The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1723: Interference hedgehog

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
13 B3MKS0 (/ISS) B3N666 (/ISS) B4GKZ8 (/ISS) B4HY03 (/ISS) B4JEF2 (/ISS) B4KJW1 (/ISS) B4KJW1 (/ISS) B4LRN7 (/ISS) B4LRN7 (/ISS) B4N072 (/ISS)
(3 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
13 B3MKS0 (/ISS) B3N666 (/ISS) B4GKZ8 (/ISS) B4HY03 (/ISS) B4JEF2 (/ISS) B4KJW1 (/ISS) B4KJW1 (/ISS) B4LRN7 (/ISS) B4LRN7 (/ISS) B4N072 (/ISS)
(3 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 A8JUV7 (/IPI) Q9VM64 (/IPI)
Coreceptor activity GO:0015026
Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.
2 A8JUV7 (/IGI) Q9VM64 (/IGI)
Hedgehog family protein binding GO:0097108
Interacting selectively and non-covalently with a member of the hedgehog protein family, signaling proteins involved in development.
2 A8JUV7 (/IDA) Q9VM64 (/IDA)
Patched binding GO:0005113
Interacting selectively and non-covalently with the patched (ptc) protein, a receptor for hedgehog proteins.
1 Q9VM64 (/IPI)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
1 Q9VM64 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q9VM64 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q9VM64 (/IDA)
Hedgehog family protein binding GO:0097108
Interacting selectively and non-covalently with a member of the hedgehog protein family, signaling proteins involved in development.
1 Q9VM64 (/IPI)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Smoothened signaling pathway GO:0007224
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
13 B3MKS0 (/ISS) B3N666 (/ISS) B4GKZ8 (/ISS) B4HY03 (/ISS) B4JEF2 (/ISS) B4KJW1 (/ISS) B4KJW1 (/ISS) B4LRN7 (/ISS) B4LRN7 (/ISS) B4N072 (/ISS)
(3 more)
Smoothened signaling pathway GO:0007224
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
2 A8JUV7 (/IGI) Q9VM64 (/IGI)
Smoothened signaling pathway GO:0007224
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
2 A8JUV7 (/IMP) Q9VM64 (/IMP)
Cuticle pattern formation GO:0035017
The regionalization process that gives rise to the patterns of cell differentiation in the cuticle.
2 A8JUV7 (/IGI) Q9VM64 (/IGI)
Wing disc pattern formation GO:0035222
The process giving rise to the pattern of cell differentiation in the wing imaginal disc.
2 A8JUV7 (/IGI) Q9VM64 (/IGI)
Compound eye development GO:0048749
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.
2 A8JUV7 (/IGI) Q9VM64 (/IGI)
Maintenance of protein location in extracellular region GO:0071694
Any process in which a protein is maintained in a specific location within the extracellular region and is prevented from moving elsewhere.
2 A8JUV7 (/IGI) Q9VM64 (/IGI)
Compound eye photoreceptor cell differentiation GO:0001751
The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell.
1 A8JUV7 (/IGI)
Smoothened signaling pathway GO:0007224
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
1 Q9VM64 (/IDA)
Segment specification GO:0007379
The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes.
1 Q9VM64 (/IMP)
Cuticle pattern formation GO:0035017
The regionalization process that gives rise to the patterns of cell differentiation in the cuticle.
1 Q9VM64 (/IMP)
Wing disc pattern formation GO:0035222
The process giving rise to the pattern of cell differentiation in the wing imaginal disc.
1 Q9VM64 (/IMP)
Maintenance of protein location in extracellular region GO:0071694
Any process in which a protein is maintained in a specific location within the extracellular region and is prevented from moving elsewhere.
1 A8JUV7 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
13 B3MKS0 (/ISS) B3N666 (/ISS) B4GKZ8 (/ISS) B4HY03 (/ISS) B4JEF2 (/ISS) B4KJW1 (/ISS) B4KJW1 (/ISS) B4LRN7 (/ISS) B4LRN7 (/ISS) B4N072 (/ISS)
(3 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q9VM64 (/TAS) Q9W4Y6 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 A8JUV7 (/IDA) Q9VM64 (/IDA)
Cytoneme GO:0035230
A long, thin, polarized cell projection that contains actin and can extend for distances many times the diameter of the cell. Cytonemes represent extensions of cell cytoplasm and typically have a diameter of approximately 0.2um.
2 A8JUV7 (/IDA) Q9VM64 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9VM64 (/IDA)
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