The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 107: Myosin, light chain kinase a

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Structural constituent of muscle GO:0008307
The action of a molecule that contributes to the structural integrity of a muscle fiber.
59 A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP)
(49 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 A8DYP0 (/IPI) O01761 (/IPI) O01761 (/IPI) O01761 (/IPI) O01761 (/IPI)
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
4 O01761 (/IDA) O01761 (/IDA) O01761 (/IDA) O01761 (/IDA)
Rho GTPase binding GO:0017048
Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.
4 O01761 (/IPI) O01761 (/IPI) O01761 (/IPI) O01761 (/IPI)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
4 O01761 (/IPI) O01761 (/IPI) O01761 (/IPI) O01761 (/IPI)
MATH domain binding GO:0090736
Interacting selectively and non-covalently with a meprin and TRAF homology (MATH) domain.
4 O01761 (/IPI) O01761 (/IPI) O01761 (/IPI) O01761 (/IPI)
Tropomyosin binding GO:0005523
Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle.
1 A8DYP0 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 A8DYP0 (/IPI)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
86 A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A5X6X5 (/IGI) A5X6X5 (/IGI)
(76 more)
Myofibril assembly GO:0030239
Formation of myofibrils, the repeating units of striated muscle.
86 A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A5X6X5 (/IGI) A5X6X5 (/IGI)
(76 more)
Sarcomerogenesis GO:0048769
The process in which sarcomeres are added in series within a fiber.
86 A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A5X6X5 (/IGI) A5X6X5 (/IGI)
(76 more)
Sarcomerogenesis GO:0048769
The process in which sarcomeres are added in series within a fiber.
86 A0A2R8PZT6 (/IMP) A0A2R8PZT6 (/IMP) A0A2R8PZT6 (/IMP) A0A2R8PZT6 (/IMP) A0A2R8PZT6 (/IMP) A0A2R8PZT6 (/IMP) A0A2R8PZT6 (/IMP) A0A2R8PZT6 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP)
(76 more)
Striated muscle myosin thick filament assembly GO:0071688
The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in striated muscle.
86 A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A0A2R8PZT6 (/IGI) A5X6X5 (/IGI) A5X6X5 (/IGI)
(76 more)
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
60 A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP)
(50 more)
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
59 A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP)
(49 more)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
59 A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP)
(49 more)
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
59 A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP)
(49 more)
Cardiac muscle tissue development GO:0048738
The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.
59 A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP)
(49 more)
Heart contraction GO:0060047
The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.
59 A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP) A5X6X5 (/IMP)
(49 more)
Skeletal myofibril assembly GO:0014866
The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells.
27 A0A2R8PZT6 (/IMP) A0A2R8PZT6 (/IMP) A0A2R8PZT6 (/IMP) A0A2R8PZT6 (/IMP) A0A2R8PZT6 (/IMP) A0A2R8PZT6 (/IMP) A0A2R8PZT6 (/IMP) A0A2R8PZT6 (/IMP) A5X6X6 (/IMP) A5X6X6 (/IMP)
(17 more)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
4 O01761 (/IMP) O01761 (/IMP) O01761 (/IMP) O01761 (/IMP)
Skeletal muscle myosin thick filament assembly GO:0030241
The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle.
4 O01761 (/IMP) O01761 (/IMP) O01761 (/IMP) O01761 (/IMP)
Myosin filament assembly GO:0031034
The aggregation, arrangement and bonding together of a filament composed of myosin molecules.
4 O01761 (/IMP) O01761 (/IMP) O01761 (/IMP) O01761 (/IMP)
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
4 O01761 (/IDA) O01761 (/IDA) O01761 (/IDA) O01761 (/IDA)
Positive regulation of locomotion GO:0040017
Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
4 O01761 (/IGI) O01761 (/IGI) O01761 (/IGI) O01761 (/IGI)
Positive regulation of striated muscle contraction GO:0045989
Any process that activates or increases the frequency, rate or extent of striated muscle contraction.
4 O01761 (/IGI) O01761 (/IGI) O01761 (/IGI) O01761 (/IGI)
Striated muscle myosin thick filament assembly GO:0071688
The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in striated muscle.
4 O01761 (/IMP) O01761 (/IMP) O01761 (/IMP) O01761 (/IMP)
Pharyngeal gland morphogenesis GO:1905905
The developmental process by which a pharyngeal gland is generated and organized.
4 O01761 (/IMP) O01761 (/IMP) O01761 (/IMP) O01761 (/IMP)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
3 A8C985 (/IMP) B3DKN5 (/IMP) F1R221 (/IMP)
Regulation of cell motility GO:2000145
Any process that modulates the frequency, rate or extent of cell motility.
3 A8C985 (/IGI) B3DKN5 (/IGI) F1R221 (/IGI)
Adult somatic muscle development GO:0007527
The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure.
1 A8DYP0 (/IMP)
Protein localization to M-band GO:0036309
Any process in which a protein is transported to, and/or maintained in, the M band. The M band is the midline of aligned thick filaments in a sarcomere.
1 A8DYP0 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
M band GO:0031430
The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.
5 A8DYP0 (/IDA) O01761 (/IDA) O01761 (/IDA) O01761 (/IDA) O01761 (/IDA)
A band GO:0031672
The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.
4 O01761 (/IDA) O01761 (/IDA) O01761 (/IDA) O01761 (/IDA)
M band GO:0031430
The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.
1 A8DYP0 (/HDA)
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