The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: TNF receptor-associated factor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 A8DYU9 (/IPI) Q9BUZ4 (/IPI) Q9BUZ4 (/IPI) Q9BUZ4 (/IPI) Q9UAC5 (/IPI) Q9XYR0 (/IPI) Q9XYR0 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
3 Q9BUZ4 (/TAS) Q9BUZ4 (/TAS) Q9BUZ4 (/TAS)
Tumor necrosis factor receptor binding GO:0005164
Interacting selectively and non-covalently with the tumor necrosis factor receptor.
3 Q9BUZ4 (/IPI) Q9BUZ4 (/IPI) Q9BUZ4 (/IPI)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
3 Q9BUZ4 (/IPI) Q9BUZ4 (/IPI) Q9BUZ4 (/IPI)
Thioesterase binding GO:0031996
Interacting selectively and non-covalently with any thioesterase enzyme.
3 Q9BUZ4 (/IPI) Q9BUZ4 (/IPI) Q9BUZ4 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 Q9BUZ4 (/IPI) Q9BUZ4 (/IPI) Q9BUZ4 (/IPI)
WW domain binding GO:0050699
Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.
3 Q9BUZ4 (/IPI) Q9BUZ4 (/IPI) Q9BUZ4 (/IPI)
Tumor necrosis factor receptor binding GO:0005164
Interacting selectively and non-covalently with the tumor necrosis factor receptor.
1 Q61382 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 Q61382 (/IPI)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 Q61382 (/ISO)
Thioesterase binding GO:0031996
Interacting selectively and non-covalently with any thioesterase enzyme.
1 Q61382 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q61382 (/ISO)
WW domain binding GO:0050699
Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.
1 Q61382 (/ISO)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Eye development GO:0001654
The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
4 A8DYU9 (/IMP) Q9UAC5 (/IMP) Q9XYR0 (/IMP) Q9XYR0 (/IMP)
Apical constriction involved in gastrulation GO:0003384
The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell, contributing to the process of gastrulation.
4 A8DYU9 (/IMP) Q9UAC5 (/IMP) Q9XYR0 (/IMP) Q9XYR0 (/IMP)
Ventral furrow formation GO:0007370
Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation.
4 A8DYU9 (/IMP) Q9UAC5 (/IMP) Q9XYR0 (/IMP) Q9XYR0 (/IMP)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
4 A8DYU9 (/TAS) Q9UAC5 (/TAS) Q9XYR0 (/TAS) Q9XYR0 (/TAS)
Adherens junction organization GO:0034332
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
4 A8DYU9 (/IMP) Q9UAC5 (/IMP) Q9XYR0 (/IMP) Q9XYR0 (/IMP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
4 A8DYU9 (/IMP) Q9UAC5 (/IMP) Q9XYR0 (/IMP) Q9XYR0 (/IMP)
Asymmetric protein localization involved in cell fate determination GO:0045167
Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types.
4 A8DYU9 (/IMP) Q9UAC5 (/IMP) Q9XYR0 (/IMP) Q9XYR0 (/IMP)
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
4 A8DYU9 (/IGI) Q9UAC5 (/IGI) Q9XYR0 (/IGI) Q9XYR0 (/IGI)
Imaginal disc fusion, thorax closure GO:0046529
The joining of the parts of the wing imaginal discs, giving rise to the adult thorax.
4 A8DYU9 (/IGI) Q9UAC5 (/IGI) Q9XYR0 (/IGI) Q9XYR0 (/IGI)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
4 A8DYU9 (/IMP) Q9UAC5 (/IMP) Q9XYR0 (/IMP) Q9XYR0 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
3 Q9BUZ4 (/TAS) Q9BUZ4 (/TAS) Q9BUZ4 (/TAS)
Positive regulation of protein kinase activity GO:0045860
Any process that activates or increases the frequency, rate or extent of protein kinase activity.
3 Q9BUZ4 (/IDA) Q9BUZ4 (/IDA) Q9BUZ4 (/IDA)
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
3 Q9BUZ4 (/IDA) Q9BUZ4 (/IDA) Q9BUZ4 (/IDA)
Positive regulation of protein homodimerization activity GO:0090073
Any process that increases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.
3 Q9BUZ4 (/IDA) Q9BUZ4 (/IDA) Q9BUZ4 (/IDA)
Respiratory gaseous exchange by respiratory system GO:0007585
The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.
1 Q61382 (/IMP)
Respiratory tube development GO:0030323
The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.
1 Q61382 (/IMP)
Positive regulation of protein kinase activity GO:0045860
Any process that activates or increases the frequency, rate or extent of protein kinase activity.
1 Q61382 (/ISO)
Positive regulation of protein kinase activity GO:0045860
Any process that activates or increases the frequency, rate or extent of protein kinase activity.
1 Q61382 (/ISS)
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
1 Q61382 (/ISO)
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
1 Q61382 (/ISS)
Positive regulation of protein homodimerization activity GO:0090073
Any process that increases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.
1 Q61382 (/ISO)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 A8DYU9 (/IDA) Q9BUZ4 (/IDA) Q9BUZ4 (/IDA) Q9BUZ4 (/IDA) Q9UAC5 (/IDA) Q9XYR0 (/IDA) Q9XYR0 (/IDA)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
4 A8DYU9 (/IDA) Q9UAC5 (/IDA) Q9XYR0 (/IDA) Q9XYR0 (/IDA)
Apical cortex GO:0045179
The region that lies just beneath the plasma membrane on the apical edge of a cell.
4 A8DYU9 (/IDA) Q9UAC5 (/IDA) Q9XYR0 (/IDA) Q9XYR0 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q9BUZ4 (/IDA) Q9BUZ4 (/IDA) Q9BUZ4 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q9BUZ4 (/TAS) Q9BUZ4 (/TAS) Q9BUZ4 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q61382 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q61382 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q61382 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q61382 (/ISS)
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