The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: SPRY domain-containing SOCS box protein 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
11 A1Z6E0 (/IPI) A1Z6E0 (/IPI) Q8R5B6 (/IPI) Q8R5B6 (/IPI) Q96A44 (/IPI) Q96A44 (/IPI) Q96A44 (/IPI) Q96BD6 (/IPI) Q96BD6 (/IPI) Q9D5L7 (/IPI)
(1 more)
Protein binding, bridging involved in substrate recognition for ubiquitination GO:1990756
The binding activity of a molecule that brings together a ubiquitin ligase and its substrate. Usually mediated by F-box BTB/POZ domain proteins.
7 Q5E9X6 (/ISS) Q5E9X6 (/ISS) Q5E9X6 (/ISS) Q8R5B6 (/ISS) Q8R5B6 (/ISS) Q9D5L7 (/ISS) Q9D5L7 (/ISS)
Protein binding, bridging involved in substrate recognition for ubiquitination GO:1990756
The binding activity of a molecule that brings together a ubiquitin ligase and its substrate. Usually mediated by F-box BTB/POZ domain proteins.
5 Q96A44 (/IPI) Q96A44 (/IPI) Q96A44 (/IPI) Q96BD6 (/IPI) Q96BD6 (/IPI)
Protein binding, bridging involved in substrate recognition for ubiquitination GO:1990756
The binding activity of a molecule that brings together a ubiquitin ligase and its substrate. Usually mediated by F-box BTB/POZ domain proteins.
4 Q8R5B6 (/ISO) Q8R5B6 (/ISO) Q9D5L7 (/ISO) Q9D5L7 (/ISO)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
7 Q5E9X6 (/ISS) Q5E9X6 (/ISS) Q5E9X6 (/ISS) Q8R5B6 (/ISS) Q8R5B6 (/ISS) Q9D5L7 (/ISS) Q9D5L7 (/ISS)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
7 Q5E9X6 (/ISS) Q5E9X6 (/ISS) Q5E9X6 (/ISS) Q8R5B6 (/ISS) Q8R5B6 (/ISS) Q9D5L7 (/ISS) Q9D5L7 (/ISS)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
5 Q96A44 (/IDA) Q96A44 (/IDA) Q96A44 (/IDA) Q96BD6 (/IDA) Q96BD6 (/IDA)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
5 Q96A44 (/IDA) Q96A44 (/IDA) Q96A44 (/IDA) Q96BD6 (/IDA) Q96BD6 (/IDA)
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
5 Q96A44 (/TAS) Q96A44 (/TAS) Q96A44 (/TAS) Q96BD6 (/TAS) Q96BD6 (/TAS)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
4 Q8R5B6 (/ISO) Q8R5B6 (/ISO) Q9D5L7 (/ISO) Q9D5L7 (/ISO)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
4 Q8R5B6 (/ISO) Q8R5B6 (/ISO) Q9D5L7 (/ISO) Q9D5L7 (/ISO)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
3 Q96A44 (/IMP) Q96A44 (/IMP) Q96A44 (/IMP)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
3 Q96A44 (/IMP) Q96A44 (/IMP) Q96A44 (/IMP)
Positive regulation of protein polyubiquitination GO:1902916
Any process that activates or increases the frequency, rate or extent of protein polyubiquitination.
3 Q96A44 (/IDA) Q96A44 (/IDA) Q96A44 (/IDA)
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
2 Q96BD6 (/TAS) Q96BD6 (/TAS)
Pole cell migration GO:0007280
The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form.
2 A1Z6E0 (/IMP) A1Z6E0 (/IMP)
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
2 A1Z6E0 (/IMP) A1Z6E0 (/IMP)
Oocyte anterior/posterior axis specification GO:0007314
Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster.
2 A1Z6E0 (/IMP) A1Z6E0 (/IMP)
Pole plasm assembly GO:0007315
Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster.
2 A1Z6E0 (/IMP) A1Z6E0 (/IMP)
Wing disc morphogenesis GO:0007472
The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura.
2 A1Z6E0 (/IMP) A1Z6E0 (/IMP)
Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
2 A1Z6E0 (/IMP) A1Z6E0 (/IMP)
Cuticle pattern formation GO:0035017
The regionalization process that gives rise to the patterns of cell differentiation in the cuticle.
2 A1Z6E0 (/IMP) A1Z6E0 (/IMP)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
2 Q8R5B6 (/ISO) Q8R5B6 (/ISO)
Positive regulation of protein catabolic process GO:0045732
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
2 A1Z6E0 (/IMP) A1Z6E0 (/IMP)
Dorsal appendage formation GO:0046843
Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration.
2 A1Z6E0 (/IMP) A1Z6E0 (/IMP)
Positive regulation of protein polyubiquitination GO:1902916
Any process that activates or increases the frequency, rate or extent of protein polyubiquitination.
2 Q8R5B6 (/ISO) Q8R5B6 (/ISO)
Positive regulation of protein polyubiquitination GO:1902916
Any process that activates or increases the frequency, rate or extent of protein polyubiquitination.
2 Q8R5B6 (/ISS) Q8R5B6 (/ISS)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 Q5E9X6 (/ISS) Q5E9X6 (/ISS) Q5E9X6 (/ISS) Q8R5B6 (/ISS) Q8R5B6 (/ISS) Q9D5L7 (/ISS) Q9D5L7 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 Q96A44 (/IDA) Q96A44 (/IDA) Q96A44 (/IDA) Q96BD6 (/IDA) Q96BD6 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 Q96A44 (/TAS) Q96A44 (/TAS) Q96A44 (/TAS) Q96BD6 (/TAS) Q96BD6 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 Q8R5B6 (/ISO) Q8R5B6 (/ISO) Q9D5L7 (/ISO) Q9D5L7 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 A1Z6E0 (/IDA) A1Z6E0 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 A1Z6E0 (/IDA) A1Z6E0 (/IDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
2 A1Z6E0 (/IDA) A1Z6E0 (/IDA)
Cul5-RING ubiquitin ligase complex GO:0031466
A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.
2 A1Z6E0 (/IDA) A1Z6E0 (/IDA)
Pole plasm GO:0045495
Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo.
2 A1Z6E0 (/IDA) A1Z6E0 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 A1Z6E0 (/IDA) A1Z6E0 (/IDA)
Elongin complex GO:0070449
A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (abut 100 kDa)and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa)subunits.
2 A1Z6E0 (/IDA) A1Z6E0 (/IDA)
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