The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1299: Programmed cell death 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 Q4QTK1 (/IPI) Q4QTK1 (/IPI) Q9EP73 (/IPI) Q9EP73 (/IPI) Q9NZQ7 (/IPI)

There are 39 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of activated T cell proliferation GO:0046007
Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation.
3 Q4QTK1 (/IMP) Q4QTK1 (/IMP) Q9NZQ7 (/IMP)
Positive regulation of tolerance induction to tumor cell GO:0002845
Any process that activates or increases the frequency, rate, or extent of tolerance induction to tumor cell.
2 Q9EP73 (/ISO) Q9EP73 (/ISO)
Positive regulation of tolerance induction to tumor cell GO:0002845
Any process that activates or increases the frequency, rate, or extent of tolerance induction to tumor cell.
2 Q9EP73 (/ISS) Q9EP73 (/ISS)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
2 Q9EP73 (/ISO) Q9EP73 (/ISO)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2 Q9EP73 (/ISO) Q9EP73 (/ISO)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2 Q9EP73 (/ISO) Q9EP73 (/ISO)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
2 Q9EP73 (/ISO) Q9EP73 (/ISO)
T cell costimulation GO:0031295
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.
2 Q9EP73 (/ISO) Q9EP73 (/ISO)
Negative regulation of interferon-gamma production GO:0032689
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
2 Q9EP73 (/ISO) Q9EP73 (/ISO)
Negative regulation of interleukin-10 production GO:0032693
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production.
2 Q9EP73 (/ISO) Q9EP73 (/ISO)
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
2 Q9EP73 (/ISO) Q9EP73 (/ISO)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
2 Q9EP73 (/ISO) Q9EP73 (/ISO)
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
2 Q9EP73 (/IDA) Q9EP73 (/IDA)
Negative regulation of activated T cell proliferation GO:0046007
Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation.
2 Q9EP73 (/ISO) Q9EP73 (/ISO)
Positive regulation of T cell apoptotic process GO:0070234
Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process.
2 Q4QTK1 (/IMP) Q4QTK1 (/IMP)
Toxin transport GO:1901998
The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q9EP73 (/IMP) Q9EP73 (/IMP)
Negative regulation of tumor necrosis factor superfamily cytokine production GO:1903556
Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor superfamily cytokine production.
2 Q9EP73 (/ISO) Q9EP73 (/ISO)
Positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process GO:1905404
Any process that activates or increases the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process.
2 Q9EP73 (/ISO) Q9EP73 (/ISO)
Negative regulation of CD4-positive, alpha-beta T cell proliferation GO:2000562
Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation.
2 Q9EP73 (/ISO) Q9EP73 (/ISO)
Positive regulation of interleukin-10 secretion GO:2001181
Any process that activates or increases the frequency, rate or extent of interleukin-10 secretion.
2 Q9EP73 (/ISO) Q9EP73 (/ISO)
Negative regulation of CD8-positive, alpha-beta T cell activation GO:2001186
Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell activation.
2 Q9EP73 (/ISO) Q9EP73 (/ISO)
Negative regulation of CD8-positive, alpha-beta T cell activation GO:2001186
Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell activation.
2 Q9EP73 (/ISS) Q9EP73 (/ISS)
Positive regulation of tolerance induction to tumor cell GO:0002845
Any process that activates or increases the frequency, rate, or extent of tolerance induction to tumor cell.
1 Q9NZQ7 (/IMP)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
1 Q9NZQ7 (/IDA)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 Q9NZQ7 (/IDA)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 Q9NZQ7 (/IDA)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 D4AE25 (/IMP)
T cell costimulation GO:0031295
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.
1 Q9NZQ7 (/IDA)
T cell costimulation GO:0031295
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.
1 Q9NZQ7 (/TAS)
Negative regulation of interferon-gamma production GO:0032689
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
1 Q9NZQ7 (/IMP)
Negative regulation of interleukin-10 production GO:0032693
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production.
1 Q9NZQ7 (/IMP)
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
1 Q9NZQ7 (/IDA)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
1 D4AE25 (/IMP)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
1 Q9NZQ7 (/TAS)
Negative regulation of tumor necrosis factor superfamily cytokine production GO:1903556
Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor superfamily cytokine production.
1 Q9NZQ7 (/IMP)
Positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process GO:1905404
Any process that activates or increases the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process.
1 Q9NZQ7 (/IDA)
Negative regulation of CD4-positive, alpha-beta T cell proliferation GO:2000562
Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation.
1 Q9NZQ7 (/IDA)
Positive regulation of interleukin-10 secretion GO:2001181
Any process that activates or increases the frequency, rate or extent of interleukin-10 secretion.
1 Q9NZQ7 (/IDA)
Negative regulation of CD8-positive, alpha-beta T cell activation GO:2001186
Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell activation.
1 Q9NZQ7 (/IMP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q9EP73 (/ISO) Q9EP73 (/ISO)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
2 Q9EP73 (/IDA) Q9EP73 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 Q9EP73 (/ISO) Q9EP73 (/ISO)
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
2 Q9EP73 (/ISO) Q9EP73 (/ISO)
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
2 Q9EP73 (/ISS) Q9EP73 (/ISS)
Recycling endosome membrane GO:0055038
The lipid bilayer surrounding a recycling endosome.
2 Q9EP73 (/ISO) Q9EP73 (/ISO)
Recycling endosome membrane GO:0055038
The lipid bilayer surrounding a recycling endosome.
2 Q9EP73 (/ISS) Q9EP73 (/ISS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 Q9EP73 (/ISO) Q9EP73 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9NZQ7 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9NZQ7 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 D4AE25 (/IDA)
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
1 Q9NZQ7 (/IDA)
Recycling endosome membrane GO:0055038
The lipid bilayer surrounding a recycling endosome.
1 Q9NZQ7 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q9NZQ7 (/IDA)
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