The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11: Growth/differentiation factor 5

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P43026 (/IPI) P43027 (/IPI)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 M0RAY4 (/IMP)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 P43027 (/ISO)
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
1 P43026 (/TAS)
BMP binding GO:0036122
Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family.
1 P43026 (/IPI)
BMP binding GO:0036122
Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family.
1 P43027 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P43026 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P43027 (/ISO)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of chondrocyte differentiation GO:0032332
Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation.
2 P43026 (/IDA) P43027 (/IDA)
Transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P43027 (/IGI)
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P43026 (/TAS)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
1 P43026 (/TAS)
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 M0RAY4 (/IEP)
Embryonic limb morphogenesis GO:0030326
The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping.
1 P43027 (/IMP)
Positive regulation of BMP signaling pathway GO:0030513
Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.
1 P43026 (/IDA)
Positive regulation of BMP signaling pathway GO:0030513
Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.
1 P43027 (/ISO)
Negative regulation of chondrocyte differentiation GO:0032331
Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation.
1 P43026 (/IDA)
Negative regulation of chondrocyte differentiation GO:0032331
Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation.
1 P43027 (/ISO)
Positive regulation of chondrocyte differentiation GO:0032332
Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation.
1 P43027 (/IGI)
Positive regulation of chondrocyte differentiation GO:0032332
Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation.
1 P43027 (/ISO)
Forelimb morphogenesis GO:0035136
The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human.
1 P43027 (/IMP)
Hindlimb morphogenesis GO:0035137
The process in which the anatomical structures of the hindlimb are generated and organized.
1 P43027 (/IMP)
Regulation of multicellular organism growth GO:0040014
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
1 P43027 (/IMP)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
1 M0RAY4 (/IDA)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
1 P43027 (/ISO)
Ossification involved in bone remodeling GO:0043932
The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli.
1 M0RAY4 (/IEP)
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
1 M0RAY4 (/IDA)
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
1 P43027 (/ISO)
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
1 P43026 (/IDA)
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
1 P43027 (/ISO)
Regulation of SMAD protein signal transduction GO:0060390
Any process that modulates the rate, frequency or extent of SMAD protein signal transduction. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
1 P43026 (/IDA)
Regulation of SMAD protein signal transduction GO:0060390
Any process that modulates the rate, frequency or extent of SMAD protein signal transduction. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
1 P43027 (/ISO)
SMAD protein signal transduction GO:0060395
The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell.
1 P43026 (/IDA)
SMAD protein signal transduction GO:0060395
The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell.
1 P43027 (/ISO)
Chondroblast differentiation GO:0060591
The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes.
1 P43026 (/IDA)
Chondroblast differentiation GO:0060591
The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes.
1 P43027 (/ISO)
Negative regulation of mesenchymal cell apoptotic process GO:2001054
Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process.
1 P43027 (/IMP)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P43026 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 M0RAY4 (/NAS)