The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 344: Muscle M-line assembly protein unc-89

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 O01761 (/IPI) O01761 (/IPI) O01761 (/IPI) O01761 (/IPI) O01761 (/IPI) O01761 (/IPI) Q9I7U4 (/IPI)
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
6 O01761 (/IDA) O01761 (/IDA) O01761 (/IDA) O01761 (/IDA) O01761 (/IDA) O01761 (/IDA)
Rho GTPase binding GO:0017048
Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.
6 O01761 (/IPI) O01761 (/IPI) O01761 (/IPI) O01761 (/IPI) O01761 (/IPI) O01761 (/IPI)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
6 O01761 (/IPI) O01761 (/IPI) O01761 (/IPI) O01761 (/IPI) O01761 (/IPI) O01761 (/IPI)
MATH domain binding GO:0090736
Interacting selectively and non-covalently with a meprin and TRAF homology (MATH) domain.
6 O01761 (/IPI) O01761 (/IPI) O01761 (/IPI) O01761 (/IPI) O01761 (/IPI) O01761 (/IPI)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 Q9I7U4 (/IDA)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 Q9I7U4 (/IMP)
Structural constituent of muscle GO:0008307
The action of a molecule that contributes to the structural integrity of a muscle fiber.
1 Q9I7U4 (/IMP)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
6 O01761 (/IMP) O01761 (/IMP) O01761 (/IMP) O01761 (/IMP) O01761 (/IMP) O01761 (/IMP)
Skeletal muscle myosin thick filament assembly GO:0030241
The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle.
6 O01761 (/IMP) O01761 (/IMP) O01761 (/IMP) O01761 (/IMP) O01761 (/IMP) O01761 (/IMP)
Myosin filament assembly GO:0031034
The aggregation, arrangement and bonding together of a filament composed of myosin molecules.
6 O01761 (/IMP) O01761 (/IMP) O01761 (/IMP) O01761 (/IMP) O01761 (/IMP) O01761 (/IMP)
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
6 O01761 (/IDA) O01761 (/IDA) O01761 (/IDA) O01761 (/IDA) O01761 (/IDA) O01761 (/IDA)
Positive regulation of locomotion GO:0040017
Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
6 O01761 (/IGI) O01761 (/IGI) O01761 (/IGI) O01761 (/IGI) O01761 (/IGI) O01761 (/IGI)
Positive regulation of striated muscle contraction GO:0045989
Any process that activates or increases the frequency, rate or extent of striated muscle contraction.
6 O01761 (/IGI) O01761 (/IGI) O01761 (/IGI) O01761 (/IGI) O01761 (/IGI) O01761 (/IGI)
Striated muscle myosin thick filament assembly GO:0071688
The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in striated muscle.
6 O01761 (/IMP) O01761 (/IMP) O01761 (/IMP) O01761 (/IMP) O01761 (/IMP) O01761 (/IMP)
Pharyngeal gland morphogenesis GO:1905905
The developmental process by which a pharyngeal gland is generated and organized.
6 O01761 (/IMP) O01761 (/IMP) O01761 (/IMP) O01761 (/IMP) O01761 (/IMP) O01761 (/IMP)
Sister chromatid cohesion GO:0007062
The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.
1 Q9I7U4 (/IMP)
Mitotic chromosome condensation GO:0007076
The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
1 Q9I7U4 (/IMP)
Mesoderm development GO:0007498
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
1 Q9I7U4 (/IEP)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
1 Q9I7U4 (/TAS)
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
1 Q9I7U4 (/IMP)
Myoblast fusion GO:0007520
A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
1 Q9I7U4 (/IMP)
Visceral muscle development GO:0007522
The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure.
1 Q9I7U4 (/IEP)
Somatic muscle development GO:0007525
The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle.
1 Q9I7U4 (/IEP)
Muscle attachment GO:0016203
The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).
1 Q9I7U4 (/IMP)
Regulation of hemocyte proliferation GO:0035206
Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster.
1 Q9I7U4 (/IMP)
Locomotion GO:0040011
Self-propelled movement of a cell or organism from one location to another.
1 Q9I7U4 (/IMP)
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 Q9I7U4 (/IDA)
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 Q9I7U4 (/IGI)
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 Q9I7U4 (/IMP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
M band GO:0031430
The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.
6 O01761 (/IDA) O01761 (/IDA) O01761 (/IDA) O01761 (/IDA) O01761 (/IDA) O01761 (/IDA)
A band GO:0031672
The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.
6 O01761 (/IDA) O01761 (/IDA) O01761 (/IDA) O01761 (/IDA) O01761 (/IDA) O01761 (/IDA)
Condensed nuclear chromosome GO:0000794
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
1 Q9I7U4 (/IDA)
Striated muscle myosin thick filament GO:0005863
Bipolar filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils.
1 Q9I7U4 (/IDA)
Sarcomere GO:0030017
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
1 Q9I7U4 (/IDA)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
1 Q9I7U4 (/HDA)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
1 Q9I7U4 (/IDA)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
1 Q9I7U4 (/IMP)
I band GO:0031674
A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.
1 Q9I7U4 (/IDA)
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