The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 4: Bone morphogenetic protein 5 preproprotein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
BMP receptor binding GO:0070700
Interacting selectively and non-covalently with a BMP receptor.
10 P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P49003 (/IPI) P49003 (/IPI)
BMP receptor binding GO:0070700
Interacting selectively and non-covalently with a BMP receptor.
2 P49003 (/ISO) P49003 (/ISO)

There are 54 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
10 P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS)
Endocardial cushion formation GO:0003272
The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
10 P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS)
Type B pancreatic cell development GO:0003323
The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
10 P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA)
Pericardium morphogenesis GO:0003344
The process in which the anatomical structure of the pericardium is generated and organized.
10 P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
10 P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
10 P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA)
Negative regulation of epithelial to mesenchymal transition GO:0010719
Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
10 P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS)
Positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862
Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
10 P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA)
Negative regulation of steroid biosynthetic process GO:0010894
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
10 P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA)
Neural fold elevation formation GO:0021502
The process in which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm.
10 P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS)
Hindbrain development GO:0030902
The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).
10 P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS)
Negative regulation of aldosterone biosynthetic process GO:0032348
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone.
10 P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA)
Negative regulation of insulin-like growth factor receptor signaling pathway GO:0043569
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling.
10 P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
10 P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA)
Cardiac muscle tissue development GO:0048738
The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.
10 P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS)
Positive regulation of epithelial cell proliferation GO:0050679
Any process that activates or increases the rate or extent of epithelial cell proliferation.
10 P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA)
Pharyngeal system development GO:0060037
The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear.
10 P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS)
Cardiac septum morphogenesis GO:0060411
The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart.
10 P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS)
Chorio-allantoic fusion GO:0060710
The cell-cell adhesion process in which the cells of the chorion fuse to the cells of the allantois.
10 P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS)
Heart trabecula morphogenesis GO:0061384
The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.
10 P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS)
Negative regulation of mononuclear cell migration GO:0071676
Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.
10 P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS)
Positive regulation of dendrite development GO:1900006
Any process that activates or increases the frequency, rate or extent of dendrite development.
10 P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA)
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
10 P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS) P22003 (/NAS)
Allantois development GO:1905069
The process whose specific outcome is the progression of an allantois over time, from its formation to the mature structure.
10 P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS)
Negative regulation of cortisol biosynthetic process GO:2000065
Any process that stops, prevents, or reduces the frequency, rate or extent of cortisol biosynthetic process.
10 P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA) P22003 (/IDA)
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
2 P49003 (/IMP) P49003 (/IMP)
Endocardial cushion formation GO:0003272
The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
2 P49003 (/IGI) P49003 (/IGI)
Type B pancreatic cell development GO:0003323
The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
2 P49003 (/ISO) P49003 (/ISO)
Pericardium morphogenesis GO:0003344
The process in which the anatomical structure of the pericardium is generated and organized.
2 P49003 (/IGI) P49003 (/IGI)
Pattern specification process GO:0007389
Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.
2 P49003 (/IMP) P49003 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 P49003 (/ISO) P49003 (/ISO)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
2 P49003 (/ISO) P49003 (/ISO)
Positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862
Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
2 A0A0R4ILD5 (/IMP) Q7T288 (/IMP)
Positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862
Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
2 P49003 (/ISO) P49003 (/ISO)
Negative regulation of steroid biosynthetic process GO:0010894
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
2 P49003 (/ISO) P49003 (/ISO)
Neural crest cell development GO:0014032
The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
2 A0A0R4ILD5 (/IMP) Q7T288 (/IMP)
Neural fold elevation formation GO:0021502
The process in which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm.
2 P49003 (/IGI) P49003 (/IGI)
Male genitalia development GO:0030539
The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure.
2 P49003 (/IGI) P49003 (/IGI)
Hindbrain development GO:0030902
The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).
2 P49003 (/IGI) P49003 (/IGI)
Negative regulation of aldosterone biosynthetic process GO:0032348
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone.
2 P49003 (/ISO) P49003 (/ISO)
Negative regulation of insulin-like growth factor receptor signaling pathway GO:0043569
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling.
2 P49003 (/ISO) P49003 (/ISO)
Ear development GO:0043583
The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.
2 P49003 (/IMP) P49003 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P49003 (/ISO) P49003 (/ISO)
Cardiac muscle tissue development GO:0048738
The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.
2 P49003 (/IGI) P49003 (/IGI)
Positive regulation of epithelial cell proliferation GO:0050679
Any process that activates or increases the rate or extent of epithelial cell proliferation.
2 P49003 (/ISO) P49003 (/ISO)
Pharyngeal system development GO:0060037
The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear.
2 P49003 (/IGI) P49003 (/IGI)
Cardiac septum morphogenesis GO:0060411
The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart.
2 P49003 (/IGI) P49003 (/IGI)
Chorio-allantoic fusion GO:0060710
The cell-cell adhesion process in which the cells of the chorion fuse to the cells of the allantois.
2 P49003 (/IGI) P49003 (/IGI)
Heart trabecula morphogenesis GO:0061384
The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.
2 P49003 (/IGI) P49003 (/IGI)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 A0A0R4ILD5 (/IMP) Q7T288 (/IMP)
Anterior head development GO:0097065
The process whose specific outcome is the progression of the anterior part of the head over time, from its formation to the mature structure.
2 P49003 (/IMP) P49003 (/IMP)
Positive regulation of dendrite development GO:1900006
Any process that activates or increases the frequency, rate or extent of dendrite development.
2 P49003 (/ISO) P49003 (/ISO)
Allantois development GO:1905069
The process whose specific outcome is the progression of an allantois over time, from its formation to the mature structure.
2 P49003 (/IGI) P49003 (/IGI)
Negative regulation of cortisol biosynthetic process GO:2000065
Any process that stops, prevents, or reduces the frequency, rate or extent of cortisol biosynthetic process.
2 P49003 (/ISO) P49003 (/ISO)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
10 P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
10 P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS) P22003 (/ISS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P49003 (/ISO) P49003 (/ISO)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
2 P49003 (/ISO) P49003 (/ISO)