The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 19: TNF-receptor-associated factor 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
3 Q9UAC4 (/ISS) Q9W3I9 (/ISS) Q9XYQ9 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q9UAC4 (/IPI) Q9W3I9 (/IPI) Q9XYQ9 (/IPI)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 Q9UAC4 (/ISM) Q9W3I9 (/ISM) Q9XYQ9 (/ISM)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
3 Q9UAC4 (/ISS) Q9W3I9 (/ISS) Q9XYQ9 (/ISS)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
3 Q9UAC4 (/TAS) Q9W3I9 (/TAS) Q9XYQ9 (/TAS)
Cell death GO:0008219
Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
3 Q9UAC4 (/IGI) Q9W3I9 (/IGI) Q9XYQ9 (/IGI)
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
3 Q9UAC4 (/IMP) Q9W3I9 (/IMP) Q9XYQ9 (/IMP)
Stress-activated protein kinase signaling cascade GO:0031098
A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals.
3 Q9UAC4 (/IMP) Q9W3I9 (/IMP) Q9XYQ9 (/IMP)
Regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122
Any process that modulates I-kappaB kinase/NF-kappaB signaling.
3 Q9UAC4 (/IMP) Q9W3I9 (/IMP) Q9XYQ9 (/IMP)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
3 Q9UAC4 (/IMP) Q9W3I9 (/IMP) Q9XYQ9 (/IMP)
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
3 Q9UAC4 (/IGI) Q9W3I9 (/IGI) Q9XYQ9 (/IGI)
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
3 Q9UAC4 (/IPI) Q9W3I9 (/IPI) Q9XYQ9 (/IPI)
Regulation of defense response to virus GO:0050688
Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism.
3 Q9UAC4 (/IMP) Q9W3I9 (/IMP) Q9XYQ9 (/IMP)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q9UAC4 (/ISS) Q9W3I9 (/ISS) Q9XYQ9 (/ISS)
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