CATH Superfamily 2.60.210.10
Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
".
FunFam 2: E3 ubiquitin-protein ligase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 25 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
40 |
O43255 (/IPI)
O43255 (/IPI)
O43255 (/IPI)
O43255 (/IPI)
O43255 (/IPI)
O43255 (/IPI)
O43255 (/IPI)
O43255 (/IPI)
O43255 (/IPI)
O43255 (/IPI)
(30 more) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
36 |
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
(26 more) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
26 |
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
(16 more) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
18 |
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
(8 more) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
17 |
Q06985 (/ISS)
Q7ZVG6 (/ISS)
Q7ZVG6 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
(7 more) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
14 |
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
(4 more) |
|
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
14 |
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
(4 more) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
14 |
P61092 (/IDA)
P61092 (/IDA)
P61092 (/IDA)
P61092 (/IDA)
Q8IUQ4 (/IDA)
Q8IUQ4 (/IDA)
Q8IUQ4 (/IDA)
Q8IUQ4 (/IDA)
Q8IUQ4 (/IDA)
Q8IUQ4 (/IDA)
(4 more) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
14 |
P21461 (/IPI)
P21461 (/IPI)
P21461 (/IPI)
P21461 (/IPI)
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
Q8IUQ4 (/IPI)
(4 more) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
10 | P61092 (/IDA) P61092 (/IDA) P61092 (/IDA) P61092 (/IDA) Q06986 (/IDA) Q06986 (/IDA) Q920M9 (/IDA) Q920M9 (/IDA) Q920M9 (/IDA) Q920M9 (/IDA) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
10 | Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
10 | Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
5 | P61092 (/TAS) P61092 (/TAS) P61092 (/TAS) P61092 (/TAS) Q06985 (/TAS) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
4 | P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) |
|
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
4 | P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
4 | P21461 (/ISM) P21461 (/ISM) P21461 (/ISM) P21461 (/ISM) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
4 | P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
4 | P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
4 | P61092 (/IPI) P61092 (/IPI) P61092 (/IPI) P61092 (/IPI) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
4 | P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) |
|
Disordered domain specific binding GO:0097718
Interacting selectively and non-covalently with a disordered domain of a protein.
|
4 | P61092 (/IPI) P61092 (/IPI) P61092 (/IPI) P61092 (/IPI) |
|
Ubiquitin conjugating enzyme binding GO:0031624
Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins.
|
2 | Q06986 (/ISO) Q06986 (/ISO) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
2 | Q06986 (/IMP) Q06986 (/IMP) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | Q8R4T2 (/NAS) |
|
Ubiquitin conjugating enzyme binding GO:0031624
Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins.
|
1 | Q8R4T2 (/IDA) |
There are 62 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
41 |
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
O43255 (/ISS)
(31 more) |
|
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
24 |
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
(14 more) |
|
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
|
24 |
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
(14 more) |
|
Negative regulation of netrin-activated signaling pathway GO:1902842
Any process that stops, prevents or reduces the frequency, rate or extent of netrin-activated signaling pathway.
|
24 |
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
(14 more) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
20 |
P61092 (/IDA)
P61092 (/IDA)
P61092 (/IDA)
P61092 (/IDA)
Q06986 (/IDA)
Q06986 (/IDA)
Q8IUQ4 (/IDA)
Q8IUQ4 (/IDA)
Q8IUQ4 (/IDA)
Q8IUQ4 (/IDA)
(10 more) |
|
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
17 |
Q06985 (/ISS)
Q7ZVG6 (/ISS)
Q7ZVG6 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
(7 more) |
|
Neuron apoptotic process GO:0051402
Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
|
17 |
P61092 (/ISS)
P61092 (/ISS)
P61092 (/ISS)
P61092 (/ISS)
Q06985 (/ISS)
Q7ZVG6 (/ISS)
Q7ZVG6 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
Q8IUQ4 (/ISS)
(7 more) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
16 |
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
(6 more) |
|
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
16 |
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
(6 more) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
14 |
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
(4 more) |
|
Small GTPase mediated signal transduction GO:0007264
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
|
14 |
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
(4 more) |
|
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
|
14 |
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
(4 more) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
14 |
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
(4 more) |
|
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
|
14 |
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
(4 more) |
|
Cellular protein catabolic process GO:0044257
The chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
|
14 |
O43255 (/IGI)
O43255 (/IGI)
O43255 (/IGI)
O43255 (/IGI)
O43255 (/IGI)
O43255 (/IGI)
O43255 (/IGI)
O43255 (/IGI)
O43255 (/IGI)
O43255 (/IGI)
(4 more) |
|
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
14 |
O43255 (/IGI)
O43255 (/IGI)
O43255 (/IGI)
O43255 (/IGI)
O43255 (/IGI)
O43255 (/IGI)
O43255 (/IGI)
O43255 (/IGI)
O43255 (/IGI)
O43255 (/IGI)
(4 more) |
|
Negative regulation of extrinsic apoptotic signaling pathway GO:2001237
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.
|
14 |
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
O43255 (/IMP)
(4 more) |
|
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
|
10 | Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) |
|
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
|
10 | Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) |
|
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
10 | Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) |
|
Anatomical structure morphogenesis GO:0009653
The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
|
10 | Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) Q8IUQ4 (/TAS) |
|
Protein catabolic process GO:0030163
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
|
10 | Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
10 | Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) |
|
Positive regulation of intrinsic apoptotic signaling pathway GO:2001244
Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway.
|
10 | Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) Q8IUQ4 (/IMP) |
|
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
8 | P21461 (/IDA) P21461 (/IDA) P21461 (/IDA) P21461 (/IDA) P61092 (/IDA) P61092 (/IDA) P61092 (/IDA) P61092 (/IDA) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
6 | P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) Q06986 (/ISO) Q06986 (/ISO) |
|
Sensory organ development GO:0007423
The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.
|
6 | P29304 (/ISS) P61093 (/ISS) P61093 (/ISS) P61093 (/ISS) P61093 (/ISS) Q8I147 (/ISS) |
|
Regulation of R7 cell differentiation GO:0045676
Any process that modulates the frequency, rate or extent of R7 differentiation.
|
6 | P29304 (/ISS) P61093 (/ISS) P61093 (/ISS) P61093 (/ISS) P61093 (/ISS) Q8I147 (/ISS) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
4 | P21461 (/IPI) P21461 (/IPI) P21461 (/IPI) P21461 (/IPI) |
|
Male meiosis I GO:0007141
A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline.
|
4 | P61092 (/IMP) P61092 (/IMP) P61092 (/IMP) P61092 (/IMP) |
|
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
4 | P61092 (/IMP) P61092 (/IMP) P61092 (/IMP) P61092 (/IMP) |
|
Sensory organ development GO:0007423
The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.
|
4 | P21461 (/IMP) P21461 (/IMP) P21461 (/IMP) P21461 (/IMP) |
|
R7 cell fate commitment GO:0007465
The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium.
|
4 | P21461 (/IGI) P21461 (/IGI) P21461 (/IGI) P21461 (/IGI) |
|
R7 cell fate commitment GO:0007465
The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium.
|
4 | P21461 (/IMP) P21461 (/IMP) P21461 (/IMP) P21461 (/IMP) |
|
Post-embryonic development GO:0009791
The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.
|
4 | P61092 (/IMP) P61092 (/IMP) P61092 (/IMP) P61092 (/IMP) |
|
Proteasomal protein catabolic process GO:0010498
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
|
4 | P21461 (/IDA) P21461 (/IDA) P21461 (/IDA) P21461 (/IDA) |
|
Protein catabolic process GO:0030163
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
|
4 | P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) |
|
Protein destabilization GO:0031648
Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
|
4 | Q920M9 (/IMP) Q920M9 (/IMP) Q920M9 (/IMP) Q920M9 (/IMP) |
|
Protein destabilization GO:0031648
Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
|
4 | P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) |
|
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
4 | P21461 (/IMP) P21461 (/IMP) P21461 (/IMP) P21461 (/IMP) |
|
Enteroendocrine cell differentiation GO:0035883
The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system.
|
4 | P21461 (/IMP) P21461 (/IMP) P21461 (/IMP) P21461 (/IMP) |
|
Regulation of multicellular organism growth GO:0040014
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
|
4 | P61092 (/IMP) P61092 (/IMP) P61092 (/IMP) P61092 (/IMP) |
|
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
4 | Q7SYL3 (/ISS) Q8R4T2 (/ISS) Q9I8X5 (/ISS) Q9I8X5 (/ISS) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
4 | P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) |
|
Sevenless signaling pathway GO:0045500
A series of molecular signals initiated by the binding of an extracellular ligand to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
4 | P21461 (/IGI) P21461 (/IGI) P21461 (/IGI) P21461 (/IGI) |
|
Regulation of R7 cell differentiation GO:0045676
Any process that modulates the frequency, rate or extent of R7 differentiation.
|
4 | P21461 (/IMP) P21461 (/IMP) P21461 (/IMP) P21461 (/IMP) |
|
Neuron apoptotic process GO:0051402
Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
|
4 | Q920M9 (/IMP) Q920M9 (/IMP) Q920M9 (/IMP) Q920M9 (/IMP) |
|
Neuron apoptotic process GO:0051402
Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
|
4 | P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) |
|
Positive regulation of intrinsic apoptotic signaling pathway GO:2001244
Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway.
|
4 | P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) |
|
Regulation of protein ubiquitination GO:0031396
Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein.
|
2 | Q06986 (/ISO) Q06986 (/ISO) |
|
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
2 | Q06986 (/ISO) Q06986 (/ISO) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
2 | Q06986 (/ISO) Q06986 (/ISO) |
|
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
|
2 | Q06986 (/ISO) Q06986 (/ISO) |
|
Cellular protein catabolic process GO:0044257
The chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
|
2 | Q06986 (/ISO) Q06986 (/ISO) |
|
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
2 | Q06986 (/ISO) Q06986 (/ISO) |
|
Negative regulation of extrinsic apoptotic signaling pathway GO:2001237
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.
|
2 | Q06986 (/ISO) Q06986 (/ISO) |
|
Mitotic cell cycle checkpoint GO:0007093
A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.
|
1 | Q7SYL3 (/NAS) |
|
Regulation of protein ubiquitination GO:0031396
Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein.
|
1 | Q8R4T2 (/IDA) |
|
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
|
1 | Q8IW03 (/IMP) |
|
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
|
1 | B2RWG3 (/ISO) |
|
Negative regulation of protein targeting to mitochondrion GO:1903215
Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to mitochondrion.
|
1 | Q8IW03 (/IDA) |
|
Negative regulation of protein targeting to mitochondrion GO:1903215
Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to mitochondrion.
|
1 | B2RWG3 (/ISO) |
There are 27 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
24 |
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
(14 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
24 |
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
O43255 (/TAS)
(14 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
23 |
P29304 (/ISS)
P61092 (/ISS)
P61092 (/ISS)
P61092 (/ISS)
P61092 (/ISS)
P61093 (/ISS)
P61093 (/ISS)
P61093 (/ISS)
P61093 (/ISS)
Q06985 (/ISS)
(13 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
23 |
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
(13 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
14 |
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
(4 more) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
14 |
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
O43255 (/IDA)
(4 more) |
|
Beta-catenin destruction complex GO:0030877
A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
|
10 | Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) Q8IUQ4 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
8 | P21461 (/IDA) P21461 (/IDA) P21461 (/IDA) P21461 (/IDA) Q920M9 (/IDA) Q920M9 (/IDA) Q920M9 (/IDA) Q920M9 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
7 | P61092 (/ISS) P61092 (/ISS) P61092 (/ISS) P61092 (/ISS) Q06985 (/ISS) Q7ZVG6 (/ISS) Q7ZVG6 (/ISS) |
|
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
|
6 | P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) Q06986 (/ISO) Q06986 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
6 | P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) Q06986 (/ISO) Q06986 (/ISO) |
|
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
|
5 | Q8R4T2 (/IDA) Q920M9 (/IDA) Q920M9 (/IDA) Q920M9 (/IDA) Q920M9 (/IDA) |
|
Ubiquitin ligase complex GO:0000151
A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
|
4 | P21461 (/IDA) P21461 (/IDA) P21461 (/IDA) P21461 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | Q920M9 (/IDA) Q920M9 (/IDA) Q920M9 (/IDA) Q920M9 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) |
|
SCF ubiquitin ligase complex GO:0019005
A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
|
4 | P61092 (/IMP) P61092 (/IMP) P61092 (/IMP) P61092 (/IMP) |
|
Beta-catenin destruction complex GO:0030877
A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
|
4 | P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) P61092 (/ISO) |
|
Beta-catenin destruction complex GO:0030877
A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
|
4 | Q920M9 (/ISS) Q920M9 (/ISS) Q920M9 (/ISS) Q920M9 (/ISS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q06986 (/ISO) Q06986 (/ISO) |
|
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
2 | Q06986 (/ISO) Q06986 (/ISO) |
|
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
2 | Q06986 (/ISO) Q06986 (/ISO) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
2 | Q06986 (/ISO) Q06986 (/ISO) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q8IW03 (/IDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | B2RWG3 (/ISO) |
|
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
1 | Q8R4T2 (/IDA) |
|
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
1 | Q8R4T2 (/IDA) |
