Any series of molecular signals generated as a consequence of a cytoplasmic pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.

Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.

The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues.

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.