The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Immunoglobulins
".
FunFam 1516: Signaling lymphocytic activation molecule
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | Q13291 (/IPI) Q9QUM4 (/IPI) Q9QUM4 (/IPI) |
|
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
|
2 | Q9QUM4 (/IDA) Q9QUM4 (/IDA) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
2 | Q9QUM4 (/IDA) Q9QUM4 (/IDA) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
2 | Q9QUM4 (/ISO) Q9QUM4 (/ISO) |
|
Antigen binding GO:0003823
Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen.
|
1 | Q13291 (/TAS) |
|
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
|
1 | Q13291 (/TAS) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q13291 (/IPI) |
There are 27 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Natural killer cell differentiation GO:0001779
The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.
|
2 | Q9QUM4 (/IMP) Q9QUM4 (/IMP) |
|
Natural killer cell proliferation GO:0001787
The expansion of a natural killer cell population by cell division.
|
2 | Q9QUM4 (/IMP) Q9QUM4 (/IMP) |
|
Leukocyte chemotaxis involved in inflammatory response GO:0002232
The movement of an immune cell in response to an external stimulus contributing to an inflammatory response.
|
2 | Q9QUM4 (/IMP) Q9QUM4 (/IMP) |
|
Myeloid dendritic cell activation involved in immune response GO:0002277
The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
|
2 | Q9QUM4 (/ISO) Q9QUM4 (/ISO) |
|
Negative regulation of T cell cytokine production GO:0002725
Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.
|
2 | Q9QUM4 (/IDA) Q9QUM4 (/IDA) |
|
Positive regulation of macrophage chemotaxis GO:0010759
Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.
|
2 | Q9QUM4 (/IMP) Q9QUM4 (/IMP) |
|
Regulation of vesicle fusion GO:0031338
Any process that modulates the frequency, rate or extent of vesicle fusion.
|
2 | Q9QUM4 (/IMP) Q9QUM4 (/IMP) |
|
Negative regulation of interleukin-12 production GO:0032695
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production.
|
2 | Q9QUM4 (/ISO) Q9QUM4 (/ISO) |
|
Negative regulation of interleukin-6 production GO:0032715
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.
|
2 | Q9QUM4 (/ISO) Q9QUM4 (/ISO) |
|
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
|
2 | Q9QUM4 (/ISO) Q9QUM4 (/ISO) |
|
T-helper 1 cell cytokine production GO:0035744
Any process that contributes to cytokine production by a T-helper 1 cell.
|
2 | Q9QUM4 (/IDA) Q9QUM4 (/IDA) |
|
Positive regulation of activated T cell proliferation GO:0042104
Any process that activates or increases the rate or extent of activated T cell proliferation.
|
2 | Q9QUM4 (/IDA) Q9QUM4 (/IDA) |
|
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
2 | Q9QUM4 (/ISO) Q9QUM4 (/ISO) |
|
Regulation of catalytic activity GO:0050790
Any process that modulates the activity of an enzyme.
|
2 | Q9QUM4 (/IMP) Q9QUM4 (/IMP) |
|
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
2 | Q9QUM4 (/ISO) Q9QUM4 (/ISO) |
|
Negative regulation of interferon-gamma secretion GO:1902714
Any process that stops, prevents or reduces the frequency, rate or extent of interferon-gamma secretion.
|
2 | Q9QUM4 (/IDA) Q9QUM4 (/IDA) |
|
Positive regulation of interferon-gamma secretion GO:1902715
Any process that activates or increases the frequency, rate or extent of interferon-gamma secretion.
|
2 | Q9QUM4 (/IDA) Q9QUM4 (/IDA) |
|
Negative regulation of CD40 signaling pathway GO:2000349
Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the CD40 signaling pathway.
|
2 | Q9QUM4 (/ISO) Q9QUM4 (/ISO) |
|
Positive regulation of dendritic cell chemotaxis GO:2000510
Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis.
|
2 | Q9QUM4 (/IMP) Q9QUM4 (/IMP) |
|
Myeloid dendritic cell activation involved in immune response GO:0002277
The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
|
1 | Q13291 (/IDA) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | Q13291 (/TAS) |
|
Negative regulation of interleukin-12 production GO:0032695
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production.
|
1 | Q13291 (/IDA) |
|
Negative regulation of interleukin-6 production GO:0032715
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.
|
1 | Q13291 (/IDA) |
|
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
|
1 | Q13291 (/IDA) |
|
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
1 | Q13291 (/IDA) |
|
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | Q13291 (/IDA) |
|
Negative regulation of CD40 signaling pathway GO:2000349
Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the CD40 signaling pathway.
|
1 | Q13291 (/IDA) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
2 | Q9QUM4 (/IDA) Q9QUM4 (/IDA) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
2 | Q9QUM4 (/IDA) Q9QUM4 (/IDA) |
|
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
|
2 | Q9QUM4 (/IDA) Q9QUM4 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q13291 (/HDA) |
