IMP) B9VQK7 (/IMP) B9VQK8 (/IMP) B9VQK9 (/IMP)
Schwann cell migration GO:0036135
The orderly movement of a Schwann cell from one site to another. A Schwann cell is a glial cell that ensheathes axons of neuron in the peripheral nervous system and is necessary for their maintainance and function.
8 A0A0R4IBM0 (/IMP) A0A0R4IDP7 (/IMP) A0A0R4IPH3 (/IMP) A0A1B4Z255 (/IMP) B3DK99 (/IMP) B9VQK7 (/IMP) B9VQK8 (/IMP) B9VQK9 (/IMP)
Enteric nervous system development GO:0048484
The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation.
8 A0A0R4IBM0 (/IMP) A0A0R4IDP7 (/IMP) A0A0R4IPH3 (/IMP) A0A1B4Z255 (/IMP) B3DK99 (/IMP) B9VQK7 (/IMP) B9VQK8 (/IMP) B9VQK9 (/IMP)
Generation of neurons GO:0048699
The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons.
8 A0A0R4IBM0 (/IMP) A0A0R4IDP7 (/IMP) A0A0R4IPH3 (/IMP) A0A1B4Z255 (/IMP) B3DK99 (/IMP) B9VQK7 (/IMP) B9VQK8 (/IMP) B9VQK9 (/IMP)
Cardiac neuron development GO:0060959
The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state.
8 A0A0R4IBM0 (/IMP) A0A0R4IDP7 (/IMP) A0A0R4IPH3 (/IMP) A0A1B4Z255 (/IMP) B3DK99 (/IMP) B9VQK7 (/IMP) B9VQK8 (/IMP) B9VQK9 (/IMP)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
1 O14511 (/TAS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 O14511 (/TAS)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 O35569 (/IDA)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 P56974 (/ISO)
ERBB2 signaling pathway GO:0038128
A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair.
1 O14511 (/TAS)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
1 O14511 (/TAS)
Regulation of synapse assembly GO:0051963
Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
1 O35569 (/IDA)
Regulation of synapse assembly GO:0051963
Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
1 O35569 (/IMP)
Regulation of synapse assembly GO:0051963
Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
1 P56974 (/ISO)
Regulation of synapse maturation GO:0090128
Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state.
1 O35569 (/IDA)
Regulation of synapse maturation GO:0090128
Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state.
1 O35569 (/IMP)
Regulation of synapse maturation GO:0090128
Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state.
1 P56974 (/ISO)
Regulation of cell motility GO:2000145
Any process that modulates the frequency, rate or extent of cell motility.
1 O14511 (/TAS)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 O14511 (/TAS)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 O35569 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 O35569 (/IMP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P56974 (/ISO)
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
1 O35569 (/IDA)
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
1 O35569 (/IMP)
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
1 P56974 (/ISO)
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