The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Immunoglobulins
".
FunFam 1014: vascular endothelial growth factor receptor 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 19 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Vascular endothelial growth factor-activated receptor activity GO:0005021
Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity.
|
3 | P17948 (/IDA) P17948 (/IDA) P35969 (/IDA) |
Vascular endothelial growth factor-activated receptor activity GO:0005021
Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity.
|
3 | P17948 (/IMP) P17948 (/IMP) P53767 (/IMP) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | P17948 (/IPI) P17948 (/IPI) P35969 (/IPI) |
Growth factor binding GO:0019838
Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
|
3 | P17948 (/IPI) P17948 (/IPI) P53767 (/IPI) |
Transmembrane receptor protein tyrosine kinase activity GO:0004714
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
|
2 | P17948 (/TAS) P17948 (/TAS) |
Vascular endothelial growth factor-activated receptor activity GO:0005021
Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity.
|
2 | P17948 (/TAS) P17948 (/TAS) |
VEGF-A-activated receptor activity GO:0036326
Combining with vascular endothelial growth factor A (VEGF-A) and transmitting the signal across the plasma membrane to initiate a change in cell activity.
|
2 | P17948 (/IDA) P17948 (/IDA) |
VEGF-B-activated receptor activity GO:0036327
Combining with vascular endothelial growth factor B (VEGF-B) and transmitting the signal across the plasma membrane to initiate a change in cell activity.
|
2 | P17948 (/IDA) P17948 (/IDA) |
Placental growth factor-activated receptor activity GO:0036332
Combining with placental growth factor (PlGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity.
|
2 | P17948 (/IDA) P17948 (/IDA) |
Transmembrane receptor protein tyrosine kinase activity GO:0004714
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
|
1 | P53767 (/IDA) |
Showing 1 to 10 of 19 entries
There are 77 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
|
6 | A4QNT7 (/IMP) B3DKP1 (/IMP) F1QBD0 (/IMP) P35969 (/IMP) Q4JDD5 (/IMP) Q5GIT3 (/IMP) |
Sprouting angiogenesis GO:0002040
The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.
|
6 | A4QNT7 (/IMP) B3DKP1 (/IMP) F1QBD0 (/IMP) P35969 (/IMP) Q4JDD5 (/IMP) Q5GIT3 (/IMP) |
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
|
5 | A4QNT7 (/IGI) B3DKP1 (/IGI) F1QBD0 (/IGI) Q4JDD5 (/IGI) Q5GIT3 (/IGI) |
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
|
5 | A4QNT7 (/IMP) B3DKP1 (/IMP) F1QBD0 (/IMP) Q4JDD5 (/IMP) Q5GIT3 (/IMP) |
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
|
5 | A4QNT7 (/IMP) B3DKP1 (/IMP) F1QBD0 (/IMP) Q4JDD5 (/IMP) Q5GIT3 (/IMP) |
Sprouting angiogenesis GO:0002040
The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.
|
5 | A4QNT7 (/IGI) B3DKP1 (/IGI) F1QBD0 (/IGI) Q4JDD5 (/IGI) Q5GIT3 (/IGI) |
Regulation of heart contraction GO:0008016
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.
|
5 | A4QNT7 (/IMP) B3DKP1 (/IMP) F1QBD0 (/IMP) Q4JDD5 (/IMP) Q5GIT3 (/IMP) |
Venous blood vessel development GO:0060841
The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed.
|
5 | A4QNT7 (/IMP) B3DKP1 (/IMP) F1QBD0 (/IMP) Q4JDD5 (/IMP) Q5GIT3 (/IMP) |
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
3 | P17948 (/IMP) P17948 (/IMP) P35969 (/IMP) |
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
3 | P17948 (/IMP) P17948 (/IMP) P35969 (/IMP) |
Showing 1 to 10 of 77 entries
There are 15 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | L7RSL3 (/IDA) L7RSL3 (/IDA) P17948 (/IDA) P17948 (/IDA) P53767 (/IDA) |
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
4 | L7RSL3 (/IDA) L7RSL3 (/IDA) P17948 (/IDA) P17948 (/IDA) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
2 | P35969 (/IDA) P53767 (/IDA) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
2 | P17948 (/TAS) P17948 (/TAS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | P17948 (/TAS) P17948 (/TAS) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | P17948 (/IDA) P17948 (/IDA) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | P35969 (/ISS) P53767 (/ISS) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | P17948 (/TAS) P17948 (/TAS) |
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
2 | P17948 (/HDA) P17948 (/HDA) |
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
2 | P17948 (/IDA) P17948 (/IDA) |
Showing 1 to 10 of 15 entries